“…In addition, recent studies have shown that inherited polymorphisms or mutations of the mitochondrial genome may modulate the risk of developing cancer, including prostate, oral and colorectal cancers (18,(38)(39)(40)(41). Somatic mtDNA mutations have been described in various types of human cancers including bladder, brain, breast, colon, head and neck, lung, ovaries, prostate, thyroid, and breast cancers (20,21,31,33).…”