Mussel inspired ZIF8 microcarriers: a new approach for large-scale production of stem cells

Fardjahromi, Mahsa Asadniaye; Razmjou, Amir; Vesey, Graham; Ejeian, Fatemeh; Banerjee, Balarka; Mukhopadhyay, Subhas Chandra; Warkiani, Majid Ebrahimi

doi:10.1039/d0ra04090h

Cited by 14 publications

(7 citation statements)

References 61 publications

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“…This may indicate the ability to deliver growth factors that assist the regeneration of chondrocytes, such as TGF-β1, through similar methods. Another study by Fardjahromi et al (2020) has shown the ability to use polystyrene beads that are immobilized with PDA, polyethyleneimine, and ZIF-8 for culturing hADSCs [ 51 ]. This allows the stem cells to adhere and proliferate, which may ultimately be used as a source for differentiating into chondrocytes for cartilage regeneration.…”

Section: Factors To Consider When Designing An Ideal Composite For Oa...mentioning

confidence: 99%

Metal–Organic Frameworks (MOFs) and Their Composites as Emerging Biomaterials for Osteoarthritis Treatment

2023

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Metal-Organic Frameworks (MOFs) have emerged as a novel component in biomaterial formulations over the past 5 years. The bioactivity of MOFs in bone or cartilage tissue is mediated through the sustained delivery of metal ions, bioactive ligands, or drug molecules that are loaded into the porous MOF structures. Alternatively, bioactivity may also originate from structure-specific properties. The latter includes the availability and accessibility of open metal coordination sites for the catalytic conversion of biomolecules into active agents. This narrative highlight aims to inspire strategies to utilize MOFs for treating osteoarthritis (OA), with a special focus on augmenting hydrogel-based biomaterials with MOFs. The added value of MOFs in these hydrogel formulations is discussed, and the biological efficacy is compared to approaches applying classical injectable biomaterials for OA treatment. Possible future directions and pitfalls of these novel MOF–hydrogel composites are emphasized to assist future transition of MOFs into clinical applications.

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Section: Factors To Consider When Designing An Ideal Composite For Oa...mentioning

confidence: 99%

Metal–Organic Frameworks (MOFs) and Their Composites as Emerging Biomaterials for Osteoarthritis Treatment

2023

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“…The level of autocrine cell fate determination markers in the ZIF-8 modified polypropylene membrane was also raised. When compared to the tissue culture plate, osteogenic markers were clearly overexpressed in response to ZIF-8 layer biomechanical features ( Asadniaye Fardjahromi et al, 2020 ; Ejeian et al, 2020 ). The nanoscale ZIF-8 coating on porous titanium implants increases osteogenic-related gene expression and protein secretion, as well as extracellular matrix mineralization, osteoblastic activity, and bone regeneration ( Chen et al, 2017 ).…”

Section: Applications Of Zeolites In Bone Tissue Engineeringmentioning

confidence: 99%

Zeolites: A series of promising biomaterials in bone tissue engineering

Cai

Chen

et al. 2022

Front. Bioeng. Biotechnol.

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As an important worldwide medical issue, bone defect exhibits a variety of physical and psychological consequences on sufferers. Some features of clinical treatments including bone grafting and limb shortening are not satisfactory. Recently, bone tissue engineering has been considered as the most effective approach to dealing with the issue of bone deformities. Meanwhile, a variety of biomaterials have been rationally designed and created for the bone regeneration and tissue repairing. Among all these admirable biomaterials for bone remodeling, zeolite-based materials can serve as efficient scaffold candidates with excellent osteo-inductivity. In addition, the porous nature and high biocompatibility of zeolites endow them with the ability as ideal substrates for cell adhesion and proliferation. More importantly, zeolites are investigated as potential coating materials for implants because they have been proven to increase osteo-conductivity and aid in local elastic modeling. Last but not least, zeolites can also be used to treat bone disorders and act as dietary supplements during the practical applications. Accordingly, numerous benefits of zeolite prompt us to summarize their recent biomedical progress including but not limited to the distinguishing characteristics, broad classifications, as well as promising usages in bone tissue engineering.

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“…[12,13] However, most of the metal-based catalysts were heterogeneous catalysts, the catalytic activity of some of these decreases upon immobilization due to the reduction in accessibility of active sites. [14] Furthermore, these heterogeneous systems typically operate under harsh conditions, such as high temperature to achieve high yields. [15,16] Among numerous transition metal-based catalysts, the polyoxometalate catalysts have attracted wide attention due to their excellent catalytic activity [17,18] and easy adjustment of acid or redox properties.…”

Section: Introductionmentioning

confidence: 99%

Study on the epoxidation of chain olefins using biquaternary ammonium phosphotungstic acid phase transfer catalysts under no‐solvent condition

Zhang,

Ju,

Geng

et al. 2023

Chemistry A European J

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In this study, we have developed a novel catalyst synthesized by phosphotungstic acid and a gemini quaternary ammonium cation salt. This quaternary ammonium salt not only reduces the interfacial tension between olefins and hydrogen peroxide but also forms a notably stable structure with phosphotungstic acid. Dodecene was successfully epoxidized to epoxy dodecane with a selectivity of 82.9 %. The impact of initial conditions was systematically investigated such as molar ratio, temperature, reaction time, and catalyst dosage on the catalytic performance. Characterization of the catalyst morphology was performed by SEM, TEM and SAXS. Raman spectra, FT‐IR and XPS spectra were employed to perform the catalyst transformation during the epoxidation reaction. This catalytic mechanism study could provide the industrial application in the epoxidation of long‐chain olefins.

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Mussel inspired ZIF8 microcarriers: a new approach for large-scale production of stem cells

Abstract: Mussel inspired ZIF8 microcarriers with high surface area, biocompatibility, and nanoscale surface roughness are applied to enhance mesenchymal stem cell attachment and proliferation in 3D cell culture.

Cited by 14 publications

References 61 publications

Metal–Organic Frameworks (MOFs) and Their Composites as Emerging Biomaterials for Osteoarthritis Treatment

Metal–Organic Frameworks (MOFs) and Their Composites as Emerging Biomaterials for Osteoarthritis Treatment

Zeolites: A series of promising biomaterials in bone tissue engineering

Study on the epoxidation of chain olefins using biquaternary ammonium phosphotungstic acid phase transfer catalysts under no‐solvent condition

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