“…Notably, a number of promoters that were reported to be regulated by bound mutp53 in other studies also overlap with CpG islands, e.g., MYC, 41 ID2, 42 ID4, 16 TWIST1, 9 EGR1, 22 MAP2K3, 43 target genes of the transcription factors VDR (CYP24A1) 14 and NF-Y (CCNA1, CCNB2, CDK1, CDC25C), 13 genes containing sterol regulatory elements in their promoters (CYP51A1, FDPS, FDFT1, HMGCR, HMGCS1, MVK, SQLE) 17 and the TDP2 gene. 18 G/C-rich DNA stretches are of particular interest regarding gene regulation. They are not only subjected to epigenetic control via cytosine methylation, but under favorable conditions (e.g., superhelical tension and stabilization by bound proteins), are also prone to form left-handed (Z), triplex (H), cruciform and G-quadruplex structures, which have been implied in transcriptional regulation.…”