Mutagenicity of Antineoplastic Drug Residues Treated in Health Care Waste Autoclave

Bassi, M.; Morettón, Juan

doi:10.1007/s00128-003-0145-7

Cited by 8 publications

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“…Genotoxic chemical emissions from anthropogenic activities into environmental compartments require genotoxicity assays for the assessment of the potential impact of these sources on the ecosystems (Rank 2003). For example, some drugs like cytostatic agents are genotoxic (Bassi and Moretton 2003).…”

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confidence: 99%

Biomonitoring Hospital Effluents by the Allium cepa L. Test

Bagatini

Vasconcelos

Laughinghouse

et al. 2009

Bull Environ Contam Toxicol

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Hospital effluents are serious problems in developing countries like Brazil, and when not treated adequately, can cause mutagenic effects on live organisms. Biomonitors, like Allium cepa L., which is one of the most used plant species when monitoring effluent genotoxicity, have been used to alert the world population about environmental contamination and genotoxic chemical emissions. The Allium cepa test was used to evaluate the genotoxicity of a hospital effluent in Santa Maria, Rio Grande do Sul State, Brazil. During the study, chromosomal disruptions, anaphasic bridges, and micronuclei during telophase were observed, indicating environmental toxicity risk.

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confidence: 99%

Biomonitoring Hospital Effluents by the Allium cepa L. Test

Bagatini

Vasconcelos

Laughinghouse

et al. 2009

Bull Environ Contam Toxicol

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“…Indeed, some of the substances found in wastewaters are genotoxic and are suspected to be a possible contributor to certain cancers observed in last decades (Jolibois & Guerbet, 2006). For example, some drugs like cytostatic agents are genotoxic (Bassi & Moretton, 2003).…”

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confidence: 99%

CYTOTOXIC AND GENOTOXIC ASSESSMENT OF SEWAGE TREATMENT PLANT AT SHER-I-KASHMIR INSTITUTE OF MEDICAL SCIENCES(SKIMS) SOURA, SRINAGAR BY USING Allium CepaTest

Hassan¹,

Ali²,

Qadri³

2020

JEBAS

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Cyto-genotoxicity of hospital effluents collected from sewage treatment plant of SKIMS, was investigated using USEPA recommended Allium cepa test. Heterogeneous samples of both untreated and treated effluents were collected from the STP twice a day for three months and designated as complex mixture. Before measuring the root length of the onion bulbs, A. cepa plants were exposed to 25%, 50% and 100% concentrations for both untreated and treated effluent samples in the dark for 72hrs. Significant results were observed in the root length evaluation and chromosomal aberration evaluation tests. Untreated effluent seems to be the most toxic on the root length of the A.cepa than treated samples. The lowest mean root length of onion bulbs was observed in untreated samples at 100% concentration which is found to be 0.61±0.28, 0.95±0.21 and 1.16± 0.43 cm for first, second and third day respectively. Untreated sample from STP of SKIMS at 100% concentration gave the lowest mitotic index (MI) value of 4.56±1.44 while as 50% and 25% concentration shows MI values of 16.32±2.09 and 27.08±6.07 respectively. Likewise, treated samples show mitotic index (MI) values of 18.2±4.65, 3.96±5.54 and 2.01±2.91 at 25%, 50% and 100%. The squash preparations from root tip cells of treated A. cepa bulbs revealed different types of chromosomal aberrations such as metaphase stickiness, chromosomal breaks, c-mitosis, anaphase bridges and anaphase stickiness, indicating environmental toxicity risk. The treated effluent samples were found to be less genotoxic and cytotoxic, thus inferring that genotoxicity is reduced after the treatment process and A. cepa test has proved to be an effective tool in monitoring hospital effluents before beingdischarged into the environment.

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2012

Destruction of Hazardous Chemicals in the Laboratory

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Mutagenicity of Antineoplastic Drug Residues Treated in Health Care Waste Autoclave

Cited by 8 publications

References 0 publications

Biomonitoring Hospital Effluents by the Allium cepa L. Test

Biomonitoring Hospital Effluents by the Allium cepa L. Test

CYTOTOXIC AND GENOTOXIC ASSESSMENT OF SEWAGE TREATMENT PLANT AT SHER-I-KASHMIR INSTITUTE OF MEDICAL SCIENCES(SKIMS) SOURA, SRINAGAR BY USING Allium CepaTest

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