Mussel adhesion-employed water-immiscible fluid bioadhesive for urinary fistula sealing

Kim, Hyo Jeong; Hwang, Byeong Hee; Lim, Seonghye; Choi, Bong Hyuk; Kang, Seok Ho; Joon, Hyung

doi:10.1016/j.biomaterials.2015.08.055

Cited by 87 publications

(71 citation statements)

References 39 publications

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“…6B). The E. coli inhibition ratios of 29 mg/mL of CA were all around 95%, lower than that against S. aureus , which is in agreement with our previous work [20]. The control sample, PEGDA/HEMA, also exhibited no inhibition against E. coli .…”

Section: Resultssupporting

confidence: 90%

“…The development of injectable citrate-based mussel-inspired bioadhesives (iCMBA) fully utilized the facile reactivity of citric acid to modify our citrate-based polymer with dopamine, a derivative of L-3, 4-dihydroxyphenylalanine (L-DOPA) that contributes to the strong under-water adhesive properties of marine mussels [19, 20], through a convenient one-pot polycondensation process [18]. Citric acid is a naturally-derived organic compound that abundantly exists in citrus fruits, such as lemons and limes.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and characterization of anti-bacterial and anti-fungal citrate-based mussel-inspired bioadhesives

Guo

Wang

et al. 2016

Biomaterials

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Bacterial and fungal infections in the use of surgical devices and medical implants remain a major concern. Traditional bioadhesives fail to incorporate anti-microbial properties, necessitating additional anti-microbial drug injection. Herein, by the introduction of the clinically used and inexpensive anti-fungal agent, 10-undecylenic acid (UA), into our recently developed injectable citrate-based mussel-inspired bioadhesives (iCMBAs), a new family of anti-bacterial and anti-fungal iCMBAs (AbAf iCs) was developed. AbAf iCs not only showed strong wet tissue adhesion strength, but also exhibited excellent in vitro cyto-compatibility, fast degradation, and strong initial and considerable long-term anti-bacterial and anti-fungal ability. For the first time, the biocompatibility and anti-microbial ability of sodium metaperiodate (PI), an oxidant used as a cross-linking initiator in the AbAf iCs system, was also thoroughly investigated. Our results suggest that the PI-based bioadhesives showed better anti-microbial properties compared to the unstable silver-based bioadhesive materials. In conclusion, AbAf iCs family can serve as excellent anti-bacterial and anti-fungal bioadhesive candidates for tissue/wound closure, wound dressing, and bone regeneration, especially when bacterial or fungal infections are a major concern.

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Section: Resultssupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of anti-bacterial and anti-fungal citrate-based mussel-inspired bioadhesives

Guo

Wang

et al. 2016

Biomaterials

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“…Furthermore, because coacervates do not disperse in aqueous solutions their “on-site” delivery, for instance for soft tissues adhesion, is more convenient. [36] Additionally, coacervates exhibit an extremely low interfacial energy, [13a] which results in easy wetting and spreading onto wet hydrated surfaces. The simultaneous presence of Dopa and of a coacervate phase in our synthetic peptide significantly enhances adhesion under wet conditions by displacing surface-bound water molecules – the nemesis of wet adhesion – thereby allowing intimate interaction with the substrate surface.…”

Section: Discussionmentioning

confidence: 99%

An Underwater Surface‐Drying Peptide Inspired by a Mussel Adhesive Protein

Wei

Petrone

Tan

et al. 2016

Adv Funct Materials

176

168

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Water hampers the formation of strong and durable bonds between adhesive polymers and solid surfaces, in turn hindering the development of adhesives for biomedical and marine applications. Inspired by mussel adhesion, a mussel foot protein homologue (mfp3S-pep) is designed, whose primary sequence is designed to mimic the pI, polyampholyte, and hydrophobic characteristics of the native protein. Noticeably, native protein and synthetic peptide exhibit similar abilities to self-coacervate at given pH and ionic strength. 3,4-dihydroxy-l-phenylalanine (Dopa) proves necessary for irreversible peptide adsorption to both TiO2 (anatase) and hydroxyapatite (HAP) surfaces, as confirmed by quartz crystal microbalance measurements, with the coacervate showing superior adsorption. The adsorption of Dopa-containing peptides is investigated by attenuated total reflection infrared spectroscopy, revealing initially bidentate coordinative bonds on TiO2, followed by H-bonded and eventually long-ranged electrostatic and Van der Waals interactions. On HAP, mfp3s-pep-3Dopa adsorption occurs predominantly via H-bond and outer-sphere complexes of the catechol groups. Importantly, only the Dopa-bearing compounds are able to remove interfacial water from the target surfaces, with the coacervate achieving the highest water displacement arising from its superior wetting properties. These findings provide an impetus for developing coacervated Dopa-functionalized peptides/polymers adhesive formulations for a variety of applications on wet polar surfaces.

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“…The main biomedical areas for such adhesives include bone, cartilage, and tissue repair, as well as implants . For example, coacervate‐based adhesives composed of poly(acrylamide‐ co ‐aminopropyl methacrylamide)‐poly(ethylene glycol diacrylate) and poly(2‐(methacryloyloxy)ethyl phosphate dopamine methacrylamide)‐poly(ethylene glycol diacrylate) were used in vitro to seal an iatrogenic defect in a fetal membrane patch.…”

Section: Applicationsmentioning

confidence: 99%

Complex coacervate‐based materials for biomedicine

Blocher

Perry

2016

WIREs Nanomed Nanobiotechnol

223

277

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There has been increasing interest in complex coacervates for deriving and transporting biomaterials. Complex coacervates are a dense, polyelectrolyte-rich liquid that results from the electrostatic complexation of oppositely-charged macro-ions. Coacervates have long been used as a strategy for encapsulation, particularly in food and personal care products. More recent efforts have focused on the utility of this class of materials for the encapsulation of small molecules, proteins, RNA, DNA, and other biomaterials for applications ranging from sensing to biomedicine. Furthermore, coacervate-related materials have found utility as in other areas of biomedicine, including cartilage mimics, tissue culture scaffolds, and adhesives for wet, biological environments. Here, we discuss the self-assembly of complex coacervate-based materials, current challenges in the intelligent design of these materials, and their utility applications in the broad field of biomedicine.

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Mussel adhesion-employed water-immiscible fluid bioadhesive for urinary fistula sealing

Cited by 87 publications

References 39 publications

Synthesis and characterization of anti-bacterial and anti-fungal citrate-based mussel-inspired bioadhesives

Synthesis and characterization of anti-bacterial and anti-fungal citrate-based mussel-inspired bioadhesives

An Underwater Surface‐Drying Peptide Inspired by a Mussel Adhesive Protein

Complex coacervate‐based materials for biomedicine

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