Mussel-inspired multifunctional hydrogel dressing with hemostasis, hypoglycemic, photothermal antibacterial properties on diabetic wounds

Abstract

To meticulously establish an efficient photothermal multifunctional hydrogel dressing is a prospective strategy for the treatment of diabetic chronic wounds.

Advanced polymer hydrogels that promote diabetic ulcer healing: mechanisms, classifications, and medical applications

“…Manganese dioxide nanoparticles were also added to accelerate the decomposition of hydrogen peroxide for the production of oxygen and promotion of angiogenesis, cell crawling and cell proliferation. In addition, PDA/AM/GOx/MnO2 exhibited excellent antibacterial properties (97.87% and 99.99% against E. coli and S. aureus, respectively under 808 nm NIR radiation, and complete removal of bacterial biofilms) [ 247 ]. Shi et al used hollow mesoporous silica nanoparticles (HMSNs) as nanocarriers to codeliver azithromycin (AZM) and GOx.…”

PVA-based bulk microneedles capable of high insulin loading and pH-triggered degradation for multi-responsive and sustained hypoglycemic therapy

“…Among them, soluble MNs have attracted significant interest due to their safe dissolution within skin tissues, facilitating insulin release and averting significant infection transmission. [9][10][11] The soluble microneedles developed currently are commonly associated with the inherent solubility of the polymer such as polyvinylpyrrolidone (PVP), 12,13 alginate (Alg), 14,15 hyaluronic acid (HA), 16,17 etc., which is not intelligently responsive to the changes in the surrounding environment. Therefore, such microneedles always cause random degradation and rapid release of insulin, which may contribute to hypoglycemia in mice.…”

“…Therefore, conventional "closed-loop" microneedles are typically composed of soluble polymers that are infused with "closed-loop" nanoparticles. 10,26,32 GOx exhibits the capability to consume oxygen and generate H 2 O 2 , thereby inducing a localized hypoxic environment. 33,34 Additionally, GOx serves as a catalyst for the oxidation of glucose to gluconic acid, leading to a localized decrease in pH.…”

Mechanical, robust and conductive eco-friendly self-assembling hydrogel: a novel material for electromagnetic shielding

“…The inclusion of PEG not only improves the mechanical strength of the PVA hydrogel but also imparts high deformability and enhanced thermal properties. 34 Moreover, the large molecular chains of PVA and PEG can electrostatically attract and physically entangle with the SA molecular chains, further enhancing the mechanical capacity of the hydrogel. 22,27,28 SA, PVA and other materials will degrade naturally under specific circumstances of microorganisms.…”

“…It is deemed as the top choice for producing eco-friendly polymer materials. 33,34 In recent years, the preparation of hydrogel-type electromagnetic shielding materials has required the incorporation of relevant functional fillers to endow them with electrical conductivity and electromagnetic shielding capabilities. 35,36 Among carbon nanomaterials, graphene and carbon nanotubes, including their components and composites, are the materials of choice for electromagnetic shielding due to their low density, high conductivity, and corrosion resistance.…”