Mutagenicity studies on 2,4-dinitrotoluene

Hodgson, John; Kowalski, M.; Glennon, J.P.; Dacre, Jack C.; Lee, C.-C.

doi:10.1016/0165-1161(76)90111-4

Cited by 9 publications

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“…A recent study [Spanggord et al, in press] identified over 30 nitroaromatic components in wastewaters generated from the production and purification of 2,4,6-trinitrotoluene. This wastewater, termed "condensate wastewater," contains many isomeric trinitrotoluenes, dinitrotoluenes, and aminodinitrotoluenes, a few of which have been tested previously in the Ames Salmonella assay [Chiu et al, 1978;Couch et al, 1979;Hodgson et al, 1976;Whong et al;Won et al, 19761. The testing of these structurally related com-pounds under comparative conditions presented an opportunity to investigate structure-activity relationships involving the mutagenicity of selected polynitroaromatic compounds.…”

Section: Introductionmentioning

confidence: 99%

Mutagenicity in salmonella typhimurium and structure‐activity relationships of wastewater components emanating from the manufacture of trinitrotoluene

et al. 1982

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The mutagenicity of 36 polynitroaromatic compounds was investigated with five strains of Salmonella typhimurium. Isomeric trinitrotoluenes (TNT), with the exception of 2,4,6-TNT and 2,3,4-TNT, exhibit mutagenicity independently of nitroreductase enzymes, but isomeric aminodinitrotoluenes (ADNT) and isomeric dinitrotoluenes (DNT) need nitroreductase to induce mutation. Within groups of isomeric TNTs, DNTs, and ADNTs, mutagenic response was enhanced by a para orientation of nitro groups. The mutagenic response of isomeric DNTs was found to correlate with the compound's ability to undergo charge-transfer complexation with reductive enzymes, whereas further complexation (such as a Janovsky complex) appears to be required for inducing mutation in dinitrobenzenes. These results indicate that polynitroaromatic compounds in TNT wastewaters possess a significant potential for biologic activity.

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Section: Introductionmentioning

confidence: 99%

Mutagenicity in salmonella typhimurium and structure‐activity relationships of wastewater components emanating from the manufacture of trinitrotoluene

et al. 1982

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2,4‐Dinitrotoluene 121‐14‐2

2004

Sax's Dangerous Properties of Industrial Materials

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Dinitrotoluole (alle Isomeren in technischen Gemischen) [MAK Value Documentation in German language, 1986]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 11. Lieferung, Ausgabe 1986 Der Artikel enthält folgende Kapitel: Charakterisierung der einzelnen Dinitrotoluole und des Isomerengemisches Allgemeiner Wirkungscharakter Angaben zur Pharmakokinetik Untersuchungen zur Enzyminduktion Makromolekulare Bindung und DNA‐Reparatur Erfahrungen beim Menschen Tierexperimentelle Befunde Akute Toxizität Subchronische und chronische Toxizität Untersuchungen zur mutagenen, antifertilen und teratogenen Wirkung von DNT Mutagenitätsstudien/Ames Test Mutagenitätsstudien/Dominant‐Letal‐Test Mutagenitätsstudien/Zellkultur Teratogenitätsstudien Untersuchungen zur kanzerogenen Wirkung Maus Lungenadenom‐Test Initiations‐Promotions‐Studien Zur Frage eines MAK‐Wertes

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Mutagenicity studies on 2,4-dinitrotoluene

Cited by 9 publications

References 0 publications

Mutagenicity in salmonella typhimurium and structure‐activity relationships of wastewater components emanating from the manufacture of trinitrotoluene

Mutagenicity in salmonella typhimurium and structure‐activity relationships of wastewater components emanating from the manufacture of trinitrotoluene

2,4‐Dinitrotoluene 121‐14‐2

Dinitrotoluole (alle Isomeren in technischen Gemischen) [MAK Value Documentation in German language, 1986]

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