“…Experimental evidence indicates that cohesin pathway is a convergent hub for many biological processes intrinsically connected: sister chromatid cohesion, genome organization, gene expression regulation, DNA repair, and genome safeguarding [Michaelis et al, ; Parelho et al, ; Bauerschmidt et al, ; Kagey et al, ; Caron et al, ; Cipressa et al, ; Gelot et al, ]. The identification of both germinal and somatic mutations in cohesin genes in human developmental disorders, collectively termed cohesinopathies [Krantz et al, ; Tonkin et al, ; Schule et al, ; Vega et al, ; Musio et al, ; Deardorff et al, , ,; van der Lelij et al, ; Chetaille et al, ; Kaiser et al, ], and cancers including colon and bladder cancer and leukemia [Barber et al, ; Solomon et al, ; Welch et al, ; Kon et al, ; Cucco et al, ], all characterized by GIN, indicates that cohesin may be a pivotal actor in preserving genome stability. Taking this information as guide, we review the ways that the study of cohesinopathies can contribute to our understanding of GIN mechanisms.…”