Mutation of OsALDH7 causes a yellow-colored endosperm associated with accumulation of oryzamutaic acid A in rice

Shen, Yi; Zhang, Yan; Yang, Chao; Lan, Ying; Liu, Linglong; Liu, Shijia; Chen, Zhijun; Ren, Guixin; Wan, Jianmin

doi:10.1007/s00425-011-1477-x

Cited by 22 publications

(10 citation statements)

References 48 publications

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“…Mutant seeds accumulate malondialdehyde and yellow pigment named oryzamutaic acid A, a product of aminoadipic semialdehyde polymerization (Shen et al 2012; Shin et al 2009). Unfortunately, studies have yet to look at the comprehensive substrate specificity of plant ALDH7 homologues.…”

Section: Aldh7 Familymentioning

confidence: 99%

Aldehyde dehydrogenase (ALDH) superfamily in plants: gene nomenclature and comparative genomics

Brocker

Vasiliou

Carpenter

et al. 2012

Planta

140

154

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In recent years, there has been a significant increase in the number of completely sequenced plant genomes. The comparison of fully sequenced genomes allows for identification of new gene family members, as well as comprehensive analysis of gene family evolution. The aldehyde dehydrogenase (ALDH) gene superfamily comprises a group of enzymes involved in the NAD+- or NADP+-dependent conversion of various aldehydes to their corresponding carboxylic acids. ALDH enzymes are involved in processing many aldehydes that serve as biogenic intermediates in a wide range of metabolic pathways. In addition, many of these enzymes function as ‘aldehyde scavengers’ by removing reactive aldehydes generated during the oxidative degradation of lipid membranes, also known as lipid peroxidation. Plants and animals share many ALDH families, and many genes are highly conserved between these two evolutionarily distinct groups. Conversely, both plants and animals also contain unique ALDH genes and families. Herein we carried outgenome-wide identification of ALDH genes in a number of plant species—including Arabidopsis thaliana (thale crest), Chlamydomonas reinhardtii (unicellular algae), Oryza sativa (rice), Physcomitrella patens (moss), Vitis vinifera (grapevine) and Zea mays (maize). These data were then combined with previous analysis of Populus trichocarpa (poplar tree), Selaginella moellindorffii (gemmiferous spikemoss), Sorghum bicolor (sorghum) and Volvox carteri (colonial algae) for a comprehensive evolutionary comparison of the plant ALDH superfamily. As a result, newly identified genes can be more easily analyzed and gene names can be assigned according to current nomenclature guidelines; our goal is to clarify previously confusing and conflicting names and classifications that might confound results and prevent accurate comparisons between studies.

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Section: Aldh7 Familymentioning

confidence: 99%

Aldehyde dehydrogenase (ALDH) superfamily in plants: gene nomenclature and comparative genomics

Brocker

Vasiliou

Carpenter

et al. 2012

Planta

140

154

View full text Add to dashboard Cite

show abstract

“… 4 ). However, the mere transformation of the aldehyde into carboxylic acid often fails to explain how some ALDH genes are involved in complex phenotypes such as the nuclear restoration of cytoplasmic male sterility 12 , 13 , submergence tolerance 14 , seed maturation 15 , 16 , and cell proliferation 17 . Although the ALDHs use NAD + or NADP + as cofactors and generate NADH or NADPH, studies on both plant and animal ALDHs have only focused on their role in detoxifying toxic aldehydes, and have so far overlooked the potential contribution of the ALDH activity to the cellular NAD(P)H pools and NAD(P)H/NA(D)P ratio.…”

Section: Introductionmentioning

confidence: 99%

Aldehyde Dehydrogenases Function in the Homeostasis of Pyridine Nucleotides in Arabidopsis thaliana

Missihoun

Kotchoni

Bartels

2018

Sci Rep

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Aldehyde dehydrogenase enzymes (ALDHs) catalyze the oxidation of aliphatic and aromatic aldehydes to their corresponding carboxylic acids using NAD+ or NADP+ as cofactors and generating NADH or NADPH. Previous studies mainly focused on the ALDH role in detoxifying toxic aldehydes but their effect on the cellular NAD(P)H contents has so far been overlooked. Here, we investigated whether the ALDHs influence the cellular redox homeostasis. We used a double T-DNA insertion mutant that is defective in representative members of Arabidopsis thaliana ALDH families 3 (ALDH3I1) and 7 (ALDH7B4), and we examined the pyridine nucleotide pools, glutathione content, and the photosynthetic capacity of the aldh mutants in comparison with the wild type. The loss of function of ALDH3I1 and ALDH7B4 led to a decrease of NAD(P)H, NAD(P)H/NAD(P) ratio, and an alteration of the glutathione pools. The aldh double mutant had higher glucose-6-phosphate dehydrogenase activity than the wild type, indicating a high demand for reduced pyridine nucleotides. Moreover, the mutant had a reduced quantum yield of photosystem II and photosynthetic capacity at relatively high light intensities compared to the wild type. Altogether, our data revealed a role of ALDHs as major contributors to the homeostasis of pyridine nucleotides in plants.

