Mutational, epigenetic and expressional analyses of caveolin-1 gene in breast cancers.

Chen, Shou Tung; Lin, Syh Yi; Yeh, Kun Tu; Kuo, Shou Jen; Chan, Wen Ling; Chu, Yen Ping; Chang, Jui‐Hsing

doi:10.3892/ijmm.14.4.577

Cited by 42 publications

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“…Despite the controversy about the distribution of CAV1 and CAV2 in normal and invasive breast cancer (Yang et al, 1998;Hurlstone et al, 1999;Chen et al, 2004;Sagara et al, 2004;Park et al, 2005; Van den Eynden et al, 2006), recent studies confirmed the preferential expression of both genes and their proteins in normal myoepithelial cells (Pinilla et al, 2006;Savage et al, 2007Savage et al, , 2008. Furthermore Savage et al, have recently reported high prevalence of CAV1 and CAV2 expression in basal-like breast carcinomas (Savage et al, , 2008, and observed CAV1 gene amplification in a small subgroup of basal-like breast cancers (Savage et al, , 2008.…”

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confidence: 66%

“…Caveolin-1 was first thought to have tumour suppressor properties (Razani et al, 2001a, b;Hnasko and Lisanti, 2003), based on the finding of an arguable inactivating point mutation in CAV1, the silencing of CAV1 gene expression by promoter hypermethylation in breast cell lines and prostate tumour samples (Engelman et al, 1999;Hurlstone et al, 1999;Cui et al, 2001) and the apparent downregulation of CAV1 in breast cancer (Chen et al, 2004;Park et al, 2005). In recent years, there has been increasingly more coherent data to suggest that CAV1 and CAV2 may also have oncogenic properties in breast (Hurlstone et al, 1999;Pinilla et al, 2006; Van den Eynden et al, 2006;Savage et al, 2007Savage et al, , 2008, prostate (Yang et al, 1998;Thompson et al, 1999), bladder (Rajjayabun et al, 2001;Fong et al, 2003), oesophageal (Kato et al, 2002;Ando et al, 2007), thyroid, pancreatic, non-small cell and squamous lung cancer (Kato et al, 2004;Sunaga et al, 2004).…”

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confidence: 99%

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Caveolin 1 and Caveolin 2 are associated with breast cancer basal-like and triple-negative immunophenotype

et al. 2008

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Caveolin-1 (CAV1) and caveolin 2 (CAV2) are the principal structural proteins of caveolae, sphingolipid and cholesterol-rich invaginations of the plasma membrane involved in vesicular trafficking and signal transduction. Over the recent years there has been controversy about their role in breast cancer and their suitability as markers of basal-like phenotype. Caveolin-1 and CAV2 protein expression was assessed on a tissue microarray containing 880 unselected invasive breast cancer cases, by means of immunohistochemistry. Caveolin-1 and CAV2 expression was observed in 13.4 and 5.9% of all breast cancer, respectively. Their expression was strongly associated with high histological grade, lack of steroid hormone receptor positivity (ER and PR), and expression of basal markers (basal cytokeratins, P63, P-cadherin). Furthermore, there was a significant association between CAV1 and CAV2 expression and basal-like phenotype. On univariate analysis only CAV2 had a prognostic impact on breast cancer-specific survival; however, this was not independent from other traditional markers on multivariate analysis. Our results demonstrate that both CAV1 and CAV2 are associated with basal-like phenotype. Further studies are warranted to determine whether they play an oncogenic role in basal-like/triple-negative breast cancer development or are just surrogate markers for this subgroup.

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confidence: 66%

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confidence: 99%

Caveolin 1 and Caveolin 2 are associated with breast cancer basal-like and triple-negative immunophenotype

et al. 2008

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“…Indeed, alteration/disruption of caveolin expression has been implicated, breast cancer [55][56][57], vascular abnormalities [58][59][60], pulmonary malfunction [33], and muscle disease [35,37].…”

Section: Caveolins: Important For the Trafficking And Clustering Of Mmentioning

confidence: 99%

Caveolin proteins and estrogen signaling in the brain

Luoma

Boulware

Mermelstein

2008

Molecular and Cellular Endocrinology

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Best described outside the nervous system, caveolins are structural proteins that form caveolae, functional microdomains at the plasma membrane that cluster related signaling molecules. Caveolin associated proteins include G protein coupled receptors and G proteins, receptor tyrosine kinases, as well as protein kinases, ion channels and various other signaling enzymes. Not surprisingly, a wide array of biological disorders are thought to be rooted in caveolin dysfunction. In addition, caveolins also traffic and cluster estrogen receptors to caveolae. Interactions between the estrogen receptors ERα and ERβ with caveolins appear critical in many non-neuronal cell types, e.g. disruption of normal function may underlie many forms of breast cancer. Recent findings suggest caveolins may also play an essential role in membrane estrogen receptor function in the nervous system. Not only are they expressed in neurons and glia, but different caveolin isoforms also appear necessary to generate distinct functional signaling complexes. With membrane estrogen receptors responsible for the efficient activation of a multitude of intracellular signaling pathways, which in turn influence a wide variety of nervous system functions, caveolin proteins are poised to act as the central coordinators of these processes.

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“…Caveolae are enriched by sphingolipids and cholesterol (Zhu et al, 2008) and are directly involved in vesicular trafficking and signal transduction (Bouras et al, 2004;Chen et al, 2004;Elsheikh et al, 2008). Caveolae and caveolins have several functions including vesicular transport, cholesterol homeostasis, signal transduction, and tumor suppression (Bat'ová et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical and molecular analysis of caveolin-1 expression in canine mammary tumors

Zuccari¹,

Castro²,

Gavioli³

et al. 2012

Genet. Mol. Res.

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ABSTRACT. Caveolin-1 (Cav-1) is a structural protein present in invaginations of the cell membrane. In human breast cancer, the cav-1 gene is believed to be a tumor suppressor gene associated with inhibition of tumor metastasis. However, little is known about its expression, regulation and function in canine mammary tumors. Expression levels of cav-1 were investigated using real-time PCR and immunohistochemical detection with an anti-human Cav-1 antibody. Gene expression stability of different samples was analyzed using the geNorm software. Mammary tumors from 51 female dogs were compared to normal mammary tissue from 10 female dogs. Malignant mammary cells showed a loss of Cav-1 expression by quantitative RT-PCR and weak Cav-1 staining by immunohistochemistry compared to normal mammary gland tissue. There was a significant relationship between outcome and immunostaining as well as with tumor size, indicating that caveolin subexpression has a positive predictive value and is related to higher survival and smaller tumor size. Our findings indicate that Cav-1 is a potential prognostic marker for canine mammary tumors.

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Mutational, epigenetic and expressional analyses of caveolin-1 gene in breast cancers.

Cited by 42 publications

References 0 publications

Caveolin 1 and Caveolin 2 are associated with breast cancer basal-like and triple-negative immunophenotype

Caveolin 1 and Caveolin 2 are associated with breast cancer basal-like and triple-negative immunophenotype

Caveolin proteins and estrogen signaling in the brain

Immunohistochemical and molecular analysis of caveolin-1 expression in canine mammary tumors

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