Mutagenicity and genotoxicity studies of aspartame

Otabe, Akira; Ohta, Fumio; Takumi, Asuka; Lynch, Barry

doi:10.1016/j.yrtph.2018.01.023

Cited by 21 publications

(7 citation statements)

References 22 publications

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“…Although the safety of use of aspartame has been assessed by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), the US Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA), among others, few studies have tested its genotoxic properties in vivo and in vitro [67][68][69][70][71][72][73][74]. Unfortunately, none of these studies were conducted according to GLP [74,75]. Despite the lack of pharmaceutical studies in the GMP system, publications state that aspartame is not genotoxic [68,71,72,75,76].…”

Section: Genotoxicitymentioning

confidence: 99%

“…Unfortunately, none of these studies were conducted according to GLP [74,75]. Despite the lack of pharmaceutical studies in the GMP system, publications state that aspartame is not genotoxic [68,71,72,75,76]. In addition, research techniques have developed over the years and current methods are more accurate and reliable [75].…”

Section: Genotoxicitymentioning

confidence: 99%

“…Formaldehyde may damage DNA by its ability to crosslink proteins with it, and as aspartame is an exogenous sources of formaldehyde, its consumption may hence induce genotoxicity [79,80]. However, GLP-based studies on the genotoxicity and mutagenicity of aspartame based on bacterial reverse mutation and in vivo murine micronucleus testing found aspartame to have neither genotoxic nor mutagenic effects [75]. Other genotoxicity and mutagenicity studies were performed by Najam et al with aspartamine alone and in combination with sitagliptin, which is an oral antidiabetic drug [81,82].…”

Section: Genotoxicitymentioning

confidence: 99%

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Aspartame—True or False? Narrative Review of Safety Analysis of General Use in Products

et al. 2021

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Aspartame is a sweetener introduced to replace the commonly used sucrose. It was discovered by James M. Schlatter in 1965. Being 180–200 times sweeter than sucrose, its intake was expected to reduce obesity rates in developing countries and help those struggling with diabetes. It is mainly used as a sweetener for soft drinks, confectionery, and medicines. Despite its widespread use, its safety remains controversial. This narrative review investigates the existing literature on the use of aspartame and its possible effects on the human body to refine current knowledge. Taking to account that aspartame is a widely used artificial sweetener, it seems appropriate to continue research on safety. Studies mentioned in this article have produced very interesting results overall, the current review highlights the social problem of providing visible and detailed information about the presence of aspartame in products. The studies involving the impact of aspartame on obesity, diabetes mellitus, children and fetus, autism, neurodegeneration, phenylketonuria, allergies and skin problems, its cancer properties and its genotoxicity were analyzed. Further research should be conducted to ensure clear information about the impact of aspartame on health.

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Section: Genotoxicitymentioning

confidence: 99%

Section: Genotoxicitymentioning

confidence: 99%

Section: Genotoxicitymentioning

confidence: 99%

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Aspartame—True or False? Narrative Review of Safety Analysis of General Use in Products

et al. 2021

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“…It was evaluated by Ames assay and in vivo micronucleus assay. As a result, no genotoxic or mutagenic potential was observed in either test (Otabe et al, 2019). The genotoxic effects of ascorbic acid, benzoic acid, citric acid and sorbic acid in human peripheral blood lymphocytes were investigated using in vitro micronucleus assay.…”

Section: Some Of the Genotoxicity Studies With Food Additivesmentioning

confidence: 99%

Food Additives and Genotoxicity

Altunkaynak

Yilmaz

2021

International Journal of Science Letters

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In today's changing conditions, there has been an increase in the consumption of ready-made food with the change in eating habits. Moreover, parallel to the increase in ready-made food production, there has been an increase in the food additives used. The dose amounts of food additives are determined as a result of experimental analyses. However, some additives show long-term toxic effects on the human body in genotoxicity tests. In this review, definition of substances, purposes of usage, classification, genotoxicity, definitions of tests and publications of genotoxicity studies in food additives were discussed. The search was conducted in peer-reviewed journals using Science-Direct, Web of Science and Google Scholar. In this study, genotoxicity studies conducted with food additives between 2015-2021 were complied. For this purpose, the keywords ''food additive'', ''genotoxicity'' were used together and research articles were included in this study.

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“…En el ensayo de variaciones en las frecuencias de células micronucleadas (MNs) para evaluar el potencial genotóxico, donde se comparan las frecuencias de micronúcleos en las muestras tratadas con las testigo y se evalúan su significancia. También en las muestras obtenidas se evalúa el efecto citotóxico mediante las comparaciones de los ratio entre los eritrocitos jóvenes y adultos observadas o por el porcentaje de eritrocitos jóvenes en el total de eritrocitos [18,19].…”

Section: Introductionunclassified

Evaluación in vivo del efecto genotóxico y citotóxico de los extractos acuosos de dos variedades mutantes de Hibiscus sabdariffa L.

Corrales

Branda

Cepero

et al. 2021

ACI

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El Hibiscus sabdariffa (flor de Jamaica, grosella o rosella), conocida además como rosa piola en Paraguay, tiene uso medicinal en gran parte del mundo; en Paraguay se utiliza como antiescorbútico, mientras que en otros países se utiliza como antihipertensivo, antiespasmódico o como agente antimicrobiano, entre otros usos. La radiación gamma es utilizada para la obtención de variedades mejoradas de diferentes especies vegetales; las variedades de grosella ANA DELIA y DOGO fueron obtenidas por irradiación Gamma como parte del programa de mejoramiento genético del INCA. El objetivo de este trabajo fue evaluar el efecto genotóxico y citotóxico del extracto acuoso de cálices de ambas variedades de grosella sobre células de médula ósea de ratones tratados con 3 concentraciones de cada extracto, vía oral, durante 15 días. El efecto genotóxico fue evaluado mediante la aplicación del ensayo de Micronúcleos. El efecto citotóxico se verifica por el índice obtenido entre la frecuencia de Eritrocitos Policromáticos (eritrocitos jóvenes) y la frecuencia de Eritrocitos Normocromáticos (eritrocitos adultos). Los resultados mostraron que los extractos evaluados, en las concentraciones utilizadas, no tienen un efecto genotóxico o citotóxico en células de médula ósea de ratones tratados por 15 días con los mismos.

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Mutagenicity and genotoxicity studies of aspartame

Cited by 21 publications

References 22 publications

Aspartame—True or False? Narrative Review of Safety Analysis of General Use in Products

Aspartame—True or False? Narrative Review of Safety Analysis of General Use in Products

Food Additives and Genotoxicity

Evaluación in vivo del efecto genotóxico y citotóxico de los extractos acuosos de dos variedades mutantes de Hibiscus sabdariffa L.

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