Mutation in BMPR-IB gene is associated with litter size in Iranian Kalehkoohi sheep

Detection of polymorphism in booroola gene and growth differentiation factor 9 in Lori sheep breed

“…In contrast to these reports, Moradband et al [3] observed that, all three possible genotypes for the GDF9 are present in Baluchi sheep population. Also, our findings are in conflict with Mahdavi et al [10] who reported that the BB, B+ and ++ genotypes have been identified in Kalehkoohi sheep breed 0.13, 0.446 and 0.424, respectively. In fact, this is the first report of homozygous carriers of the FecB gene in Iranian sheep breeds.…”

“…In fact, this is the first report of homozygous carriers of the FecB gene in Iranian sheep breeds. Mahdavi et al [10] pointed out that the result of their study support the concept that BMPR-IB significantly affected litter size and thus it could be used for marker assisted selection programmers for the genetic improvement of reproductive characteristics in this breed.…”

“…In contrast to this report, Bahrami et al [9] and Kasiriyan et al [6] observed that populations of Hisari and Sangsari sheep were in the Hardy-Weinberg equilibrium at the GDF9 locus. Also, another study showed that the population of Kalehkoohi sheep breed at the FecB locus was not found to follow the Hardy-Weinberg equilibrium [10].…”

“…In recent years, a number of natural genetic mutations have been identifiedin the bone morphogenetic protein (BMPR1B or FecB) and the growth differentiation factor 9 (GDF9) genes [2][3][4][5][6][7][8][9][10]. These genes were selected again to detect the probably effects on sheep prolificacy.…”

The genetic diversity of both FecB gene and microsatellite GC101is associated with reproduction selection in sheep

“…The genotypes of FecB gene in ewes have been classified as homozygous noncarriers (++), with the ovulation rate of two or less; heterozygous carriers (B+), with the ovulation rate of three to four; and homozygous carriers (BB), with more than five ovulations per estrous cycle (5,6). FecB mutation was present in many sheep breeds, such as Booroola Merino (Australia) (1,4), Garole (India) (7), Javanese (Indonesia) (7), Kendrapada (India) (8), Bonpala (India) (9), Kalehkoohi (Iran) (10), Small Tail Han (China) (11,12), Hu (China) (12,13), prolific strains of Chinese Merino (China) (14), Duolang (China) (15), Cele (China) (16), Wadi (China) (17), Altay (China) (18), and Bayanbulak sheep (China) (19). Now the FecB is one of most important fecundity markers widely used in sheep breeding.…”