Mutational analysis of the human complement 5a receptor: Identification of a potential role of asp 37 and asp 82 in ligand binding

Abstract

The receptor for the inflammatory and chemotactic agent complement 5a (C5a) is a member of the G-protein coupled receptor (CPCR) superfamily. Site-directed mutagenesis of the human C5a receptor was performed to determine which amino acids were important for ligand binding.