Mutagenic Effects of Ionizing Radiation on Immature Rat Oocytes

Asakawa, Jun‐ichi; Kamiguchi, Yujiroh; Kamiya, Kenji; Nakamura, Nori

doi:10.1667/rr13776.1

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…For example, researchers have observed maternally derived germline alterations in microsatellite DNA after a radiation accident in Brazil 14 . Overall, there remains very limited evidence in animal and human studies suggesting maternal exposure to radiation causes germline alterations 18 . Prior studies have also shown maternal smoking and occupational exposures to hazardous agents during pregnancy as potential risk factors for the development of unilateral rather than bilateral retinoblastoma 3,8 .…”

Section: Discussionmentioning

confidence: 99%

Medical radiation exposure and risk of sporadic retinoblastoma

Shakeel

Pace

Chambers

et al. 2020

Pediatric Blood & Cancer

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Background: While there is evidence that parental exposure to medical radiation is associated with increased risk of sporadic bilateral retinoblastoma in offspring, this association has not been confirmed. Additionally, the relationship between paternal and maternal exposures and sporadic unilateral retinoblastoma has not been fully investigated. Procedure: Data were obtained from two large multicenter case-control studies of retinoblastoma. For the paternal analyses, 268 bilateral cases, 155 unilateral cases, and 358 controls were included. For the maternal analyses, 298 bilateral cases, 184 unilateral cases, and 404 controls were included. Logistical regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) to evaluate the associations between parental exposures to medical radiation and sporadic retinoblastoma, while adjusting for potential confounders. Results: Paternal exposure to medical radiation was not significantly associated with sporadic bilateral retinoblastoma in offspring. However, increasing paternal exposure to gonadal radiation was associated with increased risk of unilateral retinoblastoma (P-trend = .03). Maternal history of upper and lower gastrointestinal (GI) series was associated with bilateral retinoblastoma (OR = 1.9, 95% CI: 1.1-3.2 and OR = 6.9, 95% CI: 2.9-16.4, respectively). However, there was no association between maternal exposure to medical radiation and unilateral retinoblastoma in offspring. Conclusion: Our investigation adds to the evidence that medical radiation exposure in fathers as well as mothers prior to pregnancy may increase the risk of germline alterations leading to the development of retinoblastoma in their offspring. However, our findings could point to a more complex etiological framework for this important pediatric malignancy.

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Section: Discussionmentioning

confidence: 99%

Medical radiation exposure and risk of sporadic retinoblastoma

Shakeel

Pace

Chambers

et al. 2020

Pediatric Blood & Cancer

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“…Автор также отмечает, что последствия облучения обоих предков проявляются у потомства не менее чем в двух поколениях, при этом летальные эффекты у потомства первого поколения реализуются преимущественно в эмбриогенезе, а во втором поколениив раннем постнатальном онтогенезе. Значение стадий гаметогенеза для генетической радиопоражаемости подтверждают J. Asakawa et al [24] в скрининге 2,26 миллио-нов фрагментов ДНК из потомства (F1) самок крыс, подвергнутых облучению в 2,5 Гр в ранней стадии овогенеза. Анализ микросателлитных мутаций и делеций позволил авторам сделать вывод, что незрелые ооциты менее чувствительны к индукции мутации, чем зрелые ооциты.…”

Section: экспериментальные исследования наследуемых эффектовunclassified

Heritable effects in offspring associated with harmful exposure to parents (Literature review)

Sosnina

Sokolnikov

2019

Radiac. gig. (2008)

