Mutagenic Activity of Nitriloacetic Acid

Nitrilotriacetic acid (NTA)

“…1,4 NTA increases the solubilization of some poorly soluble metal complexes and thus enhances the intracellular availability of potentially mutagenic complexes. It enhanced the induction of sister chromatid exchanges in Chinese hamster cells by insoluble salts of some heavy metals, 53,59 and some insoluble salts of chromium(VI) are mutagenic in the Salmonella microsome assay only in the presence of NTA or NaOH. 60 NTA is not teratogenic when administered alone or in combination with heavy metals such as cadmium or mercury.…”