Mutagenic effects of carbosulfan, a carbamate pesticide

Giri, Sarbani; Giri, Anirudha; Sharma, G.D.; Prasad, Surendra

doi:10.1016/s1383-5718(02)00114-6

Cited by 57 publications

(26 citation statements)

References 30 publications

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“…Hemavathi and Rahiman (38) stated that the commonly used dithiocarbamate fungicides ziram, thiram, and dithane M-45 induced a significant increase in the frequency of abnormal sperm at all tested doses. Giri et al (39) have observed that the highest concentration of carbosulfan induced a >7-fold increase in the frequency of abnormal sperm. Ma et al (40) found that the total sperm morphological abnormality was significantly higher in carbon disulphide-exposed workers.…”

Section: Discussionmentioning

confidence: 99%

Abnormal sperm morphology in mouse germ cells after short-term exposures to acetamiprid, propineb, and their mixture

Rasgele

2014

Archives of Industrial Hygiene and Toxicology

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Pesticides are one of the most potent environmental contaminants, which accumulate in biotic and abiotic components of ecosystems. Acetamiprid (Acm), a neonicotinoid insecticide, and Propineb (Pro), a dithiocarbamate fungicide, are widely used to control sucking insects and fungal infections on crops, respectively. The present study was undertaken to investigate the genotoxic effects of these compounds, individually and in mixtures, in mouse germ cells by using the sperm morphology assay. Mice were injected intraperitoneally with 0.625, 1.25, and 2.50 µg mL -1 of Acm, 12.5, 25, and 50 µg mL -1 of Pro, and their mixture at the same concentrations over 24 and 48 h. Acm did not significantly increase the percentage of abnormal sperm at any concentration. The frequency of abnormal sperm significantly increased after 24 and 48 h of exposure to 50 µg mL -1 of Pro. The mixtures of 2.50 µg mL -1 of Acm and 50 µg mL -1 of Pro induced sperm abnormalities antagonistically both after 24 and 48 h of exposure. Results suggest that Acm was non-genotoxic for mouse germ cells, while Pro may have been a germ cell mutagen due to the observed increase in the frequency of sperm abnormalities. However, to gain better insight into the mutagenicity and DNA damaging potential of both of these pesticides, further studies at molecular level should be done.

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Section: Discussionmentioning

confidence: 99%

Abnormal sperm morphology in mouse germ cells after short-term exposures to acetamiprid, propineb, and their mixture

Rasgele

2014

Archives of Industrial Hygiene and Toxicology

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“…Among them there are compounds of very high toxicity (19)(20)(21). In humans, they affect oxidative processes, nucleic acids and the haematosis function.…”

Section: Resultsmentioning

confidence: 99%

A bioluminescent signal system: detection of chemical toxicants in water

Vetrova

Esimbekova

Remmel³

et al. 2007

Luminescence

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Prototype technologies of a bioluminescent signal system (BSS) based on the luminous bacterium Photobacterium phosphoreum and three enzymatic bioluminescence systems have been proposed for detecting and signalling the presence of toxicants in water systems. A number of pesticides, mostly known as poisonous substances, similar in their structures and physicochemical properties, have been taken as model compounds of chemical agents. The effect of toxicants (organophosphates, derivatives of dithiocarbamide acid, and pyrethroid preparations) on the bioluminescence of the four systems has been analysed. EC(50) and EC(80) have been determined and compared to the maximum permissible concentration for each of the analysed substances. The triple-enzyme systems with ADH and trypsin have been shown to be more sensitive to organophosphorous compounds (0.13-11 mg/L), while the triple-enzyme system with trypsin is highly sensitive to lipotropic poison, a derivative of dithiocarbamine acid (0.03 mg/L). Sensitivities of the triple-enzyme systems to pyrethroid preparations are similar to those of luminous bacteria (0.9-5 mg/L). The results can be used to construct an alarm-test bioluminescence system for detecting chemical toxicants, based on intact bacteria or enzyme systems.

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“…Developments of chromosomal aberrations, micronuclei and sperm abnormalities in response to chemical exposure are effective cytogenetic biomarkers useful to identify mutagenic agents (Giri et al, 2002;Garcia-Sagredo, 2008). Bone marrow cells are susceptible to oxidative damage and sensitive to clastogenic chemicals so, it has been commonly used for screening of mutagenicity and/or antimutagenicity property of chemicals (Umegaki et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Ascorbic Acid (Vitamin C)-Mediated Protection on Mutagenic Potentials of Cisplatin in Mice Bearing Ascites Dalton ’s Lymphoma

Amenla¹,

Prasad²

2016

Research J. of Mutagenesis

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Cisplatin is a potent anticancer drug which has been in use against a variety of cancers for a long time. The present study was carried out to assess the protective ability of ascorbic acid on cisplatin-induced mutagenic effects in tumor-bearing mice. The increase in the frequency of chromosomal aberrations, micronuclei and sperm abnormality were studied as markers of mutagenicity. Indicators of oxidative stress relatives like lipid peroxidation, reduced glutathione and the activities of enzymes such as catalase, glutathione-S-transferase and glutathione reductase were also studied to understand the possible mechanism(s) underlying this amelioration. Pre-treatment with ascorbic acid in combination group significantly reduced cisplatin-induced mutagenicity, markedly decreased lipid peroxidation along with increased level of glutathione and activities of antioxidant enzymes particularly in the liver of mice. The overall studies suggest that ascorbic acid with its antioxidant and free radical scavenging properties may play a part in its protective role in the abatement of cisplatin-induced mutagenesis and oxidative damage in the normal tissues of mice.

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Mutagenic effects of carbosulfan, a carbamate pesticide

Cited by 57 publications

References 30 publications

Abnormal sperm morphology in mouse germ cells after short-term exposures to acetamiprid, propineb, and their mixture

Abnormal sperm morphology in mouse germ cells after short-term exposures to acetamiprid, propineb, and their mixture

A bioluminescent signal system: detection of chemical toxicants in water

Ascorbic Acid (Vitamin C)-Mediated Protection on Mutagenic Potentials of Cisplatin in Mice Bearing Ascites Dalton ’s Lymphoma

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