Mutagenic efficiency of organophosphorus insecticides used in combined treatments.

Degraeve, N.; Chollet, Marie-Christine; Moutschen, J.

doi:10.1289/ehp.8560395

Cited by 14 publications

(1 citation statement)

References 6 publications

(8 reference statements)

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“…However, the rate of reabsorption was higher in the group receiving cyclophosphamide in association to β-glucan at the highest concentration. Analysis of the rate of post-implantation losses is also known as the dominant lethal assay (Degraeve et al , 1985; Morrissey et al , 1990). …”

Section: Discussionmentioning

confidence: 99%

Effects of β-glucan polysaccharide revealed by the dominant lethal assay and micronucleus assays, and reproductive performance of male mice exposed to cyclophosphamide

et al. 2014

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β-glucan is a well-known polysaccharide for its chemopreventive effect. This study aimed to evaluate the chemopreventive ability of β-glucan in somatic and germ cells through the dominant lethal and micronucleus assays, and its influence on the reproductive performance of male mice exposed to cyclophosphamide. The results indicate that β-glucan is capable of preventing changes in DNA in both germ cells and somatic ones. Changes in germ cells were evaluated by the dominant lethal assay and showed damage reduction percentages of 46.46% and 43.79% for the doses of 100 and 150 mg/kg. For the somatic changes, evaluated by micronucleus assay in peripheral blood cells in the first week of treatment, damage reduction percentages from 80.63–116.32% were found. In the fifth and sixth weeks, the percentage ranged from 10.20–52.54% and −0.95–62.35%, respectively. Besides the chemopreventive efficiency it appears that the β-glucan, when combined with cyclophosphamide, is able to improve the reproductive performance of males verified by the significant reduction in rates of post-implantation losses and reabsorption in the mating of nulliparous females with males treated with cyclophosphamide.

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Section: Discussionmentioning

confidence: 99%

Effects of β-glucan polysaccharide revealed by the dominant lethal assay and micronucleus assays, and reproductive performance of male mice exposed to cyclophosphamide

et al. 2014

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Chromosome aberration and sister chromatid exchange in workers of the iron and steel factory of İskenderun, Turkey

Topaktaş

Rencüzoğulları

İla

et al. 2002

Teratog Carcinog Mutagen

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The aim of this study was to investigate, by using chromosome aberration (CA) and sister chromatid exchange (SCE) tests, whether or not the workers employed in the Iskenderun (Turkey) iron and steel factory have any genotoxic risk. The CA and the SCE were investigated in 48 males employed in a coke ovens unit and 8 males employed in a product side unit of the factory and in control groups. The frequency of CA was higher while the frequency of the SCE was not in all the smoker-nonsmoker workers than in smoker-nonsmoker control groups. In addition, there was no significant decrease in the RI, while the MI was significantly lower than in the controls. .

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Assessment of the genotoxic effects of organophosphorus insecticides phorate and trichlorfon in human lymphocytes

Timoroğlu

Yüzbaşıoğlu

Ünal

et al. 2012

Environmental Toxicology

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In vitro genotoxic effects of organophosphorus insecticides Phorate (PHR) and Trichlorfon (TCF) were investigated using four genotoxicity endpoints. Different concentration ranges between 0.25-2.00 μg mL(-1) of PHR and 2.34-37.50 μg mL(-1) of TCF were applied to lymphocytes. PHR and TCF significantly increased the frequency of chromosomal aberrations (except 2.34 μg mL(-1) for TCF) and sister chromatid exchanges at all treatment times and concentrations. Most of the used concentrations induced a significant increase in the frequency of micronuclei. Furthermore, PHR and TCF significantly decreased the mitotic index at the higher concentrations after 24- and 48-h treatments. In the comet assay, PHR and TCF significantly increased the comet tail at all concentrations. However, the comet tail intensity was significantly increased at only the highest concentration of PHR and at all concentrations of TCF. According to these results, PHR and TCF possess clastogenic, mutagenic, and DNA damaging effects in human lymphocytes in vitro.

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Mutagenic efficiency of organophosphorus insecticides used in combined treatments.

Cited by 14 publications

References 6 publications

Effects of β-glucan polysaccharide revealed by the dominant lethal assay and micronucleus assays, and reproductive performance of male mice exposed to cyclophosphamide

Effects of β-glucan polysaccharide revealed by the dominant lethal assay and micronucleus assays, and reproductive performance of male mice exposed to cyclophosphamide

Chromosome aberration and sister chromatid exchange in workers of the iron and steel factory of İskenderun, Turkey

Assessment of the genotoxic effects of organophosphorus insecticides phorate and trichlorfon in human lymphocytes

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