Mutagenicity, carcinogenicity and teratogenicity of thallium compounds

Léonard, A.; Gerber, G. B.

doi:10.1016/s1383-5742(97)00022-7

Cited by 94 publications

(48 citation statements)

References 28 publications

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“…In the oceanic crust, this concentration drops to 0.013 mg kg -1 (15). Thallium is estimated to have a mean seawater concentration of 65 pmol kg -1 (13).…”

Section: Natural Sourcesmentioning

confidence: 99%

“…Naturally occurring minerals with higher thallium concentration include crooksite, found in Sweden and Brazil, lorandite (Greece and the USA), hutchinsonite (Switzerland), orabite (Brazil and the USA), and berzelianite (Germany) (15). Several of these thallium minerals contain 16 % to 60 % of thallium, but have no commercial importance as a source of this element.…”

Section: Natural Sourcesmentioning

confidence: 99%

“…After absorption thallium is distributed from blood to tissue (6). In humans, kidneys display the highest concentrations, followed, in a decreasing order, by the bones, stomach, intestines, spleen, liver, muscle, lung, and brain (15).…”

Section: Human Studiesmentioning

confidence: 99%

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Thallium Toxicity in Humans

Cvjetko

Pavlica

2010

Archives of Industrial Hygiene and Toxicology

162

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Thallium is a naturally occurring trace element, widely distributed in the earth's crust, but at very low concentrations. It does not have a known biological use and does not appear to be an essential element for life. It has been considered one of the most toxic heavy metals. Occasionally, there are reports on thallium poisoning as results of suicide or murder attempt or accident. The main threat to humans is through occupational exposure, environmental contamination, and accumulation in food, mainly in vegetables grown on contaminated soil. Increasing use in emerging new technologies and demanding high-tech industry constantly raise concern about exposure risk to all living organisms. Thallium is considered a cumulative poison that can cause adverse health effects and degenerative changes in many organs. The effects are the most severe in the nervous system. The exact mechanism of thallium toxicity still remains unknown, although impaired glutathione metabolism, oxidative stress, and disruption of potassium-regulated homeostasis may play a role. The lack of data about mutagenic, carcinogenic, or teratogenic effects of thallium compounds in humans calls for further research.

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“…In the oceanic crust, this concentration drops to 0.013 mg kg -1 (15). Thallium is estimated to have a mean seawater concentration of 65 pmol kg -1 (13).…”

Section: Natural Sourcesmentioning

confidence: 99%

Section: Natural Sourcesmentioning

confidence: 99%

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Thallium Toxicity in Humans

Cvjetko

Pavlica

2010

Archives of Industrial Hygiene and Toxicology

162

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“…Thallium is excreted in breast milk and can cross the placental barrier [2]. Despite fetal complications ranging from severe toxicity and permanent deficit to normal development, the only consistent effect was increased risk of prematurity and low birth weight [3].…”

Section: Introductionmentioning

confidence: 99%

Acute Thallium Poisoning: Series of Ten Cases

et al. 2011

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“…The most pronounced toxic effect of the Tl ion is related to the similarity of Tl(I) to the potassium ion, due to their similar chemical structure and properties. Monovalent Tl disrupts Kcontrolled activity of enzymes and membrane processes such as the mitochondrial respiratory chain, and also stabilization of ribosomes (Le´onard and Gerber, 1997;Arzate and Santamaria, 1998;Peter and Viraraghavan, 2005 Ent et al, 2013). These are all terrestrial species originating from southern France.…”

Section: Introductionmentioning

confidence: 99%

Diversity of algae in a thallium and other heavy metals-polluted environment

Płachno

Wołowski

Augustynowicz

et al. 2015

Ann. Limnol. - Int. J. Lim.

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-Thallium (Tl) compounds are extremely toxic to living organisms, including algae, but there is a dearth of basic information regarding the mechanisms of action of Tl in the environment and its effects on algae in natural conditions. This study examined algal diversity in an environment highly polluted by Tl. Graniczna Woda stream is contaminated by Tl and other heavy metal compounds (Cd, Pb and Zn). There we found 66 algae taxa representing five phyla, among which euglenophytes prevailed. We found that euglenophytes, including Phacus species, can survive and can show high species diversity in the presence of high Tl concentrations. The fact that these small organisms covered only by a pellicle are able to thrive in such inhospitable habitat, shows a great plasticity of these organisms. It is unclear whether the algae of Graniczna Woda stream have a broad tolerance to harmful conditions or rather represent new varieties/clones that evolved in metal-contaminated waters and are adapted to this environment.

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Mutagenicity, carcinogenicity and teratogenicity of thallium compounds

Cited by 94 publications

References 28 publications

Thallium Toxicity in Humans

Thallium Toxicity in Humans

Acute Thallium Poisoning: Series of Ten Cases

Diversity of algae in a thallium and other heavy metals-polluted environment

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