Mussel-inspired bioadhesives in healthcare: design parameters, current trends, and future perspectives

Pandey, Nikhil; Soto-Garcia, Luis; Liao, Jun; Zimmern, Philippe E.; Nguyen, Kytai T.; Hong, Yi

doi:10.1039/c9bm01848d

Cited by 94 publications

(61 citation statements)

References 101 publications

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“…Over the last 15 years, major efforts have been devoted to mimic various aspects of the mussel byssus chemistry and function ranging from synthetic wet adhesives, self-healing fibres to flexible coatings. These mussel-inspired materials are reviewed at length elsewhere [56][57][58][59][60] and are not the focus of the current review. Instead, we focus here on how existing and emerging material processing technologies, particularly those based on microfluidic drops, might be harnessed to more closely mimic the distilled principles of the byssus assembly process rather than the material itself.…”

Section: Bioinspired Materials Processingmentioning

confidence: 99%

From vesicles to materials: bioinspired strategies for fabricating hierarchically structured soft matter

Amstad

Harrington

2021

Phil. Trans. R. Soc. A.

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Certain organisms including species of mollusks, polychaetes, onychophorans and arthropods produce exceptional polymeric materials outside their bodies under ambient conditions using concentrated fluid protein precursors. While much is understood about the structure-function relationships that define the properties of such materials, comparatively less is understood about how such materials are fabricated and specifically, how their defining hierarchical structures are achieved via bottom-up assembly. Yet this information holds great potential for inspiring sustainable manufacture of advanced polymeric materials with controlled multi-scale structure. In the present perspective, we first examine recent work elucidating the formation of the tough adhesive fibres of the mussel byssus via secretion of vesicles filled with condensed liquid protein phases (coacervates and liquid crystals)—highlighting which design principles are relevant for bio-inspiration. In the second part of the perspective, we examine the potential of recent advances in drops and additive manufacturing as a bioinspired platform for mimicking such processes to produce hierarchically structured materials. This article is part of the theme issue ‘Bio-derived and bioinspired sustainable advanced materials for emerging technologies (part 1)’.

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Section: Bioinspired Materials Processingmentioning

confidence: 99%

From vesicles to materials: bioinspired strategies for fabricating hierarchically structured soft matter

Amstad

Harrington

2021

Phil. Trans. R. Soc. A.

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“…[29] This intriguing biological material prompts to pursue advanced multi-functional adhesive materials. [9,[30][31][32][33][34][35][36][37][38][39] Due to the high availability, biocompatibility, and good mechanical properties, [40,41] cellulose and cellulose derivatives have been widely used in various fields such as hydrogels, paper, aerogel, membranes, medicines, sorption agents, and coatings. [42][43][44][45][46][47][48][49][50] The hydroxyl groups on anhydroglucose units make cellulose suitable for a variety of physical or chemical modifications.…”

Section: Introductionmentioning

confidence: 99%

“…[ 29 ] This intriguing biological material prompts to pursue advanced multi‐functional adhesive materials. [ 9,30–39 ]…”

Section: Introductionmentioning

confidence: 99%

Biocompatible Catechol‐Functionalized Cellulose‐Based Adhesives with Strong Water Resistance

Tang

Bian

Lin

et al. 2021

Macro Materials & Eng

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Numerous traditional adhesives have good adhesion in dry environments. However, non-environmental-friendliness and poor water resistance largely limit their practical applications. To prepare biocompatible adhesives with strong water resistance and adhesion strength, in this paper, catechol-functionalized cellulose-based adhesive polymers are synthesized by grafting N-(3,4-dihydroxyphenethyl)methacrylamide and methyl methacrylate onto cellulose chain through atom transfer radical polymerization (ATRP). The successful synthesis of the catechol-functionalized cellulose-based adhesive polymers is confirmed by FTIR and 1 H NMR. The different characteristics of the adhesive polymers, such as thermal stability, swelling ratio, biocompatibility, and adhesion strength are investigated. Strong water resistance on various substrates is realized in underwater environment for the catechol-functionalized cellulose-based adhesive with addition of Fe 3+ . The adhesion strength and thermal stability are enhanced when the catechol content is increased. The adhesive with catechol content of 25.4% shows the adhesion strength of 0.45 MPa for iron substrate in underwater environment. In addition, the adhesive with addition of Fe 3+ exhibits excellent adhesion in dry environment, with maximum adhesion strength of 3.50 MPa for iron substrate. The cell culture test shows that the adhesive polymers have excellent biocompatibility. The biocompatible adhesives with strong water resistance have potential application in electronic, wood, and building fields.

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“…Several reviews on the recent progress of analytical applications of mussel‐inspired polymer materials have been reported 29,30 . Pandey et al 31 . reported bioadhesion and adhesives from an engineering standpoint, specifically the requirements of a good tissue glue, the relevance that DOPA and other catechols have in tissue adhesion, and current trends in mussel‐inspired bioadhesives.…”

Section: Introductionmentioning

confidence: 99%

Mussel‐inspired polymer materials derived from nonphytogenic and phytogenic catechol derivatives and their applications

Wang

Zhang

et al. 2021

Polymer International

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When it comes to underwater adhesion, mussel is the true expert that can firmly attach onto wet rocks under dynamic and turbulent environments. Catechol‐like 3,4‐dihydroxyphenylalanine and its biochemical interactions have been largely implicated in mussels' strong adhesion to various substrates. We successfully determined that a copolymerization polymer molecule could be designed according to the catechol structural features and that high‐performance biomimetic mussel materials can be prepared from petrochemical materials or renewable materials, and because of their excellent performance in various application areas show a broad application prospect. The adhesion mechanism of the mussel protein and the recent advances in biomimetic mussel protein polymers based on nonphytogenic catechol derivatives and phytogenic catechol derivatives from different sources are comprehensively summarized. By comparing the application of nonphytogenic catechol derivatives and phytogenic catechol derivatives in industrial and biomedical fields, we found that the synthesis of phytogenic catechol derivatives is more facile and universal, and their application performance is as good as that of nonphytogenic catechol derivatives. In addition, the challenges and prospects for this field in the future are also discussed. © 2021 Society of Industrial Chemistry.

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Mussel-inspired bioadhesives in healthcare: design parameters, current trends, and future perspectives

Abstract: Mussel-inspired bioadhesives gain increasing interests in healthcare applications. In this review, adhesive mechanism, mussel-inspired bioadhesive synthesis and applications in healthcare are summarized and discussed.

Cited by 94 publications

References 101 publications

From vesicles to materials: bioinspired strategies for fabricating hierarchically structured soft matter

From vesicles to materials: bioinspired strategies for fabricating hierarchically structured soft matter

Biocompatible Catechol‐Functionalized Cellulose‐Based Adhesives with Strong Water Resistance

Mussel‐inspired polymer materials derived from nonphytogenic and phytogenic catechol derivatives and their applications

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