Mutational Patterns and DNA Barcode for Diagnosing Chikungunya Virus

Kumar, C. Prasanna; John, B. Akbar; Khan, Salim; Lyla, P. S.; Kamaleson, A.S.

doi:10.3923/ijv.2011.42.52

Cited by 1 publication

(2 citation statements)

References 14 publications

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“…A previous study suggested that the nsP3 HVD 7 aa deletion is not an occasional event caused by viral culture in vitro, since it has been identified in many isolates from different regions [241]. Interestingly, CHIKV strains isolated from Malaysia have adapted more mutations than other strains from other locations [251]. This includes the nsP3 HVD 7 aa deletion event, which was found only in human isolates MY/06/37348 and MY/06/373750, and not monkey isolates M125, M127, M128, and M129.…”

Section: Indel Repetition and Duplication Events In Chikv Nsp3mentioning

confidence: 98%

“…The co-evolution is suggested to affect the aa phosphorylation and serine or threonine kinase activity [248,250,251]. The co-evolution interaction is also suggested to be involved in signal transduction-for example, in TGF-β signaling and NF-κB activation [252,253].…”

Section: Nsp3 Hvd Residues Predicted Co-evolving Partners Residues In Nsp3 Hvd Details and Suggested Functionsmentioning

confidence: 99%

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The Putative Roles and Functions of Indel, Repetition and Duplication Events in Alphavirus Non-Structural Protein 3 Hypervariable Domain (nsP3 HVD) in Evolution, Viability and Re-Emergence

Abdullah

Ahemad

Aliazis

et al. 2021

Viruses

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Alphavirus non-structural proteins 1–4 (nsP1, nsP2, nsP3, and nsP4) are known to be crucial for alphavirus RNA replication and translation. To date, nsP3 has been demonstrated to mediate many virus–host protein–protein interactions in several fundamental alphavirus mechanisms, particularly during the early stages of replication. However, the molecular pathways and proteins networks underlying these mechanisms remain poorly described. This is due to the low genetic sequence homology of the nsP3 protein among the alphavirus species, especially at its 3′ C-terminal domain, the hypervariable domain (HVD). Moreover, the nsP3 HVD is almost or completely intrinsically disordered and has a poor ability to form secondary structures. Evolution in the nsP3 HVD region allows the alphavirus to adapt to vertebrate and insect hosts. This review focuses on the putative roles and functions of indel, repetition, and duplication events that have occurred in the alphavirus nsP3 HVD, including characterization of the differences and their implications for specificity in the context of virus–host interactions in fundamental alphavirus mechanisms, which have thus directly facilitated the evolution, adaptation, viability, and re-emergence of these viruses.

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Section: Indel Repetition and Duplication Events In Chikv Nsp3mentioning

confidence: 98%