Mutagenic and antifertility activity of trimethylphosphate in Drosophila melanogaster

Dyer, K. F.; Hanna, Peter

doi:10.1016/0027-5107(72)90165-0

Cited by 11 publications

(5 citation statements)

References 4 publications

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“…approximately 10-11 days. The bimodal distribution was not detected in a previous study using smaller numbers of flies (Dyer and Hanna 1972). It appears that genetic variation within the male flies used in these tests accounts for the distribution observed (Hanna, unpublished data).…”

Section: Fertility Tests On Adult Flies Following Tmp Treatment Durinmentioning

confidence: 52%

“…However, the findings of Dyer and Hanna (1972) suggested that the mode of action of TMP might be rather different in rodents and D. melanogaster. This was due to the relatively longer time required for the attainment of fertility in D. melanogaster compared with rodents.…”

Section: Introductionmentioning

confidence: 94%

“…An experiment, which was an extension of a previous investigation (Dyer and Hanna 1972), was carried out to determine more fully a dose response to the sterilizing action of TMP. Groups of 10 pairs of flies were allowed to produce F, generations in bottles containing different concentrations of TMP in the food medium.…”

Section: Treatment With Trimethylphosphatementioning

confidence: 99%

“…A sterilizing effect of TMP is known in male mice, rats, rabbits and Drosophila (Jackson and Jones 1968;Epstein et al 1970;Dean and Thorpe 1972;Dyer and Hanna 1972;Harbison et al 1976). In another investigation in which mice were used a single' dose of 100 mg/kg did not produce a temporary sterile period (Lorke and Machemer 1975).…”

Section: Introductionmentioning

confidence: 99%

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Sterilizing Effects of Trimethylphosphate in Drosophila Melanogaster

Hanna¹

1980

Aust. Jnl. Of Bio. Sci.

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Trimethylphosphate (TMP) causes aspermia in D. melanogaster males. If larvae are allowed to develop on standard maize-meal medium containing 0·002 M TMP or greater, the eclosing adult males, when placed on uncontaminated medium, exhibit a period of temporary sterility. Between test groups the period of sterility is most variable at the doses of 0·002--0·004 M, but at 0·005 M or greater is approximately 11-12 days. Near-lethal doses of about 20 g/kg by abdominal injection produces a temporary sterility in adults, whereas oral doses up to 0·02 M are ineffective. Oogenesis in females is not affected by doses which cause temporary sterility in males.In adult male D. meianogaster, which were treated as larvae with 0·01 M TMP in the food medium, the basal region of testes and seminal vesicles do not contain spermatozoa. Cytological examinations of the spermatids reveal ultrastructural changes which are characteristic of those seen in X/O and sterile-mutant males; they contain incomplete axial fibre complexes, abnormal development of the mitochondrial derivatives, and nuclei which fail to elongate and condense.Evidence from cytological studies of larval testes suggests that the chemosterilizing effect of TMP is upon early primary spermatocytes. This is also supported by mating data.

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Section: Fertility Tests On Adult Flies Following Tmp Treatment Durinmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 94%

Section: Treatment With Trimethylphosphatementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sterilizing Effects of Trimethylphosphate in Drosophila Melanogaster

Hanna¹

1980

Aust. Jnl. Of Bio. Sci.

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“…It is mutagenic in 5. typhimurium tester strains with R factor plasmids (his Cl 17) and nonmutagenic in his G46, his D3052, TA1530, TA1535, TA1531, TA1532, and TA1534 (Hanna and Dyer, 1975;Purchase et al, 1978); mutagenic in £. coli WP2, WP2 uvrA, WP67, and WP12 and nonmutagenic in £ coli CM561 and CM571 (Hanna and Dyer, 1975); mutagenic in Neurospora and Drosophila (Dyer and Hanna, 1972); and induces chromosome breaks in cultured human lymphocytes (Soderman, 1972) and in laboratory animals (Connor, 1979). TMP produces dominant lethal effects at high doses (e.g., 1000 mg/kg) and sperm abnormalities in mice (Connor, 1979;Dean and Thorpe, 1972;Epstein et al, 1970;Farrow, 1975).…”

Section: Phosphoric Acid Estersmentioning

confidence: 98%

Potential carcinogenic and mutagenic industrial chemicals. I. Alkylating agents

Fishbein¹

1980

Journal of Toxicology and Environmental Health

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Trimethylphosphat [MAK Value Documentation in German language, 1983]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 9. Lieferung, Ausgabe 1983 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Metabolismus und Ausscheidung von TMP Erfahrungen beim Menschen Tierexperimentelle Befunde Zur Frage eines MAK‐Wertes

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Mutagenic and antifertility activity of trimethylphosphate in Drosophila melanogaster

Cited by 11 publications

References 4 publications

Sterilizing Effects of Trimethylphosphate in Drosophila Melanogaster

Sterilizing Effects of Trimethylphosphate in Drosophila Melanogaster

Potential carcinogenic and mutagenic industrial chemicals. I. Alkylating agents

Trimethylphosphat [MAK Value Documentation in German language, 1983]

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