Mutagenic activity of airborne particulate matter in a petrochemical industrial area

Coronas, Mariana Vieira; Horn, Rubem Cesar; Ducatti, Adriana; Rocha, Jocelita Vaz; Vargas, Vera Maria Ferrão

doi:10.1016/j.mrgentox.2007.12.002

Cited by 33 publications

(16 citation statements)

References 19 publications

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“…Four monthly samplings were performed for each site. The filters were weighed and stabilized before and after samples (45% humidity) for the determination of particulate concentration, expressed in µg/m 3 units of sampled air [12][13][14]. At the end of the sampling, the filters were combined to form a pool sample.…”

Section: Sampling Sitesmentioning

confidence: 99%

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Seasonal variations in the level of mutagenicity: an assessment of respirable particulate matter in Rio de Janeiro, Brazil

Rainho¹,

Corrêa²,

Mazzei³

et al. 2014

WIT Transactions on Ecology and the Environment

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Respirable particles (PM2.5) can become associated with organic matter containing several compounds such as polycyclic aromatic hydrocarbons (PAHs). Many PAHs have been identified as cancer-inducing chemicals. The mutagenicity of airborne particles is generally associated with PAHs, but recent reviews show that PAHs may not be the predominant mutagens in atmospheric pollution, and that nitroaromatic compounds, aromatic amines and aromatic ketones, often found in moderately polar or highly polar organic fractions, are potent mutagens. Nitro-polycyclicaromatics (nitro-PAHs) are persistent environmental mutagens and can be found in airborne suspended particles from direct sources such as diesel and gasoline exhausts, or may be products of atmospheric reactions in the presence of NO 2 and NO 3 radicals. In the present work we compared PAH levels and mutagenicity using gas chromatography spectrometry and the Salmonella/microsome assay on organic extracts of PM2.5 for Salmonella typhimurium strain TA98. The samples were collected in two periods: (I) July to October 2010 and (II) November 2010 to May 2011 at three sites in Rio de Janeiro -(1) low urban traffic at the University campus; (2) heavy . Mutagenic frameshift responses in the absence of metabolic activation were detected at all the sites in periods I and II. In the presence of metabolic activation this response was observed for all three sites in period I, but only for site 3 in period II. Nitroarenes and dinitroarenes were detected at all three sites in period I. In period II, the presence of nitroarenes was also detected at all sites, but dinitroarenes were only detected at sites 2 and 3. The information generated in this study shows that different levels of PAHs and nitroderivatives, influenced by seasonal variations in climatic conditions, probably contribute to the detected airborne mutagenicity.

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Section: Sampling Sitesmentioning

confidence: 99%

“…Prior to bioassays, the organic extract was dried at 4°C and resuspended in 5 µl dimethyl sulfoxide (DMSO, CASRN. 67-68-5, Synth, Brazil, purity 99.9%) [12][13][14].…”

Section: Extraction Of Organic Compoundsmentioning

confidence: 99%

Seasonal variations in the level of mutagenicity: an assessment of respirable particulate matter in Rio de Janeiro, Brazil

Rainho¹,

Corrêa²,

Mazzei³

et al. 2014

WIT Transactions on Ecology and the Environment

View full text Add to dashboard Cite

show abstract

“…detection (Peluso et al, 2008), comet test (Ianistcki et al, 2009;Kawanishi et al, 2009), sister chromatids exchanges (SCE) and micronuclei (Kawanishi et al, 2009), identification of gene mutations in mice (Yauk et al, 2008) and Ames test (Coronas et al, 2008;Traversi et al, 2009). Peluso et at.…”

Section: Genotoxic Effects Of Atmospheric Pollutionmentioning

confidence: 99%

Use of the Micronucleus Test on Tradescantia (Trad-MCN) to Evaluate the Genotoxic Effects of Air Pollution

Meireles¹,

Cerqueira²

2011

Air Pollution - New Developments

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“…Most of the samples presented higher responses in assays in the absence of S9 mix metabolization. Studies with nitrosensitive strains performed by Coronas et al (2008), indicate a significant contribution of nitro and amino derivatives of PAHs to the total mutagenicity of suspended particulates (Apel et al, 2010). In fifty percent of the cases, the nitrosensitive strains were more sensitive for mononitrocompounds or for dinitrocompounds.…”

Section: Genetic Biomarkers Applied To Environmental Air Quality: Ecomentioning

confidence: 99%

Genetic Biomarkers Applied to Environmental Air Quality: Ecological and Human Health Aspects

Vargas¹,

Brito²,

Coronas³

2011

Air Quality Monitoring, Assessment and Management

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Mutagenic activity of airborne particulate matter in a petrochemical industrial area

Cited by 33 publications

References 19 publications

Seasonal variations in the level of mutagenicity: an assessment of respirable particulate matter in Rio de Janeiro, Brazil

Seasonal variations in the level of mutagenicity: an assessment of respirable particulate matter in Rio de Janeiro, Brazil

Use of the Micronucleus Test on Tradescantia (Trad-MCN) to Evaluate the Genotoxic Effects of Air Pollution

Genetic Biomarkers Applied to Environmental Air Quality: Ecological and Human Health Aspects

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