Mutation analysis of tumor necrosis factor alpha-induced protein 3 gene in Hodgkin lymphoma

Etzel, Barbara-Magdalena; Gerth, Melanie; Chen, Yuan; Wünsche, Elisa; Facklam, Tina; Beck, James F.; Guntinas‐Lichius, Orlando; Petersen, Iver

doi:10.1016/j.prp.2016.11.001

Cited by 11 publications

(8 citation statements)

References 19 publications

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“…25 Another study found that TNFAIP3, as a tumor suppressor gene, may be a key molecule in the transformation of chronic inflammation into cancer. 62 In multiple myeloma cells, TNFAIP3 was found to be inactivated mainly because of deletions, not body mutations or promoter methylation. Inactivated TNFAIP3 could affect the activity of NF-κB signaling pathway and led to multiple myeloma, and it was suggested that TNFAIP3 might be a potential therapeutic target for multiple myeloma.…”

Section: Tnfaip3 and Malignant Tumorsmentioning

confidence: 99%

<p>Tumor Necrosis Factor Alpha-Induced Proteins in Malignant Tumors: Progress and Prospects</p>

Guo¹,

Yuan²

2020

OTT

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Tumor necrosis factor (TNF) is the first cytokine used in tumor biotherapy, but TNFrelated drugs are limited by the lack of specific targets. Tumor necrosis factor alpha-induced proteins (TNFAIPs), derived from TNF, is a protein family and participates in proliferation, invasion and metastasis of tumor cells. In order to better understand biological functions and potential roles of TNFAIPs in malignant tumors, this paper in the form of "Gene-Protein-Tumor correlation" summarizes the biological characteristics, physiological functions and mechanisms of TNFAIPs by searching National Center of Biotechnology Information, GeneCards, UniProt and STRING databases. The relationship between TNFAIPs and malignant tumors is analyzed, and protein-protein interaction diagram in members of TNFAIPs is drawn based on TNF for the first time. We find that TNF as a key factor is related to TNFAIP1, TNFAIP3, TNFAIP5, TNFAIP6, TNFAIP8 and TNFAIP9, which can be directly involved in activating TNFAIP1, TNFAIP5, TNFAIP8 and TNFAIP9. We confirm that the mechanism of TNFAIP1, TNFAIP2 and TNFAIP3 inducing tumors may be related to NF-κB signaling pathway, but the mechanism of tumor induction by other members of TNFAIPs is not clear. In the future, translational studies are needed to explore the mechanisms of TNF-TNFAIPs-tumors.

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Section: Tnfaip3 and Malignant Tumorsmentioning

confidence: 99%

<p>Tumor Necrosis Factor Alpha-Induced Proteins in Malignant Tumors: Progress and Prospects</p>

Guo¹,

Yuan²

2020

OTT

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“…Formalin-fixed paraffin-embedded (FFPE) tissues are a highly valuable source of genetic material for molecular analyses both in research and clinical diagnostics. In recent years, the use of FFPE tissues for molecular pathological detection, such as tumor-related gene mutations 1 and the molecular detection of targeted drugs, 2,3 has rapidly developed from scientific research to in vitro pathological diagnosis. Indeed, retrospective gene research is increasingly used in tumor molecular biology.…”

Section: Introductionmentioning

confidence: 99%

Effect of preservation time of formalin-fixed paraffin-embedded tissues on extractable DNA and RNA quantity

Yang

Shi

et al. 2020

J Int Med Res

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Objectives This study aimed to investigate the factors affecting the quantity of DNA and RNA extractable from human formalin-fixed paraffin-embedded (FFPE) tissues stored for different lengths of time. Methods We randomly selected 20 FFPE specimens harvested from hysteromyoma patients with uterine fibroids during 2010, 2015, and 2017 at the Department of Pathology, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences. DNA and RNA extractions were performed using a DNA/RNA FFPE kit. DNA and RNA concentrations and their OD260/OD280 ratios were determined by a NanoDrop 2000 spectrophotometer. The human β-globin gene and aldehyde dehydrogenase-2 (ALDH2) gene were amplified from nucleic acids using a LightCycler 480 Real-Time PCR System, and PCR amplification products were electrophoresed on 1% agarose gels. Results Specimens that were stored for longer showed more degradation and a reduced concentration of DNA and RNA after nucleic acid extraction. However, there was no significant difference in DNA or RNA purity. β-globin and ALDH2 genes could be amplified from more than 99% of specimens. Conclusion We found that FFPE tissues stored for longer had a reduced quantity of extractable DNA and RNA. However, these tissues could be used for the analysis of some small target genes.

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“…In fact, LMP1 could provide the signal for the activation of these pathways in the absence of mutations. This is well illustrated in the case of the TNFAIP3 gene which encodes a protein that is a negative regulator of NF-κB, and is almost always mutated only in EBV-negative cHL [ 125 , 126 ].…”

Section: Hodgkin Lymphoma (Hl)mentioning

confidence: 99%

Contribution of Epstein–Barr Virus Latent Proteins to the Pathogenesis of Classical Hodgkin Lymphoma

et al. 2018

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Pathogenic viruses have evolved to manipulate the host cell utilising a variety of strategies including expression of viral proteins to hijack or mimic the activity of cellular functions. DNA tumour viruses often establish latent infection in which no new virions are produced, characterized by the expression of a restricted repertoire of so-called latent viral genes. These latent genes serve to remodel cellular functions to ensure survival of the virus within host cells, often for the lifetime of the infected individual. However, under certain circumstances, virus infection may contribute to transformation of the host cell; this event is not a usual outcome of infection. Here, we review how the Epstein–Barr virus (EBV), the prototypic oncogenic human virus, modulates host cell functions, with a focus on the role of the EBV latent genes in classical Hodgkin lymphoma.

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Mutation analysis of tumor necrosis factor alpha-induced protein 3 gene in Hodgkin lymphoma

Cited by 11 publications

References 19 publications

<p>Tumor Necrosis Factor Alpha-Induced Proteins in Malignant Tumors: Progress and Prospects</p>

<p>Tumor Necrosis Factor Alpha-Induced Proteins in Malignant Tumors: Progress and Prospects</p>

Effect of preservation time of formalin-fixed paraffin-embedded tissues on extractable DNA and RNA quantity

Contribution of Epstein–Barr Virus Latent Proteins to the Pathogenesis of Classical Hodgkin Lymphoma

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