Mutual Action of Anticancer and Antiparasitic Drugs: Are there any Shared Targets?

Dorosti, Zahra; Yousefi, Mohammad Reza; Sharafi, Seyedeh Maryam; Darani, Hossein Yousofi

doi:10.2217/fon.14.65

Cited by 22 publications

(15 citation statements)

References 139 publications

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“…Conceivably, due to the intense replication of this parasite during acute infection, it could be strongly affected by DNA damage or free radicals. Indeed, reports in the literature have indicated that anti-cancer drugs that affect cellular proliferation can be used as anti-microbial agents because both cell types share common behaviors concerning their high proliferative capabilities [27][28][29]. Indeed, a recent work evidenced the antileishmanial actions of other two isobenzofuranone derivatives and indicated that these actions were due to the induction of reactive oxygen species (ROS)-mediated apoptosis-like cell death and the inhibition of topoisomerases [30].…”

Section: Resultsmentioning

confidence: 99%

The Antileishmanial Potential of C-3 Functionalized Isobenzofuranones against Leishmania (Leishmania) Infantum Chagasi

et al. 2015

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Leishmaniases are diseases caused by protozoan parasites of the genus Leishmania. Clinically, leishmaniases range from cutaneous to visceral forms, with estimated global incidences of 1.2 and 0.4 million cases per year, respectively. The treatment of these diseases relies on multiple parenteral injections with pentavalent antimonials or amphotericin B. However, these pharmaceuticals are either too toxic or expensive for routine use in developing countries. These facts call for safer, cheaper, and more effective new antileishmanial drugs. In this investigation, we describe the results of the assessment of the activities of a series of isobenzofuran-1(3H)-ones (phtalides) against Leishmania (Leishmania) infantum chagasi, which is the main causative agent of visceral leishmaniasis in the New World. The compounds were tested at concentrations of 100, 75, 50, 25 and 6.25 µM over 24, 48, and 72 h. After 48 h of treatment at the 100 µM concentration, compounds 7 and 8 decreased parasite viability to 4% and 6%, respectively. The concentration that gives half-maximal responses (LC 50 ) for the antileishmanial activities of compounds 7 and 8 against promastigotes after 24 h were 60.48 and 65.93 µM, respectively. Additionally, compounds 7 and 8 significantly reduced parasite infection in macrophages.

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Section: Resultsmentioning

confidence: 99%

The Antileishmanial Potential of C-3 Functionalized Isobenzofuranones against Leishmania (Leishmania) Infantum Chagasi

et al. 2015

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“…The three basic building blocks of the biosynthesis of 3-alkylpiperidine alkaloids manzamine C (1 52 ), keramaphidin C ( 165 A), and keramamine C ( 153 ) include ammonia, a propenal and a variable chain of saturated or unsaturated linear dialdehyde [ 75 , 127 , 128 ].…”

Section: Biosynthetic Considerationsmentioning

confidence: 99%

Marine-Derived Macrocyclic Alkaloids (MDMAs): Chemical and Biological Diversity

et al. 2020

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The curiosity and attention that researchers have devoted to alkaloids are due to their bioactivities, structural diversity, and intriguing chemistry. Marine-derived macrocyclic alkaloids (MDMAs) are considered to be a potential source of drugs. Trabectedin, a tetrahydroisoquinoline derivative, has been approved for the treatment of metastatic soft tissue sarcoma and ovarian cancers. MDMAs displayed potent activities that enabled them to be used as anticancer, anti-invasion, antimalarial, antiplasmodial, and antimicrobial. This review presents the reported chemical structures, biological activities, and structure–activity relationships of macrocyclic alkaloids from marine organisms that have been published since their discovery until May 2020. This includes 204 compounds that are categorized under eight subclasses: pyrroles, quinolines, bis-quinolizidines, bis-1-oxaquinolizidines, 3-alkylpiperidines, manzamines, 3-alkyl pyridinium salts, and motuporamines.

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“…However, parasites and cancer cells have some common features like their capacity for rapid cell division, some immune evasion and defense strategies, high rate of aerobic glycolysis with key glycolytic enzymes, need of nucleic acid biosynthesis, etc. These similarities noy only support DNA as a valid target for antiparasitic metal-based drugs but also the selection of metal centres that have proved to be useful in cancer therapy, like platinum or palladium (see below) (Williamson and Scott-Finnigan, 1975;Kinnamon et al, 1979;Fuertes et al, 2008;Dorosti et al, 2014;Sullivan et al, 2015).…”

Section: Strategies For the Rational Design Of Antiparasitic Metal Complexesmentioning

confidence: 99%

Facing Diseases Caused by Trypanosomatid Parasites: Rational Design of Pd and Pt Complexes With Bioactive Ligands

Gambino

Otero

2022

Front. Chem.

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Human African Trypanosomiasis (HAT), Chagas disease or American Trypanosomiasis (CD), and leishmaniases are protozoan infections produced by trypanosomatid parasites belonging to the kinetoplastid order and they constitute an urgent global health problem. In fact, there is an urgent need of more efficient and less toxic chemotherapy for these diseases. Medicinal inorganic chemistry currently offers an attractive option for the rational design of new drugs and, in particular, antiparasitic ones. In this sense, one of the main strategies for the design of metal-based antiparasitic compounds has been the coordination of an organic ligand with known or potential biological activity, to a metal centre or an organometallic core. Classical metal coordination complexes or organometallic compounds could be designed as multifunctional agents joining, in a single molecule, different chemical species that could affect different parasitic targets. This review is focused on the rational design of palladium(II) and platinum(II) compounds with bioactive ligands as prospective drugs against trypanosomatid parasites that has been conducted by our group during the last 20 years.

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Mutual Action of Anticancer and Antiparasitic Drugs: Are there any Shared Targets?

Cited by 22 publications

References 139 publications

The Antileishmanial Potential of C-3 Functionalized Isobenzofuranones against Leishmania (Leishmania) Infantum Chagasi

The Antileishmanial Potential of C-3 Functionalized Isobenzofuranones against Leishmania (Leishmania) Infantum Chagasi

Marine-Derived Macrocyclic Alkaloids (MDMAs): Chemical and Biological Diversity

Facing Diseases Caused by Trypanosomatid Parasites: Rational Design of Pd and Pt Complexes With Bioactive Ligands

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