Mutational screening of RTK-BRAF genes in de novo adult acute myeloid leukemia

Gholami, Milad; Bayat, Sahar; Pashaiefar, Hossein; Pouriamanesh, Sara; Manoochehrabadi, Saba; Behjati, Farkhondeh; Mirfakhraie, Reza

doi:10.1016/j.genrep.2020.100904

Cited by 2 publications

(2 citation statements)

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“…14 43 44 45 In 2019, Gholami et al showed that CEPBA expression is raised in AML patients and higher CEPBA expression plays a significant role in AML pathogenesis. 46 Many miRNAs are known to be CEPBA downstream effectors. 46 For example, miR-223 activation via CEPBA plays a key role in neutrophil differentiation and function.…”

Section: Discussionmentioning

confidence: 99%

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Dysregulated Expression of MiR-19b, MiR-25, MiR-17, WT1, and CEBPA in Patients with Acute Myeloid Leukemia and Association with Graft versus Host Disease after Hematopoietic Stem Cell Transplantation

Saadi

Tahmasebijaroubi

Noshadi

et al. 2022

South Asian J Cancer

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Objectives Acute myeloid leukemia (AML) is a blood malignancy characterized by the proliferation of aberrant cells in the bone marrow and blood that interfere with normal blood cells. We have investigated whether changes in the level of micro-ribonucleic acid (miR)-19b, miR-17, and miR-25, Wilms' tumor (WT1), and CCAAT enhancer-binding protein α (CEBPA) genes expression affect disease prognosis and clinical outcome in AML patients. Materials and Methods The expression level of miR-19-b, miR-17, and miR-25, as well as WT1 and CEBPA genes in a group of patients and controls as well as different risk groups (high, intermediate, and favorite risk), M3 versus non-M3, and graft-versus-host disease (GvHD) versus non-GvHD patients were assessed using a quantitative SYBR Green real-time polymerase chain reaction method. Results When compared with the baseline level at the period of diagnosis before chemotherapy, the expression of miR-19b and miR-17 in AML patients increased significantly after chemotherapy. The level of miR-19b and miR-25 expression in AML patients with M3 and non-M3 French–American–British subgroups differ significantly. MiR-19b and miR-25 expression was elevated in GvHD patients, while miR-19b and miR-25 expression was somewhat decreased in GvHD patients compared with non-GvHD patients, albeit the difference was not statistically significant. Also, patients with different cytogenetic aberrations had similar levels of miR-19-b and miR-25 expression. Conclusion MiR-19b, miR-17, and miR-25 are aberrantly expressed in AML patients' peripheral blood leukocytes, which may play a role in the development of acute GvHD following hematopoietic stem cell transplantation.

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Section: Discussionmentioning

confidence: 99%

“…46 Many miRNAs are known to be CEPBA downstream effectors. 46 For example, miR-223 activation via CEPBA plays a key role in neutrophil differentiation and function. It has also been reported that in AML patients impaired CEPBA function leads to reduced expression of miR-29b which is a tumor suppressor gene.…”

Section: Discussionmentioning

confidence: 99%