Mutation of a highly conserved amino acid in RPM1 causes leaf yellowing and premature senescence in wheat

Zhang, Wenjia; Zhang, Zhaoheng; Chen, Qian; Wang, Zihao; Song, Wanjun; Yang, Kai; Xin, Mingming; Hu, Zhaorong; Liu, Jie; Peng, Huiru; Lai, Jinsheng; Guo, Weilong; Ni, Zhongfu; Sun, Qixin; Du, Jinkun; Yao, Yingyin

doi:10.1007/s00122-023-04499-4

Theor Appl Genet

2023

DOI: 10.1007/s00122-023-04499-4

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Mutation of a highly conserved amino acid in RPM1 causes leaf yellowing and premature senescence in wheat

Wenjia Zhang,

Zhaoheng Zhang,

Qian Chen

et al.

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2024

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Cited by 1 publication

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In-silico analysis of nsSNPs in human CYP3A4/5 and their effects on drug-enzymes interactions of FDA-approved COVID-19 antiviral drugs: A pharmacogenetic study

Abdelazim,

Maged,

Abdelmaksoud

et al. 2024

Preprint

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Single nucleotide polymorphisms (SNPs) represent the prevailing form of genetic variations observed in the human population. Such variations could alter the encoded enzymes’ activities. CYP3A4/5 enzymes have a pivotal role in metabolising drugs, notably antivirals against SARS-CoV-2. In this work we computationally investigated antiviral-enzyme interactions of CYP3A4/5 genetic variants. We also examined the deleterious impact of 751 non-synonymous single nucleotide polymorphisms (nsSNPs) within the CYP3A4/5 genes. An ensemble of bioinformatics tools, [SIFT, PolyPhen, cadd, revel, metaLr, mutation assessor, Panther, SNP&GO, PhD-SNP, SNAP, Meta-SNP, FATHMM, I-Mutante, MuPro, INPS, CONSURF, GPS 5.0, MusiteDeep and NetPhos], identified a total of 94 variants (47 nsSNPs in CYP3A4, 47 nsSNPs in CYP3A5) to potentially impact the structural integrity as well as the activity of the CYP3A4/5 enzymes. Molecular docking was done to recognize the structural stability and binding properties of the CYP3A4/5 protein isoforms with 3 FDA-approved antiviral drugs. It was concluded that for the gene CYP3A4; the variants R418T, I335T and R130P while the CYP3A5 SNPs; I335T, L133P and R130Q are considered the most deleterious nsSNPs, potentially affecting drug-binding. Cataloguing deleterious SNPs is vital for personalized gene-based pharmacotherapy.

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In-silico analysis of nsSNPs in human CYP3A4/5 and their effects on drug-enzymes interactions of FDA-approved COVID-19 antiviral drugs: A pharmacogenetic study

Abdelazim,

Maged,

Abdelmaksoud

et al. 2024

Preprint

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show abstract

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Mutation of a highly conserved amino acid in RPM1 causes leaf yellowing and premature senescence in wheat

Cited by 1 publication

References 46 publications

In-silico analysis of nsSNPs in human CYP3A4/5 and their effects on drug-enzymes interactions of FDA-approved COVID-19 antiviral drugs: A pharmacogenetic study

In-silico analysis of nsSNPs in human CYP3A4/5 and their effects on drug-enzymes interactions of FDA-approved COVID-19 antiviral drugs: A pharmacogenetic study

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