Mussel-inspired antimicrobial gelatin/chitosan tissue adhesive rapidly activated in situ by H2O2/ascorbic acid for infected wound closure

He, Xin; Sun, Ao; Li, Tao; Qian, Yong; Qian, Hong; Ling, Yun Fei; Zhang, Ling Hong; Liu, Qing Ya; Peng, Tao; Qian, Zhiyong

doi:10.1016/j.carbpol.2020.116692

Cited by 43 publications

(16 citation statements)

References 96 publications

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“…Dopamine (DA), as a material with excellent photothermal conversion and adhesion abilities, has attracted increasing attention. DA can be grafted onto polymer materials, such as GelMA [ 81 ], hyaluronic acid(HA) [ 82 ], and bioactive glass nanoparticles (BGNs) [ 83 ], to improve its adhesion ability. In addition, DA could chelate with other photothermal materials (such as Cu 2+ [ 84 ], and Ti [ 85 ]) to increase the photothermal performance of hydrogels.…”

Section: Composition Of Hydrogels With Photothermal Effectsmentioning

confidence: 99%

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Zhang

Tan

et al. 2021

Polymers

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Photothermal treatment (PTT) is a promising strategy to deal with multidrug-resistant bacteria infection and promote tissue regeneration. Previous studies demonstrated that hyperthermia can effectively inhibit the growth of bacteria, whereas mild heat can promote cell proliferation, further accelerating wound healing and bone regeneration. Especially, hydrogels with photothermal properties could achieve remotely controlled drug release. In this review, we introduce a photothermal agent hybrid in hydrogels for a photothermal effect. We also summarize the potential mechanisms of photothermal hydrogels regarding antibacterial action, angiogenesis, and osteogenesis. Furthermore, recent developments in photothermal hydrogels in wound healing and bone regeneration applications are introduced. Finally, future application of photothermal hydrogels is discussed. Hydrogels with photothermal effects provide a new direction for wound healing and bone regeneration, and this review will give a reference for the tissue engineering.

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Section: Composition Of Hydrogels With Photothermal Effectsmentioning

confidence: 99%

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Zhang

Tan

et al. 2021

Polymers

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“…The results showed that the Mg 2+ loaded hydrogel promoted osteogenesis and angiogenesis in both in vitro and in vivo models. Methacrylated-chitosan and GelMA were further modified with protocatechuic acid and dopamine to make an adhesive wound-closure biomaterial, where H2O2 and ascorbic acid could polymerize the gel within seconds [40]. In Figure 4b, bacteria-infected wounds in animal models showed complete wound closure at day 21 after the chitosan-GelMA treatment, while the small gap at the wound remained visible with the conventional suture treatment.…”

Section: Chitosanmentioning

confidence: 99%

Gelatin Methacrylate Hydrogel for Tissue Engineering Applications—A Review on Material Modifications

et al. 2022

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To recreate or substitute tissue in vivo is a complicated endeavor that requires biomaterials that can mimic the natural tissue environment. Gelatin methacrylate (GelMA) is created through covalent bonding of naturally derived polymer gelatin and methacrylic groups. Due to its biocompatibility, GelMA receives a lot of attention in the tissue engineering research field. Additionally, GelMA has versatile physical properties that allow a broad range of modifications to enhance the interaction between the material and the cells. In this review, we look at recent modifications of GelMA with naturally derived polymers, nanomaterials, and growth factors, focusing on recent developments for vascular tissue engineering and wound healing applications. Compared to polymers and nanoparticles, the modifications that embed growth factors show better mechanical properties and better cell migration, stimulating vascular development and a structure comparable to the natural-extracellular matrix.

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“…Therefore, the gelatin-based adhesive hydrogel provided a new method for wound closure and healing. He et al [64] prepared a mussel-inspired injectable hydrogel (catechol-and methacrylatemodified CS/gelatin (TCCG) using catechol and methacrylatemodified gelatin, which showed excellent biocompatibility and good adhesion to wet tissues. In order to test the effectiveness of the TCCG hydrogel as an anti-infective tissue glue, the back incisions of SD rats infected with S. aureus were treated with a blank TCCG hydrogel, cyanoacrylate and sutures.…”

Section: Alginate-based Tissue Adhesivementioning

confidence: 99%

Biodegradable polymer hydrogel‐based tissue adhesives: A review

Zhang

Jiang

Han

et al. 2021

Biosurface and Biotribology

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Tissue-adhesive materials are emerging biomaterials with potential applications in wound healing patches, tissue sealants, and haemostat materials. Tissue adhesives based on synthetic polymers generally have good adhesion but are not biodegradable. However, the long-term presence of non-biodegradable adhesives in the body can cause secondary harm to the patient. An ideal tissue adhesive should meet the following requirements: good adhesiveness, biodegradability, low cytotoxicity, and minimal inflammatory response. Natural polymers with inherent biodegradation and biocompatibility show great potentials in biomedical engineering, and the development of tissue adhesives based on natural polymers has become a hot topic in biomaterials science. This review systematically summarises the latest progresses in biodegradable tissue adhesives based on natural polymers, such as chitosan, hyaluronic acid, alginate, gelatin, dextran, and cellulose. Methods for preparing natural polymer tissue adhesives are summarised and their advantages and disadvantages are discussed. Finally, potential trends in the future direction of biodegradable tissue adhesives are discussed.

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Mussel-inspired antimicrobial gelatin/chitosan tissue adhesive rapidly activated in situ by H2O2/ascorbic acid for infected wound closure

Cited by 43 publications

References 96 publications

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Gelatin Methacrylate Hydrogel for Tissue Engineering Applications—A Review on Material Modifications

Biodegradable polymer hydrogel‐based tissue adhesives: A review

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