Mussel-inspired copolymer-coated polypropylene mesh with anti-adhesion efficiency for abdominal wall defect repair

Hu, Wanjun; Lu, Sheng; Zhang, Zhihang; Long, Zhu; Wen, Yazhou; Zhang, Tianzhu; Ji, Zhenling

doi:10.1039/c8bm01198b

Cited by 43 publications

(37 citation statements)

References 54 publications

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“…Therefore, the decoration of PP mesh surface with different biofriendly materials can provide the required biocompatibility such as enhanced cell growth 4 and microbial resistance 5 without compromising its bulk properties 6–9 . As the application of metal nanoparticles in biological areas is limited, 10 composite approach 8,11 and copolymers 12 were used to address these issues. However, the developed materials are very complex in structure, and the production techniques are cumbersome.…”

Section: Introductionmentioning

confidence: 99%

Nanodiamond‐chitosan functionalized hernia mesh for biocompatibility and antimicrobial activity

Saha

Houshyar

Sarker

et al. 2021

J Biomedical Materials Res

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Polypropylene (PP) mesh is most commonly used for the treatment of hernia and pelvic floor construction. However, some of the patients have a few complications after surgery due to the rejection or infection of the implanted meshes. The poor biocompatibility of PP mesh, low wettability results in poor cell attachment/proliferation and restricts the loading of antibacterial agent, leading to a slow healing process and high risk of infection after surgery. Here in this study, a new technique has been employed to develop a novel antimicrobial and biocompatible PP mesh modified with bioactive chitosan and functionalized nanodiamond (FND) for infection inhibition and acceleration of the healing process. An oxygen plasma treatment PP mesh was used then chitosan was strongly attached to the surface of the PP fibers. Subsequently, FND as an antibacterial agent was loaded into the chitosan modified PP fiber to provide desired antibacterial functions. The meshes were characterised with XRD, FTIR, SEM, EDX, water contact angle, confocal, and optical microscopy. The modified PP mesh with chitosan and FND showed a significant increase in its hydrophilicity and L929 fibroblast cell attachment. Furthermore, the modified mesh exhibited great antibacterial efficiency against Escherichia coli. Therefore, the newly developed technique to modify PP mesh could be a promising technique to generate a biocompatible PP mesh to accelerate the healing process and reduce the risk of infection after surgery.

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Section: Introductionmentioning

confidence: 99%

Nanodiamond‐chitosan functionalized hernia mesh for biocompatibility and antimicrobial activity

Saha

Houshyar

Sarker

et al. 2021

J Biomedical Materials Res

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“…In order to avoid the development of abdominal adhesions normally associated with synthetic meshes, Hu et al used Mussel-inspired copolymer-coated polypropylene mesh to repair abdominal wall defects and achieved good anti-adhesion effect. 27 On the other hand, in order to overcome the issue of insufficient mechanical strength associated with biological meshes, Song et al seeded tenocyte on SIS and used it to repair abdominal wall defects. The results showed that this composite mesh had sufficient strength to prevent the formation of hernias.…”

Section: Discussionmentioning

confidence: 99%

Graphene Oxide Functionalized Double-Layered Patch with Anti-Adhesion Ability for Abdominal Wall Defects

Liu

Hou

Liu

et al. 2021

IJN

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Background Effective repair of full-thickness abdominal wall defects requires a patch with sufficient mechanical strength and anti-adhesion characteristics to avoid the formation of hernias and intra-abdominal complications such as intestinal obstruction and fistula. However, patches made from polymers or bio-derived materials may not meet these requirements and lack the bionic characteristics of the abdominal wall. Materials and Methods In this study, we report a consecutive electrospun method for preparing a double-layer structured nanofiber membrane (GO-PCL/CS-PCL) using polycaprolactone (PCL), graphene oxide (GO) and chitosan (CS). To expand the bio-functions (angiogenesis/reducing reactive oxygen species) of the patch (GO-PCL/NAC-CS-PCL), N-acetylcysteine (NAC) was loaded for the repair of full-thickness abdominal wall defects (2×1.5cm) in rat model. Results The double-layered patch (GO-PCL/NAC-CS-PCL) showed excellent mechanical strength and biocompatibility. After 2 months, rats treated with the patch exhibited the desired repair effect with no hernia formation, less adhesion (adhesion score: 1.50±0.50, P<0.001) and more collagen deposition (percentage of collagen deposition: 34.94%±3.31%, P<0.001). Conclusion The double-layered nanomembranes presented in this study have good anti-hernia and anti-adhesion effects, as well as improve the microenvironment in vivo. It, therefore, holds good prospects for the repair of abdominal wall defects and provides a promising key as a postoperative anti-adhesion agent.

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“…In addition to common symptoms such as abdominal pain, the intestinal adhesion causes intestinal obstruction or even death (Cai et al, 2018;Sisodia, Sahu, & Kumar, 2016). Strategies for preventing adhesion usually include minimally invasive surgical techniques, drugs, biomaterial-based methods or in combination, of which biomaterial is the most widely applied (Charboneau, Delaney, & Beilman, 2018;Hu et al, 2019;Li et al, 2017). Biomaterials, based on specific physical and chemical properties, can protect patients from developing intestinal adhesion (Li, Ren, & Zhang, 2018;Wu et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Platelet‐rich fibrin prevents postoperative intestinal adhesion

Jia

Guo

et al. 2020

J Biomedical Materials Res

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Platelet‐rich fibrin (PRF) was prepared from the blood of BALB/C inbred mice to explore potential effects on postoperative intestinal adhesion. A murine model of intestinal adhesion characterized by abdominal wall defect/and cecum damage was established by scraping caecum serosa and cutting peritoneum and muscles in the abdominal wall. The wound was covered with PRF (group A), sodium hyaluronate (group B), or left alone (blank control; group C). All animals were monitored for 28 days. The incidence of adhesion was 35.0, 66.7, and 73.7% in groups A, B, and C, respectively. The incidence of adhesion in group A was significantly lower than that in group C (p < .05). Histopathologically, severity of fibrosis and the number of fibroblasts or inflammatory cells in group A were lower than those in groups B and C (p < .05), whereas the number of mesothelial cells was higher (p = .001). Furthermore, the severity of fibrosis and number of fibroblasts or inflammatory cells were lower in low grade than those in high grade of adhesion (p < .05), whereas the number of mesothelial cells was higher (p < .05). Collectively, PRF applied to abdominal surgery may reduce the incidence of intestinal adhesion by promoting proliferation of mesothelial cells whereas inhibiting proliferation of fibroblasts and infiltration of inflammatory cells.

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Mussel-inspired copolymer-coated polypropylene mesh with anti-adhesion efficiency for abdominal wall defect repair

Abstract: Construction of anti-adhesive polypropylene meshes through the in situ copolymerization grafting of poly(ethylene glycol) methacrylate and dopamine methacrylamide.

Cited by 43 publications

References 54 publications

Nanodiamond‐chitosan functionalized hernia mesh for biocompatibility and antimicrobial activity

Nanodiamond‐chitosan functionalized hernia mesh for biocompatibility and antimicrobial activity

Graphene Oxide Functionalized Double-Layered Patch with Anti-Adhesion Ability for Abdominal Wall Defects

Platelet‐rich fibrin prevents postoperative intestinal adhesion

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