Mutational escape prevention by combination of four neutralizing antibodies that target RBD conserved regions and stem helix

Tang, Haoneng; Ke, Yinghai; Liao, Yong; Bian, Yanlin; Yuan, Yunsheng; Wang, Ziqi; Li, Yang; Ma, Hang; Sun, Tao; Zhang, Baohong; Zhang, Xiaoju; Wu, Mingyuan; Zhu, Jianwei

doi:10.1016/j.virs.2022.11.005

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2023

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“…Although some cross-neutralizing antibodies targeting different conserved regions have been developed ( 22 – 26 ), more cross-neutralizing antibodies are needed to combat the emergence of SARS-CoV-2 VOCs. Combining neutralizing antibodies targeting different conserved regions could synergistically prevent the emergence of escape mutations ( 27 ). In this study, we provide a new conserved neutralizing target region that could be beneficial for epitope-based therapeutics and vaccine development.…”

Section: Discussionmentioning

confidence: 99%