Mutagenicity of oxytetracycline

Blitek, D; Pieńkowska, K; Gajcy, H; Koziorowska, J

doi:10.1016/0165-1218(83)90167-2

Cited by 11 publications

(1 citation statement)

References 8 publications

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“…Tetracycline hydrochloride treatment by immersion, although less efficient as a disease protectant, might still prove to have side-effects. Some tetracycline compounds administered in high doses proved to be mutagenic to bacteria strains in mammals, and the mutagenicity test with the bone marrow cells was also positive (Blitek et al, 1983). This range of TC activity as an antibiotic substance is less known in fish and there is the possibility of nitrosation of TC compounds leading to formation of the carcinogenic and mutagenic substances like nitrsodimethylamine (Blitek et al, 1983).…”

Section: Discussionmentioning

confidence: 99%

Tetracycline tagging in coregonid embryos and larvae

Dąbrowski

Tsukamoto

1986

Journal of Fish Biology

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Coregonus peled(Gme1in) embryos at the eyed stage were immersed in tetracycline hydrochloride (TC) solution (600 mg 1-')and fluorescent marks on the otoliths from fish were identified under a UV light microscope. Three weeks after treatment, when the larval fish had hatched, multiple primordia of the sagitta had fluorescent bands whose locations suggest that calcification begins before formation of the otolith's core. Upon hatching, increments were few or absent, and daily increments started forming after hatching. In coregonid larvae immersed in TC solution immediately after hatching, the fluorescent band was only 1 day's growth increment wide in the otolith. The age of larvae based on ring counts after marking corresponded to the actual age, but further studies are required. Triple marks due to 35-h immersions in TC solution separated by 5-7 day feeding periods were clearly readable in the otoliths. One month after treatment the fluorescent marks were identified under UV light on otoliths from every fish. In treated embryos, 38% of fish had marks 3 months after TC immersion, whereas in treated larvae 6&80% of fish grown up to 38.7 mm were marked.

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Section: Discussionmentioning

confidence: 99%

Tetracycline tagging in coregonid embryos and larvae

Dąbrowski

Tsukamoto

1986

Journal of Fish Biology

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5‐Hydroxytetracycline Hydrochloride 2058‐46‐0

2004

Sax's Dangerous Properties of Industrial Materials

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Bone marrow micronucleus assay: A review of the mouse stocks used and their published mean spontaneous micronucleus frequencies

Salamone

Mavournin

1994

Environ and Mol Mutagen

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We have examined published negative control data from 581 papers on micronucleated bone marrow polychromatic erythrocytes (mnPCE) for differences in mean frequency and the frequency distribution profile among the mouse stocks used with the bone marrow micronucleus assay. For the 55 mouse stocks with published micronucleus assay data, the overall mean frequency is 1.95 mnPCE/1,000 PCE (1.95 mnPCE/1,000); for the 13 stocks most commonly used in the assay, it is 1.88 mnPCE/1,000. During the last 5 years, the mnPCE rate for these 13 major stocks has been 1.74 mnPCE/1,000. This current mean frequency is a substantial decrease from the mean of 3.07 mnPCE/1,000 observed for these 13 stocks for data published prior to 1981. Of the major stocks, the highest mean mnPCE negative control frequencies were observed for MS/Ae > BALB/c > C57Bl/6, and the lowest for CD-1 < Swiss Webster. We note that hybrid mouse stocks appear to have lower and less variable negative control frequencies than either of their parent strains and that the negative control frequency for some progeny stocks have diverged significantly from that of the parent stocks. Overall mean negative control frequencies appear to be correlated with breadth of the frequency distribution profile of published mean negative control values. Furthermore, a possible correlation between negative control frequency in the micronucleus assay and sensitivity to clastogens of different mouse strains may be indicated. The databases generated here allow us to define a range of norms for both the historical mean frequency and individual experimental mean frequencies for most stocks, but in particular, for the more commonly used mouse stocks. Our analysis, for the most part, bears out the recommendation of the first Gene-Tox Report on the micronucleus assay that the historical negative control frequency for a mouse stock should fall between 1 and 3 mnPCE/1,000. Eighty-six percent of the most commonly used mouse stocks have historical mean frequencies within this range. Though individual experimental mean values would not necessarily be expected to fall within the 1-3.00 mnPCE/1,000 range, 65.3% of the 2,327 published negative control values do, and 83.5% are < 3 mnPCE/1,000. The frequency with which an individual experimental mean value lies outside the 1.00 to 3.00 mnPCE/1,000 range differs among stocks and appears related to the mouse mean frequency. We suggest that the recommended range for historical mean frequency be extended slightly, to approximately 3.4 mnPCE/1,000, to accommodate some commonly used strains with overall mean negative control frequencies just above 3.00 mnPCE/1,000.(ABSTRACT TRUNCATED AT 400 WORDS)

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Mutagenicity of oxytetracycline

Cited by 11 publications

References 8 publications

Tetracycline tagging in coregonid embryos and larvae

Tetracycline tagging in coregonid embryos and larvae

5‐Hydroxytetracycline Hydrochloride 2058‐46‐0

Bone marrow micronucleus assay: A review of the mouse stocks used and their published mean spontaneous micronucleus frequencies

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