Mutation Endmember Library Sparse Mixed Abundance Estimation Model for Glioma Margin Determination with Raman Spectroscopy
Qingbo Li,
Jianwen Wang
Abstract:The glioma margin is a region of brain tissue where glioblastoma tissue transitions to normal tissue with varying levels of cancer cell concentration. This article uses Raman spectroscopy to detect the glioma margin, which is a fuzzy and uncertain substance that cannot be accurately identified by conventional pattern recognition algorithms. This article applies abundance estimation to Raman spectral unmixing of glioma marginal tissues for the accurate and real-time determination of the tumor surgical boundary … Show more
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