Mutant p53 driven-LINC00857, a protein scaffold between FOXM1 and deubiquitinase OTUB1, promotes the metastasis of pancreatic cancer

Zhang, Weifan; Qian, Weikun; Gu, Jingtao; Gong, Mengyuan; Zhang, Wunai; Zhang, Simei; Zhou, Cancan; Jiang, Zhengdong; Jiang, Jie; Han, Liang; Wang, Xiaoqin; Wu, Zheng; Ma, Qingyong; Wang, Zheng

doi:10.1016/j.canlet.2022.215976

Cited by 20 publications

(12 citation statements)

References 42 publications

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“…Meanwhile, 14-3-3σ can also improve the stability and transcriptional activity of p53 in a feedback [ 35 ]. However, many studies confirmed that p53 is abnormally increased as mutant p53 forms in some tumor tissues or cells [ 36 ], and does not possess a negative regulatory effect on cell proliferation [ 37 , 38 ]. Some studies also confirmed that ALV-J infection can induce mutation of p53 gene and increase mRNA expression [ 13 , 39 ], and some mutant forms of p53 might be involved in the development of tumors induced by ALV-J [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

J Subgroup Avian Leukosis Virus Strain Promotes Cell Proliferation by Negatively Regulating 14-3-3σ Expressions in Chicken Fibroblast Cells

Wang

Sun

et al. 2023

Viruses

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This study focuses on clarifying the regulation of chicken 14-3-3σ protein on the fibrous histiocyte proliferation caused by ALV-J-SD1005 strain infection. DF-1 cells were inoculated with 102 TCID50 of ALV-J-SD1005 strain; the cell proliferation viability was dramatically increased and 14-3-3σ expressions were dramatically decreased within 48 hours after inoculation. Chicken 14-3-3σ over-expression could significantly decrease the cell proliferation and the ratio of S-phase cells, but increase the ratio of G2/M-phase cells in ALV-J-infected DF-1 cells; by contrast, chicken 14-3-3σ knockdown expression could cause the opposite effects. Additionally, chicken 14-3-3σ over-expression could also dramatically down-regulate the expressions of CDK2/CDC2, but up-regulate p53 expressions in the DF-1 cells; in contrast, the knockdown expression could significantly increase the expressions of CDK2/CDC2 and decrease p53 expressions. It can be concluded that chicken 14-3-3σ can inhibit cell proliferation and cell cycle by regulating CDK2/CDC2/p53 expressions in ALV-J-infected DF1 cells. ALV-J-SD1005 strain can promote cell proliferation by reducing 14-3-3σ expressions. This study helps to clarify the forming mechanism of acute fibrosarcoma induced by ALV-J infection.

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Section: Discussionmentioning

confidence: 99%

J Subgroup Avian Leukosis Virus Strain Promotes Cell Proliferation by Negatively Regulating 14-3-3σ Expressions in Chicken Fibroblast Cells

Wang

Sun

et al. 2023

Viruses

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“…For instance, LINC00857 acts as a protein scaffold by binding to both FOXM1 and OTUB1, thereby enhancing their interaction and inhibiting FOXM1 degradation through the ubiquitin-proteasome pathway. [51] The recruitment of CYLD to HOIP is facilitated by the adaptor protein SPATA2, which acts as a bridge between the DUB and HOIP (Figure 4B). [52] The length of Ub chains is distinguishable for linkage types and supplies one more variable.…”

Section: The Ubiquitin Linkage Specificity Of Dubsmentioning

confidence: 99%

Deubiquitylating Enzymes in Cancer and Immunity

Ren,

Yu,

Liu

et al. 2023

Advanced Science

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Deubiquitylating enzymes (DUBs) maintain relative homeostasis of the cellular ubiquitome by removing the post‐translational modification ubiquitin moiety from substrates. Numerous DUBs have been demonstrated specificity for cleaving a certain type of ubiquitin linkage or positions within ubiquitin chains. Moreover, several DUBs perform functions through specific protein–protein interactions in a catalytically independent manner, which further expands the versatility and complexity of DUBs’ functions. Dysregulation of DUBs disrupts the dynamic equilibrium of ubiquitome and causes various diseases, especially cancer and immune disorders. This review summarizes the Janus‐faced roles of DUBs in cancer including proteasomal degradation, DNA repair, apoptosis, and tumor metastasis, as well as in immunity involving innate immune receptor signaling and inflammatory and autoimmune disorders. The prospects and challenges for the clinical development of DUB inhibitors are further discussed. The review provides a comprehensive understanding of the multi‐faced roles of DUBs in cancer and immunity.

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“…[115] Mutant p53 drives LINC00857 as a protein scaffold to enhance the binding between FOXM1 and de-ubiquitinase OTUB1, thereby inhibiting FOXM1 degradation via the ubiquitin-proteasome pathway to promote cancer metastasis. [116] The oncogenic function of lncRNA SNHG15 has been detected in pancreatic cancer by epigenetically repressing P15 and Kruppel-like factor 2, competitively combining the enhancer of EZH2, and inducing histone H3 lysine 27 trimethylation. [117] Regarding epigenetic modifications, lncRNA expression levels are closely related to DNA methylation levels.…”

Section: Lncrna's Epigenetic Inheritance Transcription Post-transcrip...mentioning

confidence: 99%

The Expanding Roles of Long Non‐Coding RNAs in Pancreatic Cancer

Yan,

Wu,

Yang

et al. 2023

Advanced Therapeutics

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Pancreatic cancer is a clinically challenging disease with a poor survival rate and is one of the leading causes of cancer‐related morbidity. It is highly resistant to treatment and effective diagnostic tools during the early stages of the disease are lacking. Long non‐coding RNAs (lncRNAs) participate extensively in the physiological processes of various diseases, especially multiple types of cancers. lncRNAs have been shown to perform essential functions and are gaining increasing attention in pancreatic cancer research. This review summarizes the roles of lncRNAs in the occurrence, development, and therapeutic resistance of pancreatic cancer by categorizing their regulation of epigenetic inheritance, transcription, post‐transcription, and related signaling pathways. Potential clinical implications, including diagnostic and prognostic biomarkers, as well as the therapeutic prospects of these lncRNAs in pancreatic cancer, are also discussed. Novel insights into the role of lncRNAs in the pathogenesis of pancreatic cancer may help researchers develop novel therapeutic strategies.This article is protected by copyright. All rights reserved

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Mutant p53 driven-LINC00857, a protein scaffold between FOXM1 and deubiquitinase OTUB1, promotes the metastasis of pancreatic cancer

Cited by 20 publications

References 42 publications

J Subgroup Avian Leukosis Virus Strain Promotes Cell Proliferation by Negatively Regulating 14-3-3σ Expressions in Chicken Fibroblast Cells

J Subgroup Avian Leukosis Virus Strain Promotes Cell Proliferation by Negatively Regulating 14-3-3σ Expressions in Chicken Fibroblast Cells

Deubiquitylating Enzymes in Cancer and Immunity

The Expanding Roles of Long Non‐Coding RNAs in Pancreatic Cancer

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