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A review of literature data regarding the heritable effects in offspring due to parents’ contact with mutagenic risk factors is presented. Studies on various factors of adverse effects on the hereditary apparatus, including chemical, infectious, physical and biological, are considered. The influence of smoking and parents’ age on the occurrence of de novo mutations is shown. Particular attention is paid to the review of publications on the role of the radiation factor in the genesis of hereditary disorders in offspring. Development stages of radiation genetics, the evolution of conception about radiation harm are described. The results of experimental, cytogenetic, molecular genetic, epidemiological studies analyzing the contribution of parental exposure to inherited pathology in progeny are presented. Special attention is paid to the “untargeted” effects of radiation and studies which prove the possibility of transgenerative transmission of genome instability are presented. The special contribution of studies on the cohort of atomic bomb victims offspring in Hiroshima and Nagasaki, which is considered as the main scientific platform for radiation risk assessment, is noted. There are articles about the offspring of persons who underwent therapeutic exposure, who had professional contact with ionizing radiation, who were exposed to radiation as a result of the Chernobyl accident, nuclear weapons tests at the Semipalatinsk test site, chronic radiation in the radioactively contaminated territory of the Techa river, areas with naturally increased radioactivity. As a result, it was noted that, despite numerous confirmations of radiation-induced effects in offspring obtained within experimental and molecular genetic studies, the results of epidemiological studies remain controversial. Possible reasons for these discrepancies are considered. An idea of views evolution regarding heritable effects in the international system of radiation safety is given. A new approach of the International Commission on Radiological Protection to heritable effects is described; the dynamics of tissue weighting factors for gonads in the assessment of effective radiation dose is shown. Methods for evaluating heritable effects are presented: the direct method and the doubling dose method. Attention is focused on the uncertainties that remain in the modern assessment of radiation genetic damage. The necessity of further study of radiation-induced heritable effects is shown. The perspective directions of studying the heritable effects are considered. The possibility of the analysis of heritable effects is described using the example of a cohort of the Mayak Production Association workers’ offspring – the country’s first nuclear industry enterprise.

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“…In vitro , both spermatogonia and oogonia are highly sensitive to ionizing radiation exposure [ 6 , 7 ], and there is strong evidence that environmental, physical, and chemical stressors including ionizing radiation can adversely impact male fertility [ 8 ]. Early epidemiological evidence suggested that as little as 0.11 Gy was sufficient to significantly suppress human spermatogenesis [ 9 ], with in vitro evidence that a dose as low as 10 mGy can arrest spermatogenesis [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Parental chest computerized tomography examination before IVF/ICSI has no impact on pregnancy and neonatal outcomes: a cohort study of 2680 fresh transfer cycles

Wang

Zhao

et al. 2022

BMC Pregnancy Childbirth

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Background Some concern has been expressed regarding the negative effects of low-level ionizing radiation exposure in the context of radiological evaluation prior to IVF/ICSI treatment, but the available evidence is limited and conflicting. The aim of this study is to evaluate pregnancy and neonatal outcomes of couples who did chest computed tomography (CT) prior to IVF/ICSI. Methods This was a retrospective cohort study of 2680 IVF/ICSI fresh embryo transfer cycles conducted from January 2019 – August 2020. Fertility outcomes were compared between couples that had or had not undergone CT examination within 3 months prior to the date of oocyte retrieval and sperm collection. Miscarriage was the primary study outcome, while secondary outcomes included the number of oocytes collected, oocyte maturation, normal fertilization, number of good quality cleavage stage embryos, blastocyst formation, implantation, clinical pregnancy, ectopic pregnancy, live birth, multiple birth, Cesarean section rates, gestational weeks, maternal obstetric complications, birth weight, newborn sex ratio, and birth defect incidence. Propensity score matching was used to control for potential confounding variables. Results Of the 2680 cycles included in this study, couples underwent CT examination in 731 cycles. After 1:1 propensity score matching, 670 cycles were included in each group. When comparing demographic and fertility-related variables between groups that had and had not undergone CT examination after propensity score matching, we detected no significant differences in miscarriage rates (16.99% vs. 15.77%, OR = 1.10, 95CI% = 0.74 to 1.68). Similarly, both groups exhibited comparable oocyte and embryonic development, implantation rates (41.99% vs. 40.42%, OR = 1.07, 95%CI = 0.87 to 1.31), clinical pregnancy rates (45.67% vs. 44.48%, OR = 1.05, 95%CI = 0.85 to 1.30), ectopic pregnancy rates (2.94% vs. 1.68%, OR = 1.78, 95%CI = 0.59 to 5.36), live birth rates (36.57% vs. 35.67%, OR = 1.04, 95%CI = 0.83 to 1.30), multiple birth rates, Cesarean section rates, gestational weeks, maternal obstetric complication rates, and neonatal outcomes. Conclusions Chest CT examination before IVF/ICSI has no impact on pregnancy and neonatal outcomes associated with fresh embryo transfer. Trial registration Not applicable.

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Mutagenic Effects of Ionizing Radiation on Immature Rat Oocytes

Cited by 6 publications

References 9 publications

Medical radiation exposure and risk of sporadic retinoblastoma

Medical radiation exposure and risk of sporadic retinoblastoma

Heritable effects in offspring associated with harmful exposure to parents (Literature review)

Parental chest computerized tomography examination before IVF/ICSI has no impact on pregnancy and neonatal outcomes: a cohort study of 2680 fresh transfer cycles

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