Music therapy as a non-pharmacological treatment for epilepsy

Liao, Huan; Jiang, Guohui; Wang, Xuefeng

doi:10.1586/14737175.2015.1071191

Cited by 13 publications

(12 citation statements)

References 89 publications

(102 reference statements)

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“…The exact neural mechanisms underlying reducing seizures by listening to music have not been determined yet. The potential theories on the effect of listening to music on central nervous system have been discussed in detail in a number of the previous review work 6,20,36 . A number of studies additionally have suggested a potential mechanism involving activation of different cortical areas while listening to music 4,14,27,37 .…”

Section: Discussionmentioning

confidence: 99%

Daily listening to Mozart reduces seizures in individuals with epilepsy: A randomized control study

et al. 2020

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Objective: Epilepsy is one of the most common neurological disorders . Many individuals continue to have seizures despite medical and surgical treatments, suggesting adjunctive management strategies are required. Promising effects of daily listening to Mozart on reducing seizure frequency in individuals with epilepsy have been demonstrated over the last 20 years, but not in a rigorously controlled manner.In this study, we compared the effect on seizure frequency of daily listening to either Mozart K.448 or a spectrally similar, yet non-rhythmic control piece. We hypothesized that there would be no difference in seizure counts when participants listened to Mozart K.448 vs when they listened to the control piece. Methods: We employed a randomized crossover design, in which each participant was exposed to both three months of daily listening to the first six minutes of Sonata for two pianos in D major by Mozart (Mozart K.448; treatment period) and three months of daily listening to phase-scrambled version (control period). There was a three-month baseline and a three-month follow-up period before and after the sixmonth listening period, respectively. Change in seizure counts obtained from the seizure diaries was considered as the main study outcome. Results: Using three methodologies to investigate the existence of the treatment effect (paired t test, estimation statistics and plots, and Cohen's d), our results revealed a reduction in seizure counts during the treatment period, which was not observed for the control period (P-value < .001). Significance: Using a spectrally similar control piece, our study advances previous reports that were limited by a "no music" control condition. Daily listening to Mozart K.448 was associated with reducing seizure frequency in adult individuals with epilepsy. These results suggest that daily Mozart listening may be considered as an adjunctive therapeutic option to reduce seizure burden in individuals with epilepsy. |

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Section: Discussionmentioning

confidence: 99%

Daily listening to Mozart reduces seizures in individuals with epilepsy: A randomized control study

et al. 2020

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“…Music therapy recognized as an alternative non-invasive and non-pharmacological therapy for treating epilepsy. The efficacy of music in controlling seizures was first reported by Fernandez et al, by observing in an experiment that a frequency of 1000 Hz is effective in reducing the seizures interval by using the EEG recordings ( Liao et al, 2015 ). Besides that, different studies have reported that listening to Mozart music can affect individual intellectual abilities, which is well-known as the “Mozart effect”.…”

Section: Complementary Therapiesmentioning

confidence: 99%

“…in juvenile and frontal lobe epilepsy. It had been studied that listening to music enhances the dopaminergic activity in basal ganglia i.e., upregulation of its D2 receptors and also stimulation of the release of dopamine ( Liao et al, 2015 , Maguire, 2012 ) Mirror neurons: Different authors have suggested the involvement of mirror neurons in the antiepileptic effect of music. Mirror neurons are discharged when a person performs any motor action like dancing etc.…”

