Mutagenicity of constituents identified in pulp and paper mill effluents using the Salmonella/mammalian-microsome assay

Nestmann, Earle R.; Lee, Ernie G-H.; Matula, T.I.; Douglas, George R.; Mueller, Josef

doi:10.1016/0165-1218(80)90067-1

Cited by 140 publications

(26 citation statements)

References 21 publications

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“…Many researchers reported that the growth of fish, shell, bacteria, etc. in river could be affected while the concentration of 1,1,2,2-TTCE in river water was higher than 1 µg/m 3 (Nestmann et al, 1980;Nestmann and Lee, 1983;Smith et al, 1991;Nichols et al, 1993). Although the concentration of 1,1,2,2-TTCE was up to 210 µg/m 3 in this study, further studies should be required to confirm whether its concentration in river water will affect the growth of fish, shell, bacteria, etc.…”

Section: Levels and Distribution Of Chlorinated Aliphatic Vocsmentioning

confidence: 97%

Chlorinated volatile organic compounds found near the water surface of heavily polluted rivers

Juang

Lee

Hsueh

2009

Int. J. Environ. Sci. Technol.

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ABSTRACT:The objectives of this study were to identify the chlorinated volatile organic compounds near the water surface of two heavily polluted rivers in the south of Taiwan and compare their concentration distributions. Air samples were collected seasonally at the upstream, midstream and downstream water surfaces of each river and the chlorinated volatile organic compounds were analyzed qualitatively and quantitatively by gas chromatography and electron capture detector. Totally, twelve kinds of chlorinated volatile organic compounds were found at the water surfaces of both rivers and many of them were reported to be carcinogenic or probably carcinogenic to human. The results showed that each chlorinated volatile organic compound had its own distribution pattern and no good correlation of chlorinated volatile organic compounds between both rivers was obtained. The chlorinated volatile organic compounds identified at the river water surface of Fong Shan Stream showed much higher concentration than those of Chuen-Tsen River. Several chlorinated volatile organic compounds, including chlorodibromomethane, hexachlorobutadiene, 1,1,2,2-tetrachloroethene and 1,2-dibromo-3-chloropropane were found with much higher concentration (mean concentrations of 124.5 µg/m 3 , 334.5 µg/ m 3 , 92.2 µg/m 3 , 268.4 µg/m 3 , respectively) at the water surface of Fong Shan Stream in some seasons (especially spring and summer, summer and winter, spring and winter, spring and summer, respectively) and they were reported to be possibly carcinogenic to human. Therefore, it may be concluded that the people living close to Fong Shan Stream possibly had higher health risks due to the release of volatile organic compounds from the heavily polluted river.

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Section: Levels and Distribution Of Chlorinated Aliphatic Vocsmentioning

confidence: 97%

Chlorinated volatile organic compounds found near the water surface of heavily polluted rivers

Juang

Lee

Hsueh

2009

Int. J. Environ. Sci. Technol.

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“…20 % angegeben (Mayer und Goin 1994). + (187 mM) Nestmann et al 1980Marnett et al 1985O'Donoghue et al 1988Zeiger et al 1992Müller et al 1993O'Donoghue et al 1988Zimmermann et al 1985Mayer und Goin 1987Mayer und Goin 1994O'Donoghue et al 1988O'Donoghue et al 1988Perocco et al 1983 Tab. …”

Section: In Vitrounclassified

2‐Butanon [MAK Value Documentation in German language, 1996]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 22. Lieferung, Ausgabe 1996 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Aufnahme Verteilung Metabolismus Ausscheidung Erfahrungen beim Menschen Einmalige Exposition Wiederholte Exposition Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Gentoxizität Kanzerogenität Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Sonstige Wirkungen Bewertung

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“…Results of these in vitro genotoxicity studies are shown in Table 3-5. The available data indicate that ethylbenzene is not mutagenic in bacteria (Dean et al 1985;Degirmenci et al 2000;Florin et al 1980;Kubo et al 2002;Nestmann et al 1980;NTP 1986NTP , 1999Zeiger et al 1992) or yeast cells (Dean et al 1985;Nestmann and Lee 1983) in the presence or absence of metabolic activation. Ethylbenzene was found to induce forward results also reported in NTP 1992NTP , 1999; this concentration was near the lethal concentration of 100 mg/L.…”

Section: Systemic Effectsmentioning

confidence: 99%

“…In vivo genotoxicity studies in laboratory animals did not cause significant alterations in micronuclei formation (Mohtashamipur et al 1985;NTP 1992NTP , 1999 or unscheduled DNA syntheseis (Clay 2001). Data are available regarding the genotoxic potential of ethylbenzene from in vitro assays in bacteria, yeast, and mammalian cell cultures (Dean et al 1985;Degirmenci et al 2000;Florin et al 1980;Kubo et al 2002;Nestmann and Lee 1983;Nestmann et al 1980;NTP 1986NTP , 1999Zeiger et al 1992). The results generally indicate that ethylbenzene is not mutagenic.…”

Section: Chronic-duration Exposure and Cancer The Database Of Chronimentioning

confidence: 99%

Toxicological Profile for Ethylbenzene

2002

ATSDR's Toxicological Profiles

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Mutagenicity of constituents identified in pulp and paper mill effluents using the Salmonella/mammalian-microsome assay

Cited by 140 publications

References 21 publications

Chlorinated volatile organic compounds found near the water surface of heavily polluted rivers

Chlorinated volatile organic compounds found near the water surface of heavily polluted rivers

2‐Butanon [MAK Value Documentation in German language, 1996]

Toxicological Profile for Ethylbenzene

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