Mutational analysis in Corynebacterium stationis MFS transporters for improving nucleotide bioproduction
Keita Kinose,
Keiko Shinoda,
Tomoyuki Konishi
et al.
Abstract:Product secretion from an engineered cell can be advantageous for microbial cell factories. Extensive work on nucleotide manufacturing, one of the most successful microbial fermentation processes, has enabled Corynebacterium stationis to transport nucleotides outside the cell by random mutagenesis; however, the underlying mechanism has not been elucidated, hindering its applications in transporter engineering. Herein, we report the nucleotide-exporting major facilitator superfamily (MFS) transporter from the C… Show more
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