Mutations in yeast are deleterious on average regardless of the degree of adaptation to the testing environment
Kevin Bao,
Brant R. Strayer,
Neil P. Braker
et al.
Abstract:The role of spontaneous mutations in evolution depends on the distribution of their effects on fitness. Despite a general consensus that new mutations are deleterious on average, a handful of mutation accumulation experiments in diverse organisms instead suggest that beneficial and deleterious mutations can have comparable fitness impacts, i.e. the product of their respective rates and effects can be roughly equal. We currently lack a general framework for predicting when such a pattern will occur. One idea is… Show more
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