Mutations in <i>TP53</i> and <i>CTNNB1</i> in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand

Galy, Olivier; Chemin, Isabelle; Roux, Emilie Le; Villar, Stéphanie; Calvez-Kelm, Florence Le; Lereau, Myriam; Gouas, Doriane; Vieco, Beatriz; Suarez, Iris; Navas, María Cristina; Chevallier, M.; Nordér, Helené; Srivatanakul, Petcharin; Karalak, Anant; Sangrajrang, Suleeporn; Trépo, Christian; Hainaut, Pierre

doi:10.1155/2011/697162

Cited by 15 publications

(16 citation statements)

References 42 publications

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“…It was quite similar to a study of Northeast Peninsular Malaysia in which HBV was recorded in 57.6% but less HCV, 2.4%, of HCC study (Norsa'adah et al, 2013) and in some parts of Thailand where HBV was identified between 40-65% of HCC cases, and HCV was recognized in 16-17% of cases (Samboon et al, 2014;Galy et al, 2011;Tangkijvanich et al, 2003). In Vietnam, a study found that HBV was detected in 60.5% of HCC cases and HCV was discovered in 2.6% of the cases (Ding et al, 2003).…”

Section: Discussionsupporting

confidence: 86%

Characteristics of Liver Cancer at Khmer-Soviet Friendship Hospital in Phnom Penh, Cambodia

Narin

Hamajima²,

Kouy³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 86%

Characteristics of Liver Cancer at Khmer-Soviet Friendship Hospital in Phnom Penh, Cambodia

Narin

Hamajima²,

Kouy³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…A recent estimate of the risk of HCC attributable to aflatoxin for Thailand has provided figures of 0.53–0.73 and 15.9–21.9/10 5 person years, in HBsAg-negative and positive subjects, respectively [11]. In a recent study on a small group of surgically resected HCC patients at the National Cancer Institute, Bangkok, we reported R249S mutation in 7/26 (27%) cases, suggesting that the contribution of AFB 1 to the burden of HCC in Thailand is far from negligible [15]. However, an earlier epidemiological study in Thailand using a albumin-adduct biomarker to assess aflatoxin exposure, failed to identify an aflatoxin-associated risk for HCC [16].…”

Section: Introductionmentioning

confidence: 83%

Aflatoxin-Induced TP53 R249S Mutation in HepatoCellular Carcinoma in Thailand: Association with Tumors Developing in the Absence of Liver Cirrhosis

et al. 2012

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Primary Liver Cancer (PLC) is the leading cause of death by cancer among males in Thailand and the 3rd among females. Most cases are hepatocellular carcinoma (HCC) but cholangiocarcinomas represent between 4 and 80% of liver cancers depending upon geographic area. Most HCC are associated with chronic infection by Hepatitis B Virus while a G→T mutation at codon 249 of the TP53 gene, R249S, specific for exposure to aflatoxin, is detected in tumors for up to 30% of cases. We have used Short Oligonucleotide Mass Analysis (SOMA) to quantify free circulating R249S-mutated DNA in plasma using blood specimens collected in a hospital case:control study. Plasma R249S-mutated DNA was detectable at low concentrations (≥67 copies/mL) in 53 to 64% of patients with primary liver cancer or chronic liver disease and in 19% of controls. 44% of patients with HCC and no evidence of cirrhosis had plasma concentrations of R249S-mutated DNA ≥150 copies/mL, compared to 21% in patients with both HCC and cirrhosis, 22% in patients with cholangiocarcinoma, 12% in patients with non-cancer chronic liver disease and 3% of subjects in the reference group. Thus, plasma concentrations of R249S-mutated DNA ≥150 copies/mL tended to be more common in patients with HCC developing without pre-existing cirrhosis (p = 0.027). Overall, these results support the preferential occurrence of R249S-mutated DNA in HCC developing in the absence of cirrhosis in a context of HBV chronic infection.

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“…38 A recent study of a small group of surgically resected HCC patients at the National Cancer Institute, Bangkok reported a R249S mutation in 7/26 (27%) cases, suggesting that the contribution of AFB1 to the burden of HCC in Thailand is far from negligible. 39 In contrast, an earlier epidemiological study in Thailand using a albuminadduct biomarker to assess aflatoxin exposure failed to identify an aflatoxin associated risk for HCC. 40 …”

Section: Role Of Aflatoxin Afb1mentioning

confidence: 94%

Risk Factors for the Development of Hepatocellular Carcinoma in Thailand

Chitapanarux¹,

Phornphutkul²

2015

JCTH

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Hepatocellular carcinoma (HCC) is the most common type of liver cancer worldwide. The incidence of HCC is on the rise in Thailand, where it has become the most common malignancy in males and the third most common in females. Here, we review some of the risk factors that have contributed to this increase in HCC incidence in the Thai population. Hepatitis B virus (HBV) is the main etiologic risk factor for HCC, followed by hepatitis C virus (HCV). Patients with HBV genotype C have a higher positive rate of hepatitis B early antigen (HBeAg) and progress to cirrhosis and HCC earlier than genotype B. For HCV patients, 16% developed HCC associated cirrhosis by year 5 after diagnosis, and the cumulative risk for death from HCC at year 10 was 60%. Dietary exposure to the fungal hepatocarcinogen aflatoxin B1 has been shown to interact synergistically with HBV infection to increase the risk of early onset HCC. Chronic alcohol abuse remains an important risk factor for malignant transformation of hepatocytes, frequently in association with alcohol-induced cirrhosis. In recent years, obesity and metabolic syndrome have markedly increased the incidence of HCC and are important causes of HCC in some resource-rich regions.

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Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand

Cited by 15 publications

References 42 publications

Characteristics of Liver Cancer at Khmer-Soviet Friendship Hospital in Phnom Penh, Cambodia

Characteristics of Liver Cancer at Khmer-Soviet Friendship Hospital in Phnom Penh, Cambodia

Aflatoxin-Induced TP53 R249S Mutation in HepatoCellular Carcinoma in Thailand: Association with Tumors Developing in the Absence of Liver Cirrhosis

Risk Factors for the Development of Hepatocellular Carcinoma in Thailand

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