“…Genetic defects of Carney complex are mapped to chromosomal region 2p16 (Stratakis et al ., 1996) and 17q22–24 (Casey et al ., 1998). The PRKAR1A gene encoding the R1α regulatory subunit of cAMP‐dependent protein kinase A (PKA) was mapped to 17q22–24, and several mutations of the gene were detected in some kindreds of individuals with Carney complex (Casey et al ., 2000; Kirschner et al ., 2000a). Based on these results, we hypothesized that PRKAR1A could function as a tumour suppressor gene in some sporadic GH‐secreting adenomas.…”