Muskelin acts as a substrate receptor of the highly regulatedDrosophilaCTLH E3 ligase during the maternal-to-zygotic transition
Chloe A. Briney,
Jesslyn C. Henriksen,
Chenwei Lin
et al.
Abstract:The maternal-to-zygotic transition (MZT) is a conserved developmental process where the maternally-derived protein and mRNA cache is replaced with newly made zygotic gene products. We have previously shown that inDrosophilathe deposited RNA-binding proteins ME31B, Cup, and Trailer Hitch (TRAL) are ubiquitylated by the CTLH E3 ligase and cleared. However, the organization and regulation of the CTLH complex remain poorly understood in flies. In particular,Drosophilalacks an identifiable substrate adaptor, and th… Show more
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