Mutator genes—pacemakers of evolution

Thompson, James N.; Woodruff, Robert W.

doi:10.1038/274317a0

Cited by 87 publications

(38 citation statements)

References 55 publications

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“…In addition, beginning with Sturtevant (1937) others have suggested that genes which increase mutation rates in natural populations of sexual organisms will be selected against and any interference with the operation of this selection will increase the mutation rate (see discussions of this topic in Dobzhansky, 1951;Dubinin, 1964;Williams, 1966;Kimura, 1967;Leigh, 1970Leigh, , 1973Karlin and McGregor, 1974;Thompson and Woodruff, 1978;Gillespie, 1981a, l981b;Woodruff eta!., 1983). For example, hybridisation among migrants in the large-density winery population might be expected to increase mutation rates by the documented intraspecific hybrid release of mutator activity (Thompson and Woodruff, 1980;Woodruff et a!., 1980;Shaw et a!., 1983).…”

Section: Discussionmentioning

confidence: 99%

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Variation in spontaneous mutation and repair in natural population lines of Drosophila melanogaster

et al. 1984

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SUMMARYTo measure the possible correlation between genetic damage and repair ability in natural populations of a eukaryote, we compared the spontaneous frequency of sex-linked recessive lethal mutations and male recombination, which is associated with DNA transposable element induced chromosome breakage, with DNA repair efficiency in isofemale lines of a winery population of Drosophila melanogaster from Australia. Repair efficiency was measured by maternal effects on ring-X chromosome loss. Significant amounts of genetic variability for spontaneous rates of genetic change and for repair ability were observed in the isofemale lines collected during periods of low and high population density. However, there were no correlations between repair ability and rates of genetic damage. Possible reasons for the absence of correlation are discussed, along with the observations that: (a) the frequency of lethal mutations and ring-X chromosome losses were significantly higher in the small, resident population; (b) the rates of ring chromosome losses and especially lethal mutations are uniform over periods of time; (c) and inbreeding of isofemale lines leads to a reduction of the high spontaneous mutation rates.

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Section: Discussionmentioning

confidence: 99%

“…Hybrid dysgenic mutator activity was quantified by measuring the rate of male recombination (Thompson and Woodruff, 1978). Male recombination is positively correlated with the rate of chromosome breakage and the induction of mutations attributable to movement of transposing genetic sequences (reviewed in Woodruff et aL, 1983).…”

Section: Methodsmentioning

confidence: 99%

Variation in spontaneous mutation and repair in natural population lines of Drosophila melanogaster

et al. 1984

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“…Two common explanations of this socalled rare allele phenomenon have been that either hybridisation causes increased mutation rates due to the disruption of genetic suppressor systems and the release of mutator activity Table 4 Matrix correlation coefficients (Mantel test) for pairs of allele frequency difference matrices, based on pooled data. These coefficients are for descriptive purposes only because only alleles which displayed significant spatial pattern were tested against one another ( Thompson and Woodruff, 1978), or that intragenic recombination in hybrid zones produces unique alleles (Watt, 1972;Golding and Strobeck, 1983). Although contact between individuals with divergent genomes is implicit in these explanations, an increase in the frequency of rare or unique alleles imparts little information on the history of a contact zone (primary vs secondary intergradation).…”

Section: Discussionmentioning

confidence: 99%

The genetics of differentiation in a stream population of the threespine stickleback, Gasterosteus aculeatus

Baumgartner

1986

Heredity

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Clinal variation occurs at three polymorphic enzyme loci in a population of the threespine stickleback, Gasterosteus aculeatus, from the Brush Creek drainage, a small coastal system in northern California, U.S.A. The drainage consists of two tributary streams, representing two broad ecological units based on stream gradient, which meet at a coastal lagoon. Seven localities were sampled once each year for three years, and the allele frequencies for alcohol dehydrogenase (Adh), glucophosphate isomerase (Gpi-2), and phosphoglucomutase (Pgm) were estimated for each sample by gel electrophoresis. At each locus, all samples were in Hardy-Weinberg equilibrium, and there was no evidence for temporal heterogeneity. There was significant spatial heterogeneity detected for all three loci, which was particularly strong for Pgm. Although the degree of differentiation in allozyme frequencies differed among the three loci, the overall patterns of differentiation were very similar for all three. The similarity of spatial patterns of differentiation is explained by population processes, such as natural selection and gene flow; linkage disequilibrium among the loci was not detected. The allelic diversity within the drainage was very high, and the distribution of alleles among localities suggested that the rate of gene flow within the drainage was relatively high. These data suggest that the allozyme dines, as well as a parallel dine for the ratio of lateral plate morphs, are maintained in their current ecotonal position by gene flow across the ecotone with differential selection on either side. However, the history of the drainage suggests that the dines originated when isolated stickleback populations inhabiting ecologically distinct habitats within the drainage came into secondary contact.

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“…Finally, the Oklahoma lines carry mutator factors of the hybrid dysgenesis sytem (Thompson and Woodruff, 1978;Woodruff and Thompson, 1980). Woodruff and Thompson (1977) tested lines 1 to 25 and found all to induce male recombination in the progeny of outcrosses to the sensitive Total 1641 93 399 dp b cn bw tester strain.…”

Section: Discussior'mentioning

confidence: 99%

Polygene polymorphism affecting wing vein formation in a natural population of Drosophila melanogaster

Thoday

Thompson

1984

Heredity

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SUMMARYOne hundred isofemale lines originating from the same (Oklahoma) wild population of Drosophila melanogaster were assayed for cryptic variation capable of producing gaps in wing vein L5 in flies heterozygous for genomes from an enhanced veinlet line.There were very significant differences between isofemale lines, and the Oklahoma population was clearly polymorphic for vein-gap genes of subthreshold expression. Many of the isofemale lines were also segregating for such genes.There were no obvious relationships between this polymorphism and others that have been studied in the Oklahoma lines.

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Mutator genes—pacemakers of evolution

Cited by 87 publications

References 55 publications

Variation in spontaneous mutation and repair in natural population lines of Drosophila melanogaster

Variation in spontaneous mutation and repair in natural population lines of Drosophila melanogaster

The genetics of differentiation in a stream population of the threespine stickleback, Gasterosteus aculeatus

Polygene polymorphism affecting wing vein formation in a natural population of Drosophila melanogaster

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