Mussel-Inspired Adhesives and Coatings

Lee, Bruce P.; Messersmith, Phillip B.; Israelachvili, Jacob N.; Waite, J. Herbert

doi:10.1146/annurev-matsci-062910-100429

Cited by 1,488 publications

(1,586 citation statements)

References 112 publications

(148 reference statements)

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“…1e). [13][14][15] DOPA demonstrates high affinity for chemically distinct substrates via covalent or noncovalent interactions. Dopamine contains both side chain functionalities of DOPA and lysine, which resembles mussel adhesive proteins (Fig.…”

Section: Introductionmentioning

confidence: 99%

Fusion of nacre, mussel, and lotus leaf: bio-inspired graphene composite paper with multifunctional integration

et al. 2013

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Multifunctional integration is an inherent characteristic for biological materials with multiscale structures. Learning from nature is an effective approach for scientists and engineers to construct multifunctional materials. In nature, mollusks (abalone), mussels, and the lotus have evolved different and optimized solutions to survive. Here, bio-inspired multifunctional graphene composite paper was fabricated in situ through the fusion of the different biological solutions from nacre (brick-and-mortar structure), mussel adhesive protein (adhesive property and reducing character), and the lotus leaf (self-cleaning effect). Owing to the special properties (self-polymerization, reduction, and adhesion), dopamine could be simultaneously used as a reducing agent for graphene oxide and as an adhesive, similar to the mortar in nacre, to crosslink the adjacent graphene. The resultant nacre-like graphene paper exhibited stable superhydrophobicity, self-cleaning, anticorrosion, and remarkable mechanical properties underwater. Multifunctional integration is an inherent characteristic for biological materials with multiscale structures.Learning from nature is an effective approach for scientists and engineers to construct multifunctional materials. In nature, mollusks (abalone), mussels, and the lotus have evolved different and optimized solutions to survive. Here, bio-inspired multifunctional graphene composite paper was fabricated in situ through the fusion of the different biological solutions from nacre (brick-and-mortar structure), mussel adhesive protein (adhesive property and reducing character), and the lotus leaf (self-cleaning effect).Owing to the special properties (self-polymerization, reduction, and adhesion), dopamine could be simultaneously used as a reducing agent for graphene oxide and as an adhesive, similar to the mortar in nacre, to crosslink the adjacent graphene. The resultant nacre-like graphene paper exhibited stable superhydrophobicity, self-cleaning, anti-corrosion, and remarkable mechanical properties underwater.

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Section: Introductionmentioning

confidence: 99%

Fusion of nacre, mussel, and lotus leaf: bio-inspired graphene composite paper with multifunctional integration

et al. 2013

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“…1 Mussel adhesive proteins are thus important molecular factors in marine fouling as well as useful paradigms of the robust, yet-to-beinvented underwater adhesive and coating polymers that are needed for wide-ranging medical and industrial applications. 2,3 At the end of each byssal, thread is an adhesive plaque where interfacial adhesion between the byssus and a foreign substratum occurs. The byssus is mainly made of various proteins secreted from a phenol gland of mussel feet and the proteins that comprise byssus are called mussel foot proteins (mfps).…”

Section: Introductionmentioning

confidence: 99%

“…To date, eight different types of mfps have been isolated and interestingly, most display extensive post-translational modifications of their primary sequences. 2 At present, attempts to mimic mussel-inspired adhesives and coatings have been conducted largely on the basis of primary sequence information 4,5 ; however, an understanding of biomechanical and structural properties of mfps is also prerequisite for mimicking mussel adhesion and coating to invent novel adhesives and coatings.…”

Section: Introductionmentioning

confidence: 99%

Three intrinsically unstructured mussel adhesive proteins, mfp‐1, mfp‐2, and mfp‐3: Analysis by circular dichroism

Hwang

Waite

2012

Protein Science

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Mussel foot proteins (mfps) mediate fouling by the byssal holdfast and have been extensively investigated as models for versatile polymer-mediated underwater adhesion and coatings. However, insights into the structural properties of mfps have lagged far behind the nanomechanical advances, owing in part to the inability of these proteins to crystallize as well as their limited solubility. Here, solution secondary structures of mfp-1, mfp-2, and mfp-3, localized in the mussel byssal cuticle, adhesive plaque, and plaque-substratum interface, respectively, were investigated using circular dichroism. All three have significant extended coil solution structure, but two, mfp-1 and mfp-2, appear to have punctuated regions of structure separated by unstructured domains. Apart from its punctuated distribution, the structure in mfp-1 resembles other structural proteins such as collagen and plant cell-wall proteins with prominent polyproline II helical structure. As in collagen, PP II structure of mfp-1 is incrementally disrupted by increasing the temperature and by raising pH. However, no recognizable change in mfp-1's PP II structure was evident with the addition with Ca 21 and Fe 31 . In contrast, mfp-2 exhibits Ca 21 -and disulfidestabilized epidermal growth factor-like domains separated by unstructured sequence. Mfp-2 showed calcium-binding ability. Bound calcium in mfp-2 was not removed by chelation at pH 5.5, but it was released upon reduction of disulfide bonds. Mfp-3, in contrast, appears to consist largely of unstructured extended coils.

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“…The strong interaction of L-3,4-dihydroxyphenyalanine (DOPA) to metal surfaces has been applied for the coating of different biomaterials (Lee et al, 2011a). This post-translationally modified amino acid was found to be the pivotal moiety in mussel adhesive proteins that can stick to a variety of surfaces under wet conditions (Waite, 1983).…”

Section: Introductionmentioning

confidence: 99%

Multifunctional biomaterial coatings: synthetic challenges and biological activity

Pagel

Beck‐Sickinger

2017

Biological Chemistry

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A controlled interaction of materials with their surrounding biological environment is of great interest in many fields. Multifunctional coatings aim to provide simultaneous modulation of several biological signals. They can consist of various combinations of bioactive, and bioinert components as well as of reporter molecules to improve cell-material contacts, prevent infections or to analyze biochemical events on the surface. However, specific immobilization and particular assembly of various active molecules are challenging. Herein, an overview of multifunctional coatings for biomaterials is given, focusing on synthetic strategies and the biological benefits by displaying several motifs.

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Mussel-Inspired Adhesives and Coatings

Cited by 1,488 publications

References 112 publications

Fusion of nacre, mussel, and lotus leaf: bio-inspired graphene composite paper with multifunctional integration

Fusion of nacre, mussel, and lotus leaf: bio-inspired graphene composite paper with multifunctional integration

Three intrinsically unstructured mussel adhesive proteins, mfp‐1, mfp‐2, and mfp‐3: Analysis by circular dichroism

Multifunctional biomaterial coatings: synthetic challenges and biological activity

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