Mutasynthesis for Natural Product Bioengineering

Porterfield, William; Zhang, Wenjun

doi:10.1016/b978-0-12-409547-2.14633-5

Cited by 1 publication

(1 citation statement)

References 108 publications

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“…Recently, the genetic re-engineering of the echinocandin-producing organism displayed the advantage to obtain analogs with variations in the complex core structure . The progress in this field can accelerate the production of more analogs with diverse core structures which can provide invaluable information for expanding their antifungal SARs . Moreover, structural simplification of these complex natural products can be another useful strategy. , On the basis of the obtained SARs, ligand based computer-aided drug design (CADD) methods, such as pharmacophore, CoMFA, and ligand similarity, can also be helpful for further rational optimization.…”

Section: Perspectivesmentioning

confidence: 99%

Recent Progress in the Discovery of Antifungal Agents Targeting the Cell Wall

2020

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Due to the limit of available treatments and the emergence of drug resistance in the clinic, invasive fungal infections are an intractable problem with high morbidity and mortality. The cell wall, as a fungi-specific structure, is an appealing target for the discovery and development of novel and low-toxic antifungal agents. In an attempt to accelerate the discovery of novel cell wall targeted drugs, this Perspective will provide a comprehensive review of the progress made to date on the development of fungal cell wall inhibitors. Specifically, this review will focus on the targets, discovery process, chemical structures, antifungal activities, and structure–activity relationships. Although two types of cell wall antifungal agents are clinically available or in clinical trials, it is still a long way for the other cell wall targeted inhibitors to be translated into clinical applications. Future efforts should be focused on the identification of inhibitors against novel conserved cell wall targets.

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