Abstract:1The analysis of the genome sequence of Yersinia mollaretii (Y. mollaretii) ATCC 43969 indicates 2 the presence of the bla YEM gene coding for YEM-1, a putative subclass B2 metallo-β-lactamase. The 3 objectives of our work were to produce, purify and complete the kinetic characterization of Compared to the known subclass B2 metallo−β-lactamases, YEM-1 displayed a narrowest substrate 5 profile since it is only able to hydrolyse imipenem with a high catalytic efficiency but not all the 6 other carbapenems teste… Show more
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