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“…ALDHs catalyze oxidation of α-aminoadipic semialdehyde during lysine degradation. Additionally, they are upregulated in Arabidopsis anthers and can eliminate lesions induced by toxic aldehydes and reactive oxygen species ( Shin et al, 2009 ; Brocker et al, 2010 ; Shen et al, 2012 ; Hou and Bartels, 2015 ; Zhao et al, 2018 ). In maize T-CMS, the restorer gene RF2 encodes an ALDH that can complement the lack of ALDH activity in its mitochondria to reverse the male sterility caused by the CMS protein URF13 ( Liu et al, 2001 ).…”

Section: Discussionmentioning

confidence: 99%

Unraveling the Genetic Basis of Fertility Restoration for Cytoplasmic Male Sterile Line WNJ01A Originated From Brassica juncea in Brassica napus

Yang

Nong

et al. 2021

Front. Plant Sci.

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Crosses that lead to heterosis have been widely used in the rapeseed (Brassica napus L.) industry. Cytoplasmic male sterility (CMS)/restorer-of-fertility (Rf) systems represent one of the most useful tools for rapeseed production. Several CMS types and their restorer lines have been identified in rapeseed, but there are few studies on the mechanisms underlying fertility restoration. Here, we performed morphological observation, map-based cloning, and transcriptomic analysis of the F2 population developed by crossing the CMS line WNJ01A with its restorer line Hui01. Paraffin-embedded sections showed that the sporogenous cell stage was the critical pollen degeneration period, with major sporogenous cells displaying loose and irregular arrangement in sterile anthers. Most mitochondrial electron transport chain (mtETC) complex genes were upregulated in fertile compared to sterile buds. Using bulked segregant analysis (BSA)-seq to analyze mixed DNA pools from sterile and fertile F2 buds, respectively, we identified a 6.25 Mb candidate interval where Rfw is located. Using map-based cloning experiments combined with bacterial artificial chromosome (BAC) clone sequencing, the candidate interval was reduced to 99.75 kb and two pentatricopeptide repeat (PPR) genes were found among 28 predicted genes in this interval. Transcriptome sequencing showed that there were 1679 DEGs (1023 upregulated and 656 downregulated) in fertile compared to sterile F2 buds. The upregulated differentially expressed genes (DEGs) were enriched in the Kyoto Encyclopedia of Genes and Genomes (KEGG) lysine degradation pathway and phenylalanine metabolism, and the downregulated DEGs were enriched in cutin, suberine, and wax biosynthesis. Furthermore, 44 DEGs were involved in pollen and anther development, such as tapetum, microspores, and pollen wall development. All of them were upregulated except a few such as POE1 genes (which encode Pollen Ole e I allergen and extensin family proteins). There were 261 specifically expressed DEGs (9 and 252 in sterile and fertile buds, respectively). Regarding the fertile bud-specific upregulated DEGs, the ubiquitin–proteasome pathway was enriched. The top four hub genes in the protein–protein interaction network (BnaA09g56400D, BnaA10g18210D, BnaA10g18220D, and BnaC09g41740D) encode RAD23d proteins, which deliver ubiquitinated substrates to the 26S proteasome. These findings provide evidence on the pathways regulated by Rfw and improve our understanding of fertility restoration.

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Mutation of OsALDH7 causes a yellow-colored endosperm associated with accumulation of oryzamutaic acid A in rice

Cited by 22 publications

References 48 publications

Aldehyde dehydrogenase (ALDH) superfamily in plants: gene nomenclature and comparative genomics

Aldehyde dehydrogenase (ALDH) superfamily in plants: gene nomenclature and comparative genomics

Aldehyde Dehydrogenases Function in the Homeostasis of Pyridine Nucleotides in Arabidopsis thaliana

Unraveling the Genetic Basis of Fertility Restoration for Cytoplasmic Male Sterile Line WNJ01A Originated From Brassica juncea in Brassica napus

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