Mussel-inspired “all-in-one” sodium alginate/carboxymethyl chitosan hydrogel patch promotes healing of infected wound

Ouyang, Yongliang; Su, Xiaoju; Zheng, Xiaoyi; Zhang, Liang; Chen, Zheng; Yan, Qiling; Qian, Qinyuan; Zhao, Jiulong; Li, Ping; Wang, Shige

doi:10.1016/j.ijbiomac.2024.129828

Cited by 20 publications

(10 citation statements)

References 34 publications

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“…Chitosan hydrogels are bacteriostatic, compression-resistant, have good adhesion, and can be easily chemically modified. Through modification, this material can significantly improve the binding capacity and delivery efficiency to genes, thus promoting tissue wound healing more effectively [ 41 ]. Cai et al [ 15 ] used MMP-2 to modify carboxymethyl chitosan (CMCS-AGE) and prepared a hydrogel by loading siRNA complexes that target transforming growth factor-β1 (TGF-β1).…”

Section: Hydrogelsmentioning

confidence: 99%

Developing hydrogels for gene therapy and tissue engineering

Su,

Lin,

Huang

et al. 2024

J Nanobiotechnol

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Hydrogels are a class of highly absorbent and easily modified polymer materials suitable for use as slow-release carriers for drugs. Gene therapy is highly specific and can overcome the limitations of traditional tissue engineering techniques and has significant advantages in tissue repair. However, therapeutic genes are often affected by cellular barriers and enzyme sensitivity, and carrier loading of therapeutic genes is essential. Therapeutic gene hydrogels can well overcome these difficulties. Moreover, gene-therapeutic hydrogels have made considerable progress. This review summarizes the recent research on carrier gene hydrogels for the treatment of tissue damage through a summary of the most current research frontiers. We initially introduce the classification of hydrogels and their cross-linking methods, followed by a detailed overview of the types and modifications of therapeutic genes, a detailed discussion on the loading of therapeutic genes in hydrogels and their characterization features, a summary of the design of hydrogels for therapeutic gene release, and an overview of their applications in tissue engineering. Finally, we provide comments and look forward to the shortcomings and future directions of hydrogels for gene therapy. We hope that this article will provide researchers in related fields with more comprehensive and systematic strategies for tissue engineering repair and further promote the development of the field of hydrogels for gene therapy. Graphical abstract

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Section: Hydrogelsmentioning

confidence: 99%

Developing hydrogels for gene therapy and tissue engineering

Su,

Lin,

Huang

et al. 2024

J Nanobiotechnol

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“…It not only offers suitable physical support and biocompatibility but also guides cell proliferation to form specific tissues ( Suo et al, 2023 ). Presently, researchers have started blending sodium alginate with other high molecular weight materials to facilitate cell growth ( Ouyang et al, 2024 ). This blending technique offers a novel approach to develop biomedical materials with outstanding performance and is anticipated to be pivotal in the realm of tissue engineering.…”

Section: Classification Of Polymer-based Hydrogelsmentioning

confidence: 99%

Emerging roles of hydrogel in promoting periodontal tissue regeneration and repairing bone defect

Guo,

Dong,

Wang

2024

Front. Bioeng. Biotechnol.

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Periodontal disease is the most common type of oral disease. Periodontal bone defect is the clinical outcome of advanced periodontal disease, which seriously affects the quality of life of patients. Promoting periodontal tissue regeneration and repairing periodontal bone defects is the ultimate treatment goal for periodontal disease, but the means and methods are very limited. Hydrogels are a class of highly hydrophilic polymer networks, and their good biocompatibility has made them a popular research material in the field of oral medicine in recent years. This paper reviews the current mainstream types and characteristics of hydrogels, and summarizes the relevant basic research on hydrogels in promoting periodontal tissue regeneration and bone defect repair in recent years. The possible mechanisms of action and efficacy evaluation are discussed in depth, and the application prospects are also discussed.

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“…Although the application of CS in hemostasis has been reported, its lower hemostatic effect, compressive strength, and stability have hindered its further development due to its insolubility in water under physiological conditions. Mussel-inspired materials, based on catechols and polyphenols such as caffeic acid and gallic acid, have been widely used in biomedicine. − Compared with CS, polyphenol-modified CS has better hydrophilicity, which can absorb blood quickly; meanwhile, the phenolic hydroxyl groups contained in it can covalently bind with the proteins in the blood to form a barrier membrane to prevent bleeding. , However, this sponge is soft and does not have sufficient compressive strength to support the wound to achieve hemostasis for heavy bleeding. , In addition, some cross-linkers were usually employed to improve the mechanical properties of CS-based hemostatic dressing. However, these preparation technologies were very complex and the cross-linking agents may also cause cytotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Water-Triggered Self-Expanding Agarose/Chitosan-Gallate Hemostatic Sponge for Incompressible Wounds

Yang,

Zhao,

Liu

et al. 2024

ACS Appl. Polym. Mater.

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Incompressible deep wound bleeding is difficult to control and remains a formidable challenge. Here, a water-triggered self-expanding hemostatic sponge (AG/ GA-CS) was prepared using agarose (AG) and gallic acid-modified chitosan (GA-CS) via sequential physical mixing, freeze-drying, and a compression fixation process. The prepared AG/GA-CS sponge showed high mechanical performance and can expand rapidly after absorbing liquid, which can provide pressure on the wound to close it and ultimately form a physical hemostatic barrier to promote hemostasis. In addition, it showed good antioxidant performance and effectively inhibited bacterial proliferation. Moreover, the AG/GA-CS sponge can rapidly absorb blood and promote efficient aggregation and activation of negatively charged erythrocytes and platelets on its surface, further significantly improving the blood clotting efficiency. On this basis, in vivo, the hemostatic effect was investigated using three hemorrhage animal models, namely, the mouse liver puncture model, mouse femoral artery hemorrhage model, and rat liver defect model. Results suggested that the prepared AG/GA-CS sponge showed superior hemostatic effects compared with the commercial gelatin sponge. In particular, the total amount of bleeding was sharply reduced by about five times within 5 s in the rat liver defect model. Therefore, the prepared AG/GA-CS sponges showed potential applications in the hemostasis of incompressible wounds.

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Mussel-inspired “all-in-one” sodium alginate/carboxymethyl chitosan hydrogel patch promotes healing of infected wound

Cited by 20 publications

References 34 publications

Developing hydrogels for gene therapy and tissue engineering

Developing hydrogels for gene therapy and tissue engineering

Emerging roles of hydrogel in promoting periodontal tissue regeneration and repairing bone defect

Water-Triggered Self-Expanding Agarose/Chitosan-Gallate Hemostatic Sponge for Incompressible Wounds

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