Mutagenic and histopathological effects of hexavalent chromium in tadpoles of Lithobates catesbeianus (Shaw, 1802) (Anura, Ranidae)

Monteiro, José Augusto do Nascimento; Cunha, Lorena Araújo da; Costa, Mary Helen Pestana da; Reis, Herald Souza dos; Aguiar, Aliceane Carolina da Silva; Oliveira-Bahia, Verônica Regina Lobato de; Burbano, Rommel Rodrı́guez; Rocha, Carlos Alberto Machado da

doi:10.1016/j.ecoenv.2018.07.083

Cited by 26 publications

(17 citation statements)

References 39 publications

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“…Chromium plays a major role in various industrial applications; thus, high industrial pollution of the environment with this metal compound, especially its hexavalent form, is a significant problem (5,22). This study revealed the potential of A. nilotica leaves to abate K 2 Cr 2 O 7 induced hepato-and hematotoxicity in male and female experimental animals.…”

Section: Discussionmentioning

confidence: 77%

“…Hexavalent chromium [Cr (VI)] is one of the valence state chromium majorly exists in the environment. It is found on surface coatings and in water systems under alkaline pH and mild oxidizing conditions posing a major environmental health challenge (5). It easily permeates the cell membrane with the aid of the sulphate anion transport system present in the membrane and thereafter reduced to other lower oxidation states, leading to accumulation in various organs and triggering a multiplex of reactive oxygen species (ROS) and organ damage (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

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Potassium Dichromate-Induced Hepato- and Hematotoxicity in Rats: Nutritive Composition and Ameliorative Role of Acacia nilotica L. Leaf

Ejoh

Iheagwam

Olusola

2021

Jundishapur J Nat Pharm Prod

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Background: Chromium and its salts, as well as chromium-containing compounds, play a major role in numerous manufacturing processes and have been contraindicated in carcinogenic, toxic, and mutagenic conditions in people involved in these processes. Objectives: This study investigated the ameliorative role of Acacia nilotica aqueous leave extract (ANLA) on potassium dichromate-induced liver and blood toxicity in male and female rats. Phytochemical screening and nutrient composition of ANLA were also evaluated. Methods: Phytochemical and proximate analysis of ANLA were carried out. Twenty adult male and female rats each were divided into four groups (n = 10): (1) control; (2) potassium dichromate (PDC; 0.625 mg/kg body weight); (3) PDC co-treated with ANLA after seven days (650 mg/kg bwt); and (4) PDC co-treated with ANLA (650 mg/kg bwt) simultaneously for 21 days. Biomarkers of liver injury, lipid, and hematological imbalance were assessed. Tissue histology and toxicant retention were done. Results: Various plant secondary metabolites (flavonoids, terpenoids, tannins, phenols, saponins, cardiac glycosides, alkaloids, and anthraquinones) and nutrients (protein = 67.41 ± 2.44%; carbohydrate = 9.87 ± 1.87%; fiber = 10.01 ± 1.21%; mineral = 6.41 ± 1.08%; fat and oil = 6.63 ± 0.93%) were identified in the leave. Exposure to chromium significantly (P < 0.05) increased plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) with a concomitant decrease in the activity of these enzymes in the liver of both male and female rats. The exposure also altered protein, triglyceride, and cholesterol levels in the plasma and liver as well as hematological indices. Organ chromium retention and pathological changes were also observed. ANLA modulated these chromium-induced alterations in the rats. Conclusions: Based on the results, ANLA indicates ameliorative property against PDC-induced toxicity in rats. Thus it may be used to combat chromium poisoning. The nutritive potential of A. nilotica leaves may also be maximized.

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Section: Discussionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Potassium Dichromate-Induced Hepato- and Hematotoxicity in Rats: Nutritive Composition and Ameliorative Role of Acacia nilotica L. Leaf

Ejoh

Iheagwam

Olusola

2021

Jundishapur J Nat Pharm Prod

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“…Previous studies indicated that long-term exposure to hexavalent chromium can cause parenchymal organ injury such as gastrointestinal tract, liver, and kidney. Additionally, hexavalent chromium has also been shown to be associated with cancer, asthma and gut microbial dysbiosis ( Yang Q. et al, 2020 ; Monteiro et al, 2018 ; Shaw et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Seaweed polysaccharide relieves hexavalent chromium-induced gut microbial homeostasis

Z²,

Wang³

et al. 2023

Front. Microbiol.

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Heavy metals released in the environment pose a huge threat to soil and water quality, food safety and public health. Additionally, humans and other mammals may also be directly exposed to heavy metals or exposed to heavy metals through the food chain, which seriously threatens the health of animals and humans. Chromium, especially hexavalent chromium [Cr (VI)], as a common heavy metal, has been shown to cause serious environmental pollution as well as intestinal damage. Thus, increasing research is devoted to finding drugs to mitigate the negative health effects of hexavalent chromium exposure. Seaweed polysaccharides have been demonstrated to have many pharmacological effects, but whether it can alleviate gut microbial dysbiosis caused by hexavalent chromium exposure has not been well characterized. Here, we hypothesized that seaweed polysaccharides could alleviate hexavalent chromium exposure-induced poor health in mice. Mice in Cr and seaweed polysaccharide treatment group was compulsively receive K2Cr2O7. At the end of the experiment, all mice were euthanized, and colon contents were collected for DNA sequencing analysis. Results showed that seaweed polysaccharide administration can restore the gut microbial dysbiosis and the reduction of gut microbial diversity caused by hexavalent chromium exposure in mice. Hexavalent chromium exposure also caused significant changes in the gut microbial composition of mice, including an increase in some pathogenic bacteria and a decrease in beneficial bacteria. However, seaweed polysaccharides administration could ameliorate the composition of gut microbiota. In conclusion, this study showed that seaweed polysaccharides can restore the negative effects of hexavalent chromium exposure in mice, including gut microbial dysbiosis. Meanwhile, this research also lays the foundation for the application of seaweed polysaccharides.

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“…The latter is severely toxic to aquatic organisms (Mishra and Bharagava 2016). There is evidence that Cr (VI) exposure can result in malformations, growth inhibition, and histopathological alterations of amphibians (Gardner et al 2017; Monteiro et al 2018). Historically, Cr (VI) was released into aquatic environments through a variety of industrial activities, such as effluents discharged from textiles, leather tanning, metal finishing, chrome electroplating, and printing industries (Taju et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Metamorphosis, Thyroid Gland, and Skeletal Ossification Induced by Hexavalent Chromium in Bufo gargarizans Larvae

Wang

Yang

Chen

et al. 2021

Enviro Toxic and Chemistry

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Hexavalent chromium (Cr [VI]) is one of the major detrimental heavy metal pollutants. In the present study, Bufo gargarizans were exposed to 0, 52, 104, 208, and 416 μg/L Cr (VI) from Gosner stage 2 until metamorphosis; and growth, development, and histological characteristics of the thyroid gland and skeletal ossification were examined. The results demonstrated that the survival rate of larvae exposed to Cr (VI) was not different from that measured in animals from the control group. However, high levels of Cr (VI) (104, 208, and 416 μg/L) were associated with significantly delayed growth and development. The suppression of skeletal ossification was observed at high Cr (VI) levels. Besides, histological alterations of the thyroid gland, such as follicular cell hyperplasia, colloid depletion, and peripheral colloid vacuolation, were found in 52 to 416 μg/L Cr (VI) treatments. The results of the present study highlight reductions in growth and development as well as percent metamorphosis and skeletal ossification due to histological alteration of the thyroid gland during exposure to Cr (VI) in B. gargarizans larvae. The present investigation could provide a basis for understanding the detrimental effects of Cr (VI) in amphibian larvae. Environ Toxicol Chem 2021;40:2474–2483. © 2021 SETAC

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Mutagenic and histopathological effects of hexavalent chromium in tadpoles of Lithobates catesbeianus (Shaw, 1802) (Anura, Ranidae)

Cited by 26 publications

References 39 publications

Potassium Dichromate-Induced Hepato- and Hematotoxicity in Rats: Nutritive Composition and Ameliorative Role of Acacia nilotica L. Leaf

Potassium Dichromate-Induced Hepato- and Hematotoxicity in Rats: Nutritive Composition and Ameliorative Role of Acacia nilotica L. Leaf

Seaweed polysaccharide relieves hexavalent chromium-induced gut microbial homeostasis

Inhibition of Metamorphosis, Thyroid Gland, and Skeletal Ossification Induced by Hexavalent Chromium in Bufo gargarizans Larvae

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