“…In all familial cases, the trait was inherited in an autosomal dominant fashion. A succession of follow-up reports established new cases and recalled a fascinating series of historical precedents by retrospective diagnosis (Kaur et al, 1972;Robinson et al, 1983;Biron et al, 1989;Ballas et al, 1990;Couderc et al, 1992;Horwitz et al, 1996;Wendland et al, 2000;Khanjari et al, 2003;Witzke et al, 2004;Bodor et al, 2012;Holme et al, 2012;Ishida et al, 2012;Kazenwadel et al, 2012;Camargo et al, 2013;Mace et al, 2013;Mutsaers et al, 2013;Niimi et al, 2013;Pasquet et al, 2013;Chou et al, 2014;Gao et al, 2014;West et al, 2014). The first we are aware of was a report in this journal in 1972, describing an Icelandic family with MDS/AML in association with trisomy 8 and PelgerHuet abnormality (Kaur et al, 1972), subsequently traced two generations later to a GATA2 T354M mutation (Dickinson et al, 2014).…”