2003
DOI: 10.1074/jbc.m303354200 View full text |Buy / Rent full text
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Abstract: Aggregation of huntingtin (htt) in neuronal inclusionsis associated with the development of Huntington's disease (HD). Previously, we have shown that mutant htt fragments with polyglutamine (polyQ) tracts in the pathological range (>37 glutamines) form SDS-resistant aggregates with a fibrillar morphology, whereas wildtype htt fragments with normal polyQ domains do not aggregate. In this study we have investigated the coaggregation of mutant and wild-type htt fragments. We found that mutant htt promotes the agg… Show more

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