Mutational spectrum of thalassemias in India

Panigrahi, Inusha; Marwaha, R. K.

doi:10.4103/0971-6866.32034

Cited by 34 publications

(29 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The incidence reported from Tamilnadu is the highest reported incidence from any of the regions. Similar results were observed from Haryana (57 %), Uttar Pradesh (58 %), and eastern India (72 %) which correlate with our studies [12,18,19].…”

Section: Ivs I-5 (G-c) Substitution Which Is Bsupporting

confidence: 92%

“…The percent prevalence of codon 15 (G-A) was 2 % in Haryana, 11 % in Punjab, 6 % in Uttar Pradesh. In Gujarat it was 1.5 %, and in Maharashtra it was 18 % [12,19,20]. 619 bp deletion was found only in three (2.3 %) of total subjects studied.…”

Section: Ivs I-5 (G-c) Substitution Which Is Bmentioning

confidence: 80%

“…Incidence of this mutation was observed throughout India, from north-west Pakistan to Bangladesh and Bengal, and from Punjab to Tamilnadu. The incidence of this mutation was found to be 20 % in Bengal, 10 % in Tamilnadu, in Maharashtra 7.2 %, in Haryana it was 9 %, 3 % in Uttar Pradesh, 6 % in Eastern India, 5 % in Punjab, and 2 % in western India [12,19].…”

Section: Ivs I-5 (G-c) Substitution Which Is Bmentioning

confidence: 95%

See 2 more Smart Citations

The Prevalence Of β-Thalassemia Mutations in South Western Maharashtra

Satpute¹,

Bankar

Momin

2012

Ind J Clin Biochem

View full text Add to dashboard Cite

Section: Ivs I-5 (G-c) Substitution Which Is Bsupporting

confidence: 92%

Section: Ivs I-5 (G-c) Substitution Which Is Bmentioning

confidence: 80%

Section: Ivs I-5 (G-c) Substitution Which Is Bmentioning

confidence: 95%

See 1 more Smart Citation

The Prevalence Of β-Thalassemia Mutations in South Western Maharashtra

Satpute¹,

Bankar

Momin

2012

Ind J Clin Biochem

View full text Add to dashboard Cite

“…2,3 The estimated prevalence of the thalassemia carrier state in India is 3.3% of its total population. 7,8 There is at present no systematic, large published study that has surveyed the prevalence rates of -thalassemia carrier within West Bengal state in eastern India. Population screening has identified the prevalence ofthalassemia trait as high as 17% in certain communities in India.…”

Section: Introductionmentioning

confidence: 98%

The Prevalence and Characterization of β-Thalassemia Trait by Using High-Performance Liquid Chromatography among the Rural Population in West Bengal, India

Maji

Mandal

Bera³

et al. 2014

Thalassemia Reports

View full text Add to dashboard Cite

Hemoglobinopathies, common genetic disorders of hemoglobin, can be prevented by population screening and genetic counseling. Identification of these disorders is immensely important epidemiologically and aid in prevention of more serious hemoglobin disorders. Thalassemia is the commonest monogenic disorder in India, which belongs to the thalassemia belt of the world. The present study was undertaken to find out the characteristics of -thalassemia trait and spectrum of this disorder among the rural population, screened under the hospital-based screening program in West Bengal, a state in eastern part of India. This study was carried out in school and college students, newly married couples and pregnant women after proper counseling in the rural areas of five southern districts of this state. Blood samples were tested by high-performance liquid chromatography. Total 1429 -thalassemia traits were detected by random screening from this population. The mean value of HbA 2 of the study population, having -thalassemia trait is 4.9%. The prevalence (10.5%) of -thalassemia trait in West Bengal is higher than other parts of the country. These data are likely to help us in future planning for screening programmes in rural areas of West Bengal, India.

show abstract

“…The majority of the Indian ancestors came from Uttar Pradesh, West Bengal, Bihar and Orissa in India with few hailing from South India [2,3]. In India the carrier rate for beta thalassaemia ranges from 3 to 17% whereas for alpha thalassaemia it ranges from 1 to 80% [4]. In Trinidad and Tobago these data are not available.…”

Section: Introductionmentioning

confidence: 99%