Mutations associated with fungicide resistance in Colletotrichum species: A Review

Cortaga, Cris Q.; Cordez, Benjamine William P.; Dacones, Leilani S.; Balendres, Mark Angelo; Cueva, Fe M. Dela

doi:10.1007/s12600-023-01063-0

Cited by 13 publications

(5 citation statements)

References 81 publications

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“…Genomic analysis has allowed the determination of single mutations in amino acid residues in tubulin, mitochondrial cytochrome B, and sterol 14α-demethylase as responsible for the Colletotrichum fungicide resistance. These mutations are related to the uproper binding between fungal proteins and agrochemicals [ 55 ]. On the other hand, since it was launched in 1948, there have not been reports on the resistance of fungal phytopathogens against mancozeb in spite of being a fungicide applied to several crops [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Antifungal Activity of Menisporopsin A against Relevant Plant Pathogens

Rodriguez,

Barrios-Jaén,

Mejía

et al. 2024

JoF

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Current agrochemicals used in crop farming mainly consist of synthetic compounds with harmful effects on the environment and human health. Crop-associated fungal endophytes, which play many ecological roles including defense against pathogens, represent a promising source for bioactive and ecologically safer molecules in agrochemical discovery. The methanolic extract of the endophyte Menisporopsis sp. LCM 1078 was evaluated in vitro against the plant pathogens Boeremia exigua, Calonectria variabilis, Colletotrichum theobromicola, Colletotrichum tropicale, and Mycena cytricolor. Bioassay-guided isolation using chromatographic techniques followed by detailed chemical characterization by NMR and mass spectrometry led to the identification of menisporopsin A, which showed inhibitory activity in a dose-dependent manner against the five fungal pathogens including an endophytic strain (Colletotrichum tropicale), with MIC values in the range of 0.63–10.0 μg/mL showing a potency equivalent to the broadly employed agrochemical mancozeb.

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Section: Discussionmentioning

confidence: 99%

Antifungal Activity of Menisporopsin A against Relevant Plant Pathogens

Rodriguez,

Barrios-Jaén,

Mejía

et al. 2024

JoF

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“…Mutations in the sterol 14α-demethylases (CYP51A and CYP51B) gene conferred DMI fungicide resistance to the C. gloeosporioides from grapes [139]. Mutations associated with fungicide resistance in Colletotrichum were documented in Cortaga et al (2023) [143].…”

Section: Resistance To Fungicidesmentioning

confidence: 99%

“…Knowing the sensitivity differences of fungicides can assist in planning effective management schemes [19]. Strategies such as the alternate application and combined application of fungicides with different modes of action could help reduce the risk of fungicide resistance among grape ripe rot pathogens [143]. The appropriate combination of fungicides may also enhance efficacy through synergistic effects for disease management [144].…”

Section: Integrated Management Of Grape Ripe Rot Diseasementioning

confidence: 99%

Insights into Grape Ripe Rot: A Focus on the Colletotrichum gloeosporioides Species Complex and Its Management Strategies

Hsieh¹,

Shen

Huang³

et al. 2023

Plants

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Grape ripe rot, which is predominantly caused by the Colletotrichum species, presents a growing threat to global grape cultivation. This threat is amplified by the increasing populations of the Colletotrichum species in response to warmer climates. In this review, we investigate the wide-ranging spectrum of grape ripe rot, specifically highlighting the role and characteristics of the C. gloeosporioides species complex (CGSC). We incorporate this understanding as we explore the diverse symptoms that lead to infected grapevines, their intricate life cycle and epidemiology, and the escalating prevalence of C. viniferum in Asia and globally. Furthermore, we delve into numerous disease management strategies, both conventional and emerging, such as prevention and mitigation measures. These strategies include the examination of host resistances, beneficial cultivation practices, sanitation measures, microbiome health maintenance, fungicide choice and resistance, as well as integrated management approaches. This review seeks to enhance our understanding of this globally significant disease, aspiring to assist in the development and improvement of effective prevention and control strategies.

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“…Chemical control, such as chemical fungicides (e.g., benzimidazoles, thiabendazole, benomyl and carbendazim) and sterol inhibitors (e.g., imazalil, prochloraz and propiconazole), is currently an effective approach to control the anthracnose [10,11]. However, large-scale and continuous application of fungicides is detrimental to the environment and lead to pathogen resistance [11][12][13]. Therefore, eco-friendly means of disease control are urgently required.…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic and Physiological Analysis of the Effects of Exogenous Phloretin and Pterostilbene on Resistance Responses of Stylosanthes against Anthracnose

Zhang,

Xu,

Wang

et al. 2024

IJMS

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Anthracnose caused by Colletotrichum gloeosporioides is a destructive disease of Stylosanthes (stylo). Combination treatment of phloretin and pterostilbene (PP) has been previously shown to effectively inhibit the conidial germination and mycelial growth of C. gloeosporioides in vitro. In this study, the effects of PP treatment on the growth of C. gloeosporioides in vivo and the biocontrol mechanisms were investigated. We found that exogenous PP treatment could limit the growth of C. gloeosporioides and alleviate the damage of anthracnose in stylo. Comparative transcriptome analysis revealed that 565 genes were up-regulated and 239 genes were down-regulated upon PP treatment during the infection by C. gloeosporioides. The differentially expressed genes were mainly related to oxidative stress and chloroplast organization. Further physiological analysis revealed that application of PP after C. gloeosporioides inoculation significantly reduced the accumulation of O2•− level and increased the accumulation of antioxidants (glutathione, ascorbic acid and flavonoids) as well as the enzyme activity of total antioxidant capacity, superoxide dismutase, catalase, glutathione reductase, peroxidase and ascorbate peroxidase. PP also reduced the decline of chlorophyll a + b and increased the content of carotenoid in response to C. gloeosporioides infection. These results suggest that PP treatment alleviates anthracnose by improving antioxidant capacity and reducing the damage of chloroplasts, providing insights into the biocontrol mechanisms of PP on the stylo against anthracnose.

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Mutations associated with fungicide resistance in Colletotrichum species: A Review

Cited by 13 publications

References 81 publications

Antifungal Activity of Menisporopsin A against Relevant Plant Pathogens

Antifungal Activity of Menisporopsin A against Relevant Plant Pathogens

Insights into Grape Ripe Rot: A Focus on the Colletotrichum gloeosporioides Species Complex and Its Management Strategies

Transcriptomic and Physiological Analysis of the Effects of Exogenous Phloretin and Pterostilbene on Resistance Responses of Stylosanthes against Anthracnose

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