Section: Complementary Therapiesmentioning

confidence: 99%

Non-pharmacological Interventions for Intractable Epilepsy

Alqahtani

Imran

Pervaiz

et al. 2020

Saudi Pharmaceutical Journal

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In 30% of epileptic individuals, intractable epilepsy represents a problem for the management of seizures and severely affects the patient's quality of life due to pharmacoresistance with commonly used antiseizure drugs (ASDs). Surgery is not the best option for all resistant patients due to its post-surgical consequences. Therefore, several alternative or complementary therapies have scientifically proven significant therapeutic potential for the management of seizures in intractable epilepsy patients with seizure-free occurrences. Various non-pharmacological interventions include metabolic therapy, brain stimulation therapy, and complementary therapy. Metabolic therapy works out by altering the energy metabolites and include the ketogenic diets (KD) (that is restricted in carbohydrates and mimics the metabolic state of the body as produced during fasting and exerts its antiepileptic effect) and anaplerotic diet (which revives the level of TCA cycle intermediates and this is responsible for its effect). Neuromodulation therapy includes vagus nerve stimulation (VNS), responsive neurostimulation therapy (RNS) and transcranial magnetic stimulation therapy (TMS). Complementary therapies such as biofeedback and music therapy have demonstrated promising results in pharmacoresistant epilepsies. The current emphasis of the review article is to explore the different integrated mechanisms of various treatments for adequate seizure control, and their limitations, and supportive pieces of evidence that show the efficacy and tolerability of these non-pharmacological options.

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“…Music showed clinical benefits of reducing acute and chronic pain (25)(26)(27). For epilepsy, there is clinical and preclinical evidence that specific musical compositions exert anticonvulsant effects (4,(28)(29)(30)(31)(32). Clinical studies showed that exposure to Mozart's K.448 sonata in pediatric epilepsy patients, even those with refractory seizures, caused a significant reduction of seizure frequency and epileptiform discharges (33)(34)(35)(36)(37)(38)(39).…”

Section: Introductionmentioning

confidence: 99%

Music-Enhanced Analgesia and Antiseizure Activities in Animal Models of Pain and Epilepsy: Toward Preclinical Studies Supporting Development of Digital Therapeutics and Their Combinations With Pharmaceutical Drugs

Metcalf

Huntsman

Garcia³

et al. 2019

Front. Neurol.

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Digital therapeutics (software as a medical device) and mobile health (mHealth) technologies offer a means to deliver behavioral, psychosocial, disease self-management and music-based interventions to improve therapy outcomes for chronic diseases, including pain and epilepsy. To explore new translational opportunities in developing digital therapeutics for neurological disorders, and their integration with pharmacotherapies, we examined analgesic and antiseizure effects of specific musical compositions in mouse models of pain and epilepsy. The music playlist was created based on the modular progression of Mozart compositions for which reduction of seizures and epileptiform discharges were previously reported in people with epilepsy. Our results indicated that music-treated mice exhibited significant analgesia and reduction of paw edema in the carrageenan model of inflammatory pain. Among analgesic drugs tested (ibuprofen, cannabidiol (CBD), levetiracetam, and the galanin analog NAX 5055), music intervention significantly decreased paw withdrawal latency difference in ibuprofen-treated mice and reduced paw edema in combination with CBD or NAX 5055. To the best of our knowledge, this is the first animal study on music-enhanced antinociceptive activity of analgesic drugs. In the plantar incision model of surgical pain, music-pretreated mice had significant reduction of mechanical allodynia. In the corneal kindling model of epilepsy, the cumulative seizure burden following kindling acquisition was lower in animals exposed to music. The music-treated group also exhibited significantly improved survival, warranting further research on music interventions for preventing Sudden Unexpected Death in Epilepsy (SUDEP). We propose a working Metcalf et al. Music-Enhanced Analgesic and Antiseizure Activities model of how musical elements such as rhythm, sequences, phrases and punctuation found in K.448 and K.545 may exert responses via parasympathetic nervous system and the hypothalamic-pituitary-adrenal (HPA) axis. Based on our findings, we discuss: (1) how enriched environment (EE) can serve as a preclinical surrogate for testing combinations of non-pharmacological modalities and drugs for the treatment of pain and other chronic diseases, and (2) a new paradigm for preclinical and clinical development of therapies leading to drug-device combination products for neurological disorders, depression and cancer. In summary, our present results encourage translational research on integrating non-pharmacological and pharmacological interventions for pain and epilepsy using digital therapeutics.

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Music therapy as a non-pharmacological treatment for epilepsy

Cited by 13 publications

References 89 publications

Daily listening to Mozart reduces seizures in individuals with epilepsy: A randomized control study

Daily listening to Mozart reduces seizures in individuals with epilepsy: A randomized control study

Non-pharmacological Interventions for Intractable Epilepsy

Music-Enhanced Analgesia and Antiseizure Activities in Animal Models of Pain and Epilepsy: Toward Preclinical Studies Supporting Development of Digital Therapeutics and Their Combinations With Pharmaceutical Drugs

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