Mutagenic and antimutagenic activities of Uncaria tomentosa and its extracts

Rizzi, R.; Re, Francesco Lo; Bianchi, Antonio; Feo, Vincenzo De; Simone, Francesco De; Bianchi, Livia; Stivala, Lucia Anna

doi:10.1016/0378-8741(93)90080-o

Cited by 64 publications

(40 citation statements)

References 9 publications

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“…In addition to the anti-in¯ammatory properties of cat's claw, its protective antimutagenic effects have also been demonstrated in vitro against photomutagenesis. 12 The extract contains a mixture of quinovic acid and glycosides as well as pentacyclic or tetracyclic of oxindole alkaloids such as pteropodine, isopteropodine, speciophylline, uncarine F, mitraphylline and isomitraphylline. 13,14 The purpose of this study was twofold: (i) to investigate whether the bark extract of cat's claw Uncaria tomentosa (Willd.)…”

Section: Introductionmentioning

confidence: 99%

Antiinflammatory actions of cat’s claw: the role of NF‐κB

Sandoval-Chacon¹,

Thompson²,

Zhang³

et al. 1998

Aliment Pharmacol Ther

112

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Background: Uncaria tomentosa is a vine commonly known as cat’s claw or ‘uña de gato’ (UG) and is used in traditional Peruvian medicine for the treatment of a wide range of health problems, particularly digestive complaints and arthritis. Purpose: The aim of this study was to determine the proposed anti‐inflammatory properties of cat’s claw. Specifically: (i) does a bark extract of cat’s claw protect against oxidant‐induced stress in vitro, and (ii) to determine if UG modifies transcriptionally regulated events. Methods: Cell death was determined in two cell lines, RAW 264.7 and HT29 in response to peroxynitrite (PN, 300 μM). Gene expression of inducible nitric oxide synthase (iNOS) in HT29 cells, direct effects on nitric oxide and peroxynitrite levels, and activation of NF‐κB in RAW 264.7 cells as influenced by UG were assessed. Chronic intestinal inflammation was induced in rats with indomethacin (7.5 mg/kg), with UG administered orally in the drinking water (5 mg/mL). Results: The administration of UG (100 μg/mL) attenuated (P < 0.05) peroxynitrite‐induced apoptosis in HT29 (epithelial) and RAW 264.7 cells (macrophage). Cat’s claw inhibited lipopolysaccharide‐induced iNOS gene expression, nitrite formation, cell death and inhibited the activation of NF‐κB. Cat’s claw markedly attenuated indomethacin‐enteritis as evident by reduced myeloperoxidase activity, morphometric damage and liver metallothionein expression. Conclusions: Cat’s claw protects cells against oxidative stress and negated the activation of NF‐κB. These studies provide a mechanistic evidence for the widely held belief that cat’s claw is an effective anti‐inflammatory agent.

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Section: Introductionmentioning

confidence: 99%

Antiinflammatory actions of cat’s claw: the role of NF‐κB

Sandoval-Chacon¹,

Thompson²,

Zhang³

et al. 1998

Aliment Pharmacol Ther

112

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“…It aims to combat free radicals with substances or natural elements, whether they be vitamins, minerals, or amino acids. (Hemingway and Phillipson 1974;Montenegro de Matta et al 1976;Wagner et al 1985;Aquino et al 1989Aquino et al , 1991Yépez et al 1991;Rizzi et al 1992). The two species native to Central and South America have been used as medicinal plants in the various countries where they occur (Balée 1994), but their local use has been described mostly for Peru.…”

Section: Notesmentioning

confidence: 99%

“…The principal compounds found in both species are alkaloids, which have properties such as immuno-stimulating (oxindoles), anti-inflammatory (quinovic acid), antimutagenic (alkaloids and polyphenols), and anti-oxidant (alkaloids and other compounds). The cat's claw compounds can also inhibit cellular mitosis, increase the formation of granulocytes and macrophages, suppress the implantation of tumorigenic cells, inhibit cellular proliferation, and increase phagocytosis by macrophages (Hemingway and Phillipson 1974;Montenegro de Matta et al 1976;Wagner et al 1985;Aquino et al 1989Aquino et al , 1991Yépez et al 1991;Rizzi et al 1992).…”

Section: Potentials and Perspective Ofmentioning

confidence: 99%

Forest products, livelihoods and conservation: case studies of non-timber forest product systems. volume 3 - Latin America

Alexiades¹,

Shanley²

2005

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“…The plant is widely studied due to its medicinal properties, ecological and economic value. [4][5][6][7][8][9] Both Uncaria tomentosa (Willdenow ex Roemer and Schultes) DC. and Uncaria guianensis (Aublet) Gmell., from the Rubiaceae family, have been used by indigenous healers of tropical South America for the treatment of uncountable diseases and affections.…”

Section: Introductionmentioning

confidence: 99%

Controlling concentration of bioactive components in cat's claw based products with a hybrid separation process

Calvo

Dévényi

Kószó

et al. 2017

The Journal of Supercritical Fluids

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Supercritical fluid extraction (SFE) with and without entrainer combined with organic solvent extraction was used for fractionation of bioactive natural products as alkaloids and antioxidants from cat's claw (Uncaria tomentosa (Willd.) DC.) bark. Extracts obtained from this plant have a number of beneficial effects, including anti-inflammatory or immune stimulator. The aim of this work was to obtain extracts of enriched and limited alkaloid concentrations, good antioxidants and tannin agents. The results demonstrated that a hybrid process involving SFE is a selective method to obtain an oxindole alkaloid rich fraction (186.0 ± 3.2 mg total pentacyclic oxindole alkaloids/g extract) and a product enriched in tannins (23.8 ± 1.9 % tannin content in extract) and antioxidants (IC50 = 5.88 ± 0.54 µg/ml extract).

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Mutagenic and antimutagenic activities of Uncaria tomentosa and its extracts

Cited by 64 publications

References 9 publications

Antiinflammatory actions of cat’s claw: the role of NF‐κB

Antiinflammatory actions of cat’s claw: the role of NF‐κB

Forest products, livelihoods and conservation: case studies of non-timber forest product systems. volume 3 - Latin America

Controlling concentration of bioactive components in cat's claw based products with a hybrid separation